Vergangene Seminare seit 2016

The type VI secretion systems of Pseudomonas aeruginosa

Microbiology Seminar Series

RNA Biochemistry

Workshop

Future Network Talks #18

Career Development and Networking Session

Scientific writing: Turning the blank page into a manuscript

Workshop

Graduate Students Mini Symposium III-2024

Graduate Students Mini-Symposium

Workshop: Job Searching Strategy 2023 & Unlock the Full Potential of Your Resume

Workshop

Genetic circuits on single DNA molecules, with and without cell-like compartments

Microbiology Seminar Series

Future Network Talks #17

Career Development and Networking Session

Graduate Students Mini Symposium II-2024

Graduate Students Mini-Symposium

Synthetic membranes, synthetic cells: Exploring the new frontier of cell engineering with polymers

Microbiology Seminar Series

Graduate Students Mini Symposium I-2024

Graduate Students Mini-Symposium

Future Network Talks #16

Career Development and Networking Session

Evolution of essential complexity in Rubisco

Doctoral thesis defense

Graduate Students Mini Symposium XI-2023

Graduate Students Mini-Symposium

Future Network Talks #15

Career Development and Networking Session

Genetic and non-genetic solutions to survive a lethal metabolic stress in Methylobacterium extorquens

Microbiology Seminar Series

Why is E. coli's brain tuned so close to criticality?

Microbiology Seminar Series

Future Network Talks #14

Career Development and Networking Session

Graduate Students Mini Symposium X-2023

Graduate Students Mini-Symposium

Graduate Students Mini Symposium IX-2023

Graduate Students Mini-Symposium

Engineering yeast for methanol-based biomanufacturing

Methanol is an ideal feedstock for bio-manufacturing that can be beneficial for global carbon neutrality. However, the toxicity of methanol limits the efficiency of methanol metabolism toward biochemical production, and it is still challenging in engineering this non-conventional yeast due to serious lack of genetic editing tools. In this presentation, we will show our recent progress in establishing CRISPR-Cas9 based genome editing tools and enhancing the homologous recombination in methylotrophic yeast Ogataea polymorpha. With this genetic platform, we tried to engineer cellular metabolism for fatty acid production from methanol. We found that engineering overproduction of free fatty acids (FFA) from sole methanol resulted cell death with a decreased cellular phospholipid in O. polymorpha, and the cell growth was restored by adaptive laboratory evolution (ALE). Whole genome sequencing of the adapted strains reveals that inactivation of LPL1 (encoding a putative lipase) and IZH3 (encoding a membrane protein related to zinc metabolism) preserve cell survival by restoring phospholipid metabolism. Engineering the pentose phosphate pathway and gluconeogenesis enabled high-level production of FFA (15.9 g/L) from sole methanol. Preventing methanol-associated toxicity underscored the link between lipid metabolism and methanol tolerance, which should contribute to enhancing methanol-based bio-manufacturing. [mehr]

The evolution of the molecular toolkit for pluripotent stem cells

We use native and re-designed versions of SOX and OCT transcription factors to reprogram somatic cells into induced pluripotent stem cells and for stem cell engineering. In mammals, what distinguishes paralogous SOX factors is their ability to dimerize with OCT4 on distinctive composite DNA elements to induce stemness (SOX2) or specify the germline (SOX17). The selective partnership of these two SOX factors with OCT4 is primarily directed by a single amino acid conserved across animals. Mutating this amino acid converts SOX17 into an enhanced 'super SOX2', termed eSOX17, which speeds up pluripotency induction. In human cells, eSOX17 enables the direct conversion of somatic cells into totipotent cells. In two-factor cocktails, eSOX17 can transdifferentiate human blood into induced brain stem cells, avoiding the rejuvenation associated with pluripotency induction. Inspired by the close partnership between SOX/OCT and the potential of re-engineered variants for cellular reprogramming, we have begun to study their evolutionary history. Until now, SOX and OCT factors have been believed to be unique to animals. Surprisingly, we identified these factors in certain lineages of unicellular holozoans and found that they can replace SOX2 to induce pluripotency in mice. It is possible that the emergence of the molecular toolkit essential for mammalian pluripotency predates the evolution of multicellularity. [mehr]

Graduate Students Mini Symposium VIII - 2023

Graduate Students Mini-Symposium

Evolution of evolvability: adaptive hyper mutability by lineage selection

Microbiology Seminar Series
The bacterial flagellar motor is a membrane-embedded rotary macromolecular machine that converts the electrochemical energy of the proton gradient into the mechanical energy of rotation. The knowledge about the bacterial motor is a source of inspiration for nanotechnology and one of the first steps towards making artificial motors on the same scale. Recent breakthrough electron cryotomography studies have revealed proteinaceous periplasmic structures adjacent to the stator (the powerhouse) of polar flagellar motors, which are essential for the stator assembly and function. The talk will showcase the cutting-edge research on the structure, composition, and function of the periplasmic scaffold in the polar bacterial flagellar motor of Helicobacter pylori. This microorganism displays high motility in the very viscous mucous layer of the stomach, which enables us to use H. pylori as a model system to study the polar motor specialised for locomotion in highly viscous fluids. The presented work will illustrate the advantages of an interdisciplinary approach combining biology and physics. The presentation will conclude with the discussion of the new paradigm for how the previously unseen accessory components control the function of the flagellar motor. [mehr]

Game of Tug-of-war: ParA2 oscillations spatially regulates Vibrio cholerae chromosome 2 segregation

Microbiology Seminar Series

Graduate Students Mini Symposium VII - 2023

Graduate Students Mini-Symposium

Nitrogen fixation in cyanobacteria: Mechanism for coexist of oxygen-sensitive enzymes and oxygenic photosynthesis

Guest Speaker Talk

Towards the extension of the substrate spectrum of the [Fe]-hydrogenase Hmd

Doctoral thesis defense

Hydride intermediates in the catalytic turnover of gas-processing metalloenzymes from diverse microorganisms

Microbiology Seminar Series

Graduate Students Mini Symposium VI - 2023

Graduate Students Mini-Symposium

A metabolic portrait of the developing bacterial endospore

Microbiology Seminar Series

Characterization of Type IV-A CRISPR-Cas systems

Doctoral thesis defense

More is Different: Membrane Protein Function as a Collective Phenomenon

Microbiology Seminar Series

Graduate Students Mini Symposium V - 2023

Graduate Students Mini-Symposium

Non-canonical molecular biology of bacteriophages

Microbiology Seminar Series

Roots and bacteria: Basis of attraction

Microbiology Seminar Series

Evolution of evolvability: adaptive hyper mutability by lineage selection

Microbiology Seminar Series

Design and directed evolution of artificial lanthanide enzymes

Microbiology Seminar Series

Graduate Students Mini Symposium IV-2023

Graduate Students Mini-Symposium

Structure and function of non-cysteinyl coordinated Fe/S proteins

Microbiology Seminar Series

Investigating the kinetochore complex in Schizosaccharomyces pombe using advanced fluorescence microscopy techniques

Doctoral thesis defense

Protein transport in bacteria: multiple pathways and common concepts

Microbiology Seminar Series

Enzymatic systems for synthetic formate assimilation

Doctoral thesis defense

Graduate Students Mini Symposium III-2023

Graduate Students Mini-Symposium

Graduate Students Mini Symposium II 2023

Microbiology Seminar Series

Graduate Students Mini Symposium I 2023

Microbiology Seminar Series

Graduate Students Mini Symposium VIII

Microbiology Seminar Series

Decoupling of growth and overproduction of chemicals in Escherichia coli

Doctoral thesis defense

Protein diffusion in the cytoplasm of Escherichia coli

Doctoral thesis defense

b-NAD as a Building Block in Natural Product Biosynthesis

Microbiology Seminar Series

Graduate Students Mini-Symposium VII 2022

Graduate Students Mini-Symposium

The diverse functions and mechanisms of prokaryotic Argonaute proteins

Microbiology Seminar Series

Coevolution in the termite-protist symbiosis

Microbiology Seminar Series

Diversity, function and oxygen relationship of free-living and flagellate-associated Opitutales (phylum Verrucomicrobiota) in termite gut

PhD Defense

Graduate Students Mini-Symposium VI 2022

Graduate Students Mini-Symposium

Partners in slime: How mucus regulates microbial virulence

Microbiology Seminar Series

Graduate Students Mini-Symposium V 2022

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium IV 2022

Graduate Students Mini-Symposium

Microbial determinants of folivory in beetles

Microbiology Seminar Series

Graduate Students Mini-Symposium III 2022

Graduate Students Mini-Symposium

How to catch a nematode if you were a mushroom

Microbiology Seminar Series

The predation strategy of Myxococcus xanthus

Microbiology Seminar Series

Graduate Students Mini-Symposium II 2022

Graduate Students Mini-Symposium

Graduate Students Mini Symposium I 2022

Graduate Students Mini-Symposium

Integrative analysis and genome engineering of the near-minimal bacterium Mesoplasma florum

Microbiology Seminar Series

Graduate Students Mini-Symposium VII 2021

Transmission modes in two-component systems

Microbiology Seminar Series

Graduate Students Mini Symposium VI 2021

Phylogenomics and the early evolution of Bacteria

Microbiology Seminar Series

Graduate Students Mini Symposium V 2021

High-Andean Microbial Ecosystems: From Lakes to photoreceptors

Microbiology Seminar Series

A 50-years old mechanistic mystery resolved - an exploration of the enzyme reaction mechanism of 3-ketosteroid delta1-dehydrogenase by experimental and theoretical techniques

Microbiology Seminar Series

Bacterial Danger-Sensing Protects Against Bacteriophage Predation

PhD Defense

Mechanisms for chromosome folding and segregation in Bacillus subtilis

SFB/Transregio TRR 174

Small but effective! Newly identified players in nitrogen regulation in Methanosarcina mazei

Microbiology Seminar Series

Graduate Students Mini Symposium IV 2021

A biophysical approach to RNA transcription

Microbiology Seminar Series

The proton motive force determines Escherichia coli’s robustness to extracellular pH

Microbiology Seminar Series

Molecular function and regulation of the bacterial injectisome

PhD Defense

Graduate Students Mini Symposium III 2021

Income tax seminar for international scholars

Special seminar

Cell-free systems for on-demand biomanufacturing, molecular sensing, and education

Microbiology Seminar Series

Evolution of high torque flagellar motors and coevolution of cell plan in the Campylobacterota

Microbiology Seminar Series

At the crossroads of bacterial signaling and RNA degradation

Microbiology Seminar Series

IMPRS Selection Symposium

Feeling the pinch: New insights into regulation of the E. coli divisome

SFB/Transregio TRR 174

Graduate Students Mini Symposium II 2021

Introduction of the Max Planck Research Group: Bacterial Epitranscriptomics

Microbiology Seminar Series

How to kill your rivals: microbial warfare mediated by the Type VI secretion system of Serratia marcescens

Microbiology Seminar Series

Deregulation of the Clp protease by ADEP antibiotics - recent news

SFB/Transregio TRR 174

Image Segmentation of Bacterial Cells in Biofilms

PhD Defense

Fitness effects of horizontal gene transfer

Microbiology Seminar Series

Dynamics, Feedback, and Transient Antibiotic Resistance in Single Cells

Microbiology Seminar Series

Graduate Students Mini Symposium I 2021

Structural Proteomics of the Fungal Cell Wall

PhD Defense

Teaching an old dog new trick - engineering E. coli for new-to-nature metabolism

Microbiology Seminar Series

Biochemical Characterization of the Phoslactomycin modular Polyketidesynthase

PhD Defense

How FtsZ forms a ring - the emergence of large-scale order from local interactions between treadmilling filaments

SFB/Transregio TRR 174

Graduate Students Mini Symposium VIII 2020

Expanding the repertoire of enzymatic C‑C bond formation with one-carbon units

PhD Defense

Synthetic bacterial communities to probe microbial community functions

Microbiology Seminar Series

Determinants of bacterial cell shape and size

SFB/Transregio TRR 174

Graduate Students Mini Symposium VII 2020

tba

SFB/Transregio TRR 174

Establishment and maintenance of cell polarity in Myxococcus xanthus

PhD Defense

Tapping cyanobacteria for sugar: increasing photosynthetic potential and engineering solar-driven microbial consortia for bioproduction

Microbiology Seminar Series

From stress to success: how actinobacteria exploit life without a cell wall

SFB/Transregio TRR 174

Implementation of CO2 fixation pathways into Methylorubrum extorquens AM1

PhD Defense

Realization of a New-to-Nature Carboxylation Pathway

PhD Defense

Fighting the spread of antibiotic resistance with bacterial competence inhibitors

SFB/Transregio TRR 174

Division of labour and disease dynamics in clonal ant societies

Microbiology Seminar Series

Microbial Symbioses and the Evolution of Novel Organelles

Microbiology Seminar Series

The dynamic machinery of bacterial riboregulation (and some potential application for SARS COV2)

SFB/Transregio TRR 174

A purely Lamarckian ‘evolution’ permits survival of a bacterium to a lethal stressor

Microbiology Seminar Series

Coming in for a landing: bacterial signaling pathways activated upon surface contact

SFB/Transregio TRR 174

Implant Infection and Innate Immunity

Microbiology Seminar Series

Why was a complement inhibitor used in the 2011 German EHEC outbreak?

SFB/Transregio TRR 174

The coming of age of de novo protein design

Microbiology Seminar Series

Engineering bioremediation agents: from the test tube to planet Earth

Microbiology Seminar Series

IMPRS Selection Symposium

From stress to success: how actinobacteria exploit life without a cell wall

SFB/Transregio TRR 174

From insects to plants - Phenotypic switching of insect pathogenic Photorhabdus luminescens bacteria

SFB 987 Mini-Symposium

New bacterial degradation pathways for natural, environmental and intestinal organosulfonates

SFB 987 Mini-Symposium

Learning from predatory bacteria: from `omics´ to molecular mechanisms

Microbiology Seminar Series

Coordination of cell wall homeostasis with cell division: Genes, suppressors and beyond

SFB/Transregio TRR 174

Gene transfer agent: Evolution, function, and role in bacterial adaptation

SFB 987 Mini-Symposium

Photosynthetic Life in Hot Acid - Genomic and Physiological Insights into Extremophily in the Cyanidiales

SFB 987 Mini-Symposium

Apoplastic effectors in maize - U.maydis interface

Microfluidic single-cell cultivation: Concept, application and challenges

Microbiology Seminar Series

Development of molecular tools for research on red and green algae

SFB 987 Mini-Symposium

Breaching the Barrier: Quantifying Antibiotic Permeability across Gram-negative Bacterial Membranes

SFB 987 Mini-Symposium

Kicking the"BolA" in Bacterial Survival and Virulence

SFB 987 Mini-Symposium

Mechanisms of microbiota-pathogen interactions

SFB 987 Mini-Symposium

The Role of Genomic Context in Bacterial Growth Homeostasis

PhD Defense

Salmonella-microbiome interactions in the gut and their impact on transmission

Microbiology Seminar Series

Pseudomonas aeruginosa transcription profiling

SFB 987 Mini-Symposium

The bacterial stringent response in the context of root nodule symbiosis

SFB 987 Mini-Symposium

Disulfide bond formation underpins antimicrobial resistance in Enterobacteria

Microbiology Seminar Series

Bacterial "gap junctions" in cell-cell communication of multicellular cyanobacteria

SFB/Transregio TRR 174

Faculty of 1000 at Max Planck Institutes

Special seminar

Visualizing Bacterial Physiology at High Resolution using Single-Molecule Tracking and Lattice-Light Sheet Microscopy

Transcriptional regulators in the archaeon Sulfolobus acidocaldarius: homologies and differences with bacterial regulators

Microbiology Seminar Series

Powering LPS transport across the bacterial cell envelope with ABCs

Transregio TRR 174 Seminar

STUDIES OF SINGLE-MOLECULE DYNAMICS IN MICROORGANISMS

PhD Defense

Graduate Students Mini-Symposium II/2019

Graduate Students Mini-Symposium

Molecular mechanism of sulfur mobilization toward Fe-S cluster biosynthesis

Special seminar

Managing the bacterial chromosome

Transregio TRR 174 Seminar

Dynamics of bacterial biofilm predation

PhD Defense

From biofuels to biotherapeutics - Engineering metalloenzymes for a better future

Microbiology Seminar Series

Protecting the offspring – Linking developmental pathways of Aspergillus fumigatus to toxic compounds

SFB 987 Mini-Symposium

"Structure of bacterial secretion systems by cryo-EM"

Special seminar

Plant-derived regulators and their application in COMPASS optimization method

Marburger Yeast Club

How to get published in Nature Communications and other Nature journals

Special seminar

Specific integration and regulation of the prokaryotic-type protein synthesis machinery in chloroplasts of plants

Microbiology Seminar Series

Synthetic genomics: from genetic parts to genomes

Transregio TRR 174 Seminar

Surfing in the storm: Revealing biochemical networks of Burkholderiales to deal with toxic compounds and heavy metals

Special seminar

The Clockwork of Epigenetic Aging in Mammals

Special seminar

Sulfur incorporation into tRNA: Unique mechanistic features and functions in bacteria

SFB 987 Mini-Symposium

Replication control of multiple chromosomes in bacteria

Transregio TRR 174 Seminar

Computational modeling of metabolism in a minimal cell

Special seminar

Mechanosensing in cell membranes

Special seminar

Fungal-bacterial mutualistic interaction; fungal highway and bacterial toll

Mass spectrometric exploration of the proteotype

Microbiology Seminar Series

The evolution and functions of gut microbiota in bees

SFB 987 Mini-Symposium

Defining species in the microbial world

SFB 987 Mini-Symposium

Synthetic Gene-Metabolic Circuits for Bioproduction, Biosensing and Biocomputation

Special seminar

Robust and promiscuous monooxygenase biocatalysts - From discovery to design

Special seminar

Microbial mediation of folivory

Special seminar

Self-organization of the bacterial cell division machinery

Microbiology Seminar Series

Salmonella diarrhea: mucus barriers, hydrogen-fueled growth and DNA transfer in the gut

Microbiology Seminar Series

Permutation of Split Protein Cages

Special seminar

Cryo-EM gets sweet: Molecular insight into glycosylation

Special seminar

Toward artificial cells: Engineering synthetic membranes, organelles, gene circuits and communication

Special seminar

The burden of inherited interfaces: evolution of self-assembly after gene duplication

Microbiology Seminar Series

The ParA/MinD family of ATPases make waves to position DNA, Cell Division, & Organelles in bacteria

Special seminar

The MocR-like transcription factors: pyridoxal 5’-phosphate-dependent regulators of bacterial metabolism

SFB 987 Mini-Symposium

"It-Ma(t)Ter(s)" Conference

This is a joint young researcher's conference organized between the MPI for Terrestrial Microbiology and our partner MPI for Marine Microbiology in Bremen. [mehr]

Targeted Intracellular Delivery of Enzymes with Engineered AB5 Carriers

Special seminar

Unipolar growth of Brucella abortus in culture and inside host cells

Transregio TRR 174 Seminar

An optimized formate-assimilation pathway via enzyme engineering.

Special seminar

Understanding and exploiting bacterial lifestyles

Transregio TRR 174 Seminar

Pathogen effectors hitchhike the host ubiquitination pathway

SFB 987 Mini-Symposium

Towards synthetic life: Establishing a minimal segrosome for the rational design of biomimetic systems

PhD Defense

### Cancelled ###

Microbiology Seminar Series

To be announced

Transregio TRR 174 Seminar

Minimal metabolic engineering - getting the most bang for your buck

SFB 987 Mini-Symposium

Graduate Students Mini Symposium I/2019

Graduate Students Mini-Symposium

Organelle-like structures in Agrobacterium tumefaciens and Ralstonia eutropha

Transregio TRR 174 Seminar

A protein complex formed by Ustilago maydis effectors is essential for virulence (PhD Defense)

PhD Defense

Structural and Functional Characterization of Nucleic Acid Interacting Bacterial Stress Response Factors(PhD Defense)

PhD Defense

A new facet of vitamin B12: gene regulation by a novel and widespread family of adenosylcobalamin-dependent photoreceptors in bacteria

SFB 987 Mini-Symposium

Salmonella persisters during infection

C A N C E L E D - SFB 987 Mini-Symposium

The ParC/ ParP system in the localization and segregation of chemotaxis signaling arrays in Vibrio cholerae and Vibrio parahaemolyticus (PhD Defense)

PhD Defense

Graduate Students Mini-Symposium VI/2018

Graduate Students Mini-Symposium

Understanding cell division and its regulation in the human pathogenic bacterium, Vibrio parahaemolyticus (PhD Defense)

PhD Defense

Frontiers in Microbiology 2018

Special seminar

Frontiers in Microbiology 2018

Special seminar

RocS drives chromosome segregation and nucleoid protection during cell division of Streptococcus pneumoniae

Transregio TRR 174 Seminar

Mechanisms of co-translational folding and assembly of proteins studied by ribosome profiling

SFB 987 Mini-Symposium

Regulation of peptidoglycan biosynthesis in Hyphomonas neptunium (PhD Defense)

PhD Defense

Darwin’s invertebrates: A transient anoxic microbial oasis

MPI Seminar

Structural and mechanistic insights into the guanine nucleotide exchange factor complex Mon1-Ccz1

SFB 987 Mini-Symposium

Predator-prey interactions between the nematode-trapping fungi and nematodes

The networking of microbiomes across plant generations

SFB 987 Mini-Symposium

Methylotrophic methanogens everywhere - ecology and physiology of novel players in global methane cycling

SFB 987 Mini-Symposium

Structural insights into effector kinases from pathogenic gram-negative bacteria

SFB 987 Mini-Symposium

A Time to Kill: Mechanisms and Biological Insights of T6SS-Mediated Bacterial Warfare

How microorganisms view their world

SFB 987 Jahrestagung

The role of M23 peptidases on cell division and cell shape in Vibrio parahaemolyticus

Graduate Students Mini-Symposium

Regulatory circuits controlling the glycine betaine synthesizing pathway in Bacillus subtilis

Graduate Students Mini-Symposium

Proteomics - a new tool for type II methanotroph research

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium V/2018

Graduate Students Mini-Symposium

Heterogeneity of gene expression during biofilm formation in Escherichia coli

PhD Defense

In planta multi-omic profiling of pathogenic and commensal bacteria

Key proteins in the cell division of filamentous cyanobacteria

Transregio TRR 174 Seminar

Genomics of uncultivable bacteria deciphers multilayered symbiotic system in the termite gut

MPI Seminar

Establishing CO2 fixation pathways in Methylobacterium extorquens

Graduate Students Mini-Symposium

Evolution of a Non-natural Carboxylase for Synthetic Photorespiration

Graduate Students Mini-Symposium

Influence of cardiolipin on the function of bacterial chemoreceptors

Graduate Students Mini-Symposium

Determination of the substrate recognition by fumarate adding enzymes

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium IV/2018

Graduate Students Mini-Symposium

Control of reactive intermediates in enzymes and enzyme complexes

PhD Defense

New techniques in ultra high throughput directed evolution screens

Special seminar

α-Ketoglutarate dependent dioxygenases - computational studies on reaction mechanisms

SFB 987 Sonderseminar

A CTP-binding protein links the ParABS chromosome segregation system to the bactofilin cytoskeleton in Myxococcus xanthus

Graduate Students Mini-Symposium

Shedding Light on CETCH: Linking synthetic carbon fixation pathways to the energy produced by light powered thylakoids

Graduate Students Mini-Symposium

Biofilm architectural breakdown in response to antibiotics facilitates community invasion

Graduate Students Mini-Symposium

Characterization of DNA interference by a minimal Type I CRISPR-Cas system

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium III/2018

Graduate Students Mini-Symposium

Bacterial warfare: antibiotic production and resistance in co-existing Streptomycetes

SFB 987 Mini-Symposium

Mechanosensing with type IV pili in Pseudomonas aeruginosa

SFB 987 Mini-Symposium

High-throughput interaction profiling in bacteria

Microbiology Seminar Series

Unraveling the function of a stress sentinel in the bacterial envelope

Transregio TRR 174 Seminar

Bacterial chromosome organization

Microbiology Seminar Series

Microbial Dynamics at Biointerfaces: Controlling the Fate of Microbes under Spatial and Interfacial Confinements

Special seminar
Microbes self-organize in microcolonies at solid surfaces while transitioning to a sessile form within a protective biofilm matrix. Microbes also have complex community dynamics at fluid interfaces. While the biological implications of surface-attached and interfacial biofilms for the environment, health, and industry are widely appreciated, the earlier developmental stage of microbes as microcolonies has received scant attention. This presentation elucidates two new approaches to investigate microbial dynamics in spatially and interfacially confined microsystems. First, a new approach to studying microcolony formation and community dynamics is described. Using microfluidics-enabled fabrication, a nanoliter-scale sessile culture system (the nanoculture) is designed to grow synthetic microbial communities. Each nanoculture begins as a several nanoliter droplet of suspended cells, encapsulated by a polydimethylsiloxane (PDMS) membrane. The physicochemical properties of the encapsulation materials allow the diffusion of functional probes to interrogate cell physiology under chemical insults, allowing microbial interactions to be probed within or across the confining vessel. We use this versatile platform to investigate bacterial-fungal (inter-kingdom) dynamics that play a central role in early childhood dental caries and many infections. Second, microbial response to confinement at fluid-fluid interfaces are studied both in terms of physico-chemical effects and metabolic implications. We study two strains of P. aeruginosa, PAO1 and PA14. The PAO1 cells remodel the hexadecane-water interface to form highly elastic Films of Bacteria at Interfaces (FBI), i.e. elastic, solid films of bacteria and excreted polysaccharides, whereas the PA14 cells form active FBI that feature interface-associated microbes that remain highly motile. Transcriptional profiles of the interfacially confined strains suggest that the elastic FBI provides protection, in a manner akin to biofilms, enabling cells to cope with the detrimental effects of the interfacial environment. Together, these studies provide a basis for new strategies to minimize the deleterious impacts and to optimize the beneficial effects of microbial communities relevant to the environment and health. The nanoculture system and FBI-encapsulated droplets can also be exploited in upstream bioprocessing technologies, with uses ranging from the encapsulation of beneficial microbial communities to high-throughput screening of bioactive molecules. [mehr]

A circuitous route to mitochondrial acylation in regulation of oxidative phosphorylation

SFB 987 Mercator-Fellow Seminar

Synthetic biology: Putting synthesis into biology

Special Seminar - Univ. Marburg, FB Chemie und MPI Marburg

Chemotaxis of Escherichia coli to compounds present in human gut (PhD defense)

PhD Defense

Mechanisms of transmembrane signaling by sensors of two-component system

SFB 987 Mini-Symposium

Finally, archaea get their CRISPR-cas toolbox

SFB 987 Mini-Symposium

Synthetic noise control in eukaryotic gene expression and signal transduction (PhD Defense)

PhD Defense

Natural products in microbial predator-prey interactions

MPI Seminar

Viruses of Archaea: what we can learn from them

Special seminar

Exploring molecular landscapes inside cells with in situ cryo-electron tomography

Microbiology Seminar Series

High-resolution whole genome mapping of Sister Chromatid Contacts (Hi-SC2) in Vibrio cholerae

Transregio TRR 174 Seminar

Bacterial ribosome heterogeneity: Novel aspects of selective translation

SFB 987 Mini-Symposium

Activation of the bacterial stringent response

SFB 987 Mini-Symposium

Molecular tricks of methanogenic archaea

MPI Seminar

Physiology and cell biology of bacterial epithelia

Transregio TRR 174 Seminar

Symbioses as sources of evolutionary innovation in insects

Special seminar

From boom to bust - the dynamics of bacterial adaptation under prolonged resource limitation

SFB 987 Mini-Symposium

Unlocking the potential of synthetic biology - from DNA foundries to cell-free prototyping

SFB 987 Mini-Symposium

Genetic circuit design

SFB 987 Mini-Symposium

c-di-AMP signaling in Staphylococcus aureus: What makes, breaks and binds it

SFB 987 Mini-Symposium

Deadly conversation between bacteria

SFB 987 Mini-Symposium

Adaptive genome evolution in the vascular wilt pathogen Verticillium

MPI Seminar

D-Amino acids shape the environmental microbial biodiversity

MPI Seminar

Self-assembly of a bacterial nanomachine: Flagella grow through an injection-diffusion mechanism

SFB 987 Mini-Symposium

C A N C E L L E D Chemical interaction between iron-cycling microbes: news from the chat room

SFB 987 Mini-Symposium

Divorcing chromosomes still need rings: the role of an ancestral SMC protein in bacterial chromosome organisation and segregation

Transregio TRR 174 Seminar

Cross-Kingdom RNAi and small RNA trafficking between plants and fungal pathogens

Characterization of a Serine/Threonine kinase in Vibrio parahaemolyticus

Graduate Students Mini-Symposium

Architecture of Vibrio parahaemolyticus swarm-colonies

Graduate Students Mini-Symposium

Studies on catalytic mechanism of [Fe]-hydrogenase from methanogenic archaea

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium II/2018

Microbiology Seminar Series

*** CANCELED *** Visualizing and quantifying the selfish uptake of high molecular weight polysaccharides by marine bacteria

SFB 987 Mini-Symposium

Microbe-Electrode-Interactions

SFB 987 Mini-Symposium

Biochemistry of the key spatial regulators MipZ and PopZ in Caulobacter crescentus (PhD defence)

PhD Defense

The design and realization of synthetic pathways for the fixation of carbon dioxide in vitro (PhD defence)

PhD Defense

The seminar will start later (on 15:00 h) due to a snow storm in Munich "Architecture and biogenesis of an antibacterial speargun: the type VI secretion system"

Transregio TRR 174 Seminar

How proteins control electrons: Protons

MPI Seminar

Regulation of peptidoglycan biosynthesis in Hyphomonas neptunium

Graduate Students Mini-Symposium

Biochemistry of the key spatial regulators MipZ and PopZ in Caulobacter crescentus

Graduate Students Mini-Symposium

Shining light on the structural features of DNA repair in the PCSf

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium I/2018

Microbiology Seminar Series

Dormancy or growth under deep starvation conditions & Observing antimicrobial activities in single cells

SFB/Transregio TRR 174

SFB Mini Symposium

Microbiology Seminar Series

How to distribute multiple chromosomes along the hyphal cell?

SFB/Transregio TRR 174

Structure-function analysis of Cmu1, the secreted chorismate mutase from Ustilago maydis (PhD defense)

PhD Defense

Using images to understand structure, function and dynamics of Type VI secretion systems

Microbiology Seminar Series

SFB Mini Symposium

Microbiology Seminar Series

Studying the crossroads of iron metabolism and thiol redox balance

Special seminar

Structure, function, assembly and engineering of bacterial microcompartments

Microbiology Seminar Series

Elucidating the lipopolysaccharide biosynthetic pathway in Myxococcus xanthus

Graduate Students Mini-Symposium

Structural variation of type I-F CRISPR RNA guided DNA surveillance

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium VI/2017

Graduate Students Mini-Symposium

Hyphal growth in oscillation

SFB Mini Symposium

Microbiology Seminar Series

Northern wetlands: a world of unique microbes with difficult characters

SFB Mini Symposium

Cell-wall remodelling drives engulfment during sporulation in Bacillus subtilis

Microbiology Seminar Series

Solving the kinetochore structure of Schizosaccharomyces pombe with single molecules localization microscopy

Graduate Students Mini-Symposium

About the creation and isolation of switching metabolic enzymes

Graduate Students Mini-Symposium

Metatranscriptomics reveals drainage effects on paddy soil microbiome across all three domains of life

Graduate Students Mini-Symposium

Chemotaxis towards autoinducer 2 mediates intra- and interspecies behaviors of Escherichia coli

Graduate Students Mini-Symposium

C A N C E L L E D - Postponed to 20.11.2017

Microbiology Seminar Series

Stabilizing engineered microbial populations - about the benefit of being dynamic

Special seminar

SFB Mini Symposium

Microbiology Seminar Series

Degradation of aromatic compounds activates stress and reduces biofilm formation in bacteria

Special seminar

All you never wanted to know about cooperative 2-electron transitions but should definitely dare to ask

Microbiology Seminar Series

SFB Mini Symposium

Microbiology Seminar Series

Rhodopsins - the green light sensing component of the fungal eye

SFB Mini Symposium

In-House Career Day

TEM studies of plant-fungus interactions

Special seminar

Effector proteins from the rice blast fungus Magnaporthe oryzae provide novel insight into plant-pathogen interactions

Microbiology Seminar Series

Lantibiotic resistance in the human pathogen Streptococcus agalactiae

Microbiology Seminar Series

Speakers from Academia and Industry (see below)

Microbiology Seminar Series
Attendance at the symposium is free of charge, but registration is required. Please register here: http://synmikro.com/news/events/biofilms-in-nature-technology-and-medicine-symposium-2017/registration.html [mehr]

Redox-sensing mechanisms under infection conditions in Staphylococcus aureus

SFB Mini Symposium

SR1, the first dual-function sRNA from Bacillus subtilis. Base-pairing and peptide functions

SFB Mini Symposium

Plant developmental rewiring during the AM symbiosis

SFB Mini Symposium

Deviation from the norm: eukaryotic microbes with two kinds of nuclei and alternative genetic codes

Special seminar

The beauvericin cluster in Fusarium fujikuroi is controlled by a network of pathway-specific and global regulators

Microbiology Seminar Series: SFB Mini Symposium

Pseudomonas aeruginosa lifestyles, bacterial warfare and novel antimicrobials

Microbiology Seminar Series: SFB Mini Symposium

The hidden cost of enzyme catalysis

Microbiology Seminar Series

Establishing M. xanthus cell polarity

Graduate Students Mini-Symposium

Robust Population control in Synthetic Communities

Graduate Students Mini-Symposium

Graduate Students Mini Symposium IV/2017

Graduate Students Mini-Symposium

Tool engineering for synthetic microbial consortia for metabolic engineering

Graduate Students Mini-Symposium

Seeking intersections of microbiology, fluid mechanics, and physical chemistry

Special seminar
In this talk I describe various problems involving the intersections of fluid mechanics, bacterial biofilms and physical chemistry. I first highlight our studies of the influence of fluid motion on surface-attached bacteria and biofilms, where we identify and characterize upstream migration of surface-attached bacteria in a flow. Second, I highlight the influence of flow on quorum sensing, which refers to bacterial communication and collective behavior regulated by secreted chemicals. Our results suggest that bacterial colonization and biofilm development under flow can lead to heterogeneous QS activation, which promotes diversity in the genetic programs that bacteria enact. As a consequence, genetically identical bacteria exhibit different behaviours at particular regions and at particular times under flow. Finally, I describe an out-of-equilibrium consequence of concentration gradients, which, perhaps surprisingly, allow movement of particles (e.g. vesicles, DNA) in simple geometries. In particular, with salt gradients, via a mechanism referred to as diffusiophoresis, we can remove particles from dead-end pores or deliver particles into such pores. We explore the phenomenon using experiments and modeling. We close by posing the question if there might be broader consequences of these out-of-equilibrium physical chemistry ideas in biological contexts. [mehr]

Synthesis, import and export of ectoines

Graduate Students Mini-Symposium

Engineering of CO2 fixing reaction cascades to synthesize a diverse library of polyketide extender units

Graduate Students Mini-Symposium

Dynamic biofilm architecture confers individual and collective mechanisms of phage protection

Graduate Students Mini-Symposium

Towards biomimetic cell division: In vitro reconstitution of segregation

Graduate Students Mini-Symposium

Adhesins in Candida glabrata

Graduate Students Mini-Symposium

Graduate Students Mini Symposium III/2017

Graduate Students Mini-Symposium

Eyes of blue: Bacterial photoreceptors with multiple sensing and output functions

Microbiology Seminar Series: SFB Mini Symposium

Light and the life of bacteria - examples from Amsterdam

Microbiology Seminar Series: SFB Mini Symposium

Cell-states-dependent changes in cellular K+ determines protein activity in Escherichia coli

Graduate Students Mini-Symposium

Bacterial chemotaxis towards compounds in the gut

Graduate Students Mini-Symposium

Diversification of gene expression in Escherichia coli biofilms

Graduate Students Mini-Symposium

Functional characterization of a protein complex formed by four Ustilago maydis effectors essential for virulence

Graduate Students Mini-Symposium

Graduate Students Mini Symposium II/2017

Graduate Students Mini-Symposium

Effect of the environmental temperature on gene expression and motility system of E. coli¤

Graduate Students Mini-Symposium

The development of synthetic CO2 fixation pathways

Graduate Students Mini-Symposium

Coupling chemosensory array formation and localization

Graduate Students Mini-Symposium

Regulation of type IV pili asymmetry in Myxococcus xanthus¤

Graduate Students Mini-Symposium

Graduate Students Mini Symposium I/2017

Graduate Students Mini-Symposium

Noise control in signaling pathways

Graduate Students Mini-Symposium

Microbial symbionts of leaf-cutting ants (Atta and Acromyrmex)

Microbiology Seminar Series
Leaf-cutting ants harvest substantial amounts of leaf material to cultivate a specialized fungus for food (Leucoagaricus). This complex symbiosis includes at least four coevolved organisms: the farming ants, their fungal crop, a specialized mycoparasite of the ant’s fungal gardens (Escovopsis), and actinomycete bacteria (Pseudonocardia) that the ants culture on their bodies to obtain antibiotics against the parasites. We described an additional symbiosis with Nitrogen-fixing bacteria that colonize the fungus gardens and contribute to supplement the ants’ nutrition. Our present research efforts in Costa Rica focus on potential biotechnological applications of the ants’ microbial symbionts, including bioprospecting for new antibiotics and developing microbial-based biocontrol strategies. [mehr]

Metabolite cross-feeding in synthetic microbial communities: from ecology to biotechnological applications

Microbiology Seminar Series: SFB Mini Symposium

Drivers of assembly and coexistence in communities of arbuscular mycorrhizal fungi - the scale matters!

Microbiology Seminar Series: SFB Mini Symposium
Arbuscular mycorrhizal (AM) fungi are asexual, obligately symbiotic fungi with unique morphology and genomic structure, which occupy a dual niche, that is, the soil and the host root. Consequently, the direct adoption of models for community assembly developed for other organism groups is not evident. Based on recent studies using high throughput molecular methods and their findings, I will give an overview on the factors driving AM fungal community assembly at different scales. By synthesizing these findings, I will show how modern coexistence and assembly theory can be adapted to arbuscular mycorrhizal fungi and that hierarchical spatial structure of arbuscular mycorrhizal fungal communities should be explicitly taken into account in future studies. This conceptual framework developed for arbuscular mycorrhizal fungi is also adaptable for other host-associated microbial communities. [mehr]

Coevolutionary strategies in tripartite host-virus-virophage systems

Bacterial Modern Mass Spectrometric Methods in Life Science Research

Microbiology Seminar Series: SFB Mini Symposium

From commensalism to pathogenicity: stages of Candida albicans infections

Microbiology Seminar Series

Functional characterization of the Ustilago maydis virulence gene scp2 (PhD defense)

PhD Defense

Horizon 2020: Presentation on Grants of the European Research Council and Marie Curie Fellowships

Special seminar
„Horizon 2020” – The Framework Programme for Research and Innovation is the main financial instrument supporting European research. Running from 2014 to 2020 with an €77 billion budget, Horizon 2020 lays down the foundations for funding instruments that can be important for researchers of the Max Planck Institutes, such as Grants of the European Research Council or Marie Curie Fellowships. [mehr]

Ploidy in prokaryotes: On the seldom cases of monoploidy and the many evolutionary advantages of polyploidy

SFB Mini Symposium

Bacterial small RNAs in regulatory circuits: interplay with transcription factors and mechanistic insights

SFB Mini Symposium

Delivery and activity of Phytophthora effectors that suppress plant immunity

2nd Career Day

Special seminar
9:15 to 9:20Organizers of the 2nd Career DayWelcome9:20 to 9:55Dr. Thomas BühlerSenior Manager Analytical Services Quality - Microbiology (CSL Behring. Marburg, Germany)9:55 to 10:30Dr. Valeria GrassoPlant Pathologist (Syngenta Crop Protection AG. Stein, Switzerland)10:30 to 11:05Dr.-Ing. Ute DechertUnit Head Organisation & Processes (Brain AG. Zwingenberg, Germany)11:20 to 11:55Dr. Kerstin Lassak Trainee Patent Attorney (V.O. Patents & Trademarks. Munich, Germany)11:55 to 12:30Patricia Krause Senior Account Specialist Inhouse Services (Randstad. Marburg, Germany)13:30 to 14:05Dr. Carol Bacchus Vice President & Publishing Director, Research (Wiley-VCH Verlag GmbH & Co. KGaA. Weinheim, Germany)14:05 to 14:40Aileen D’Oria Recruiter - Talent Acquisition EMEA (Thermo Fisher Scientific, Darmstadt, Germany)14:55 to 15:30Thomas Glaeser Senior Recruiter EMEA (Leica Microsystems CMS GmbH. Wetzlar, Germany)15:30 to 16:05Dr. Tomasz Neiner Change Control Specialist (Abbott. Wiesbaden, Germany)16:05 to 16:15Concluding remarks [mehr]

The NAD-dependent FdsABG formate dehydrogenase from Cupriavidus necators

Special seminar

Inverse toeprinting - A new, high-throughput method for identifying and characterizing ribosome arresting peptides

SFB Mini Symposium

Signal transduction by reversible protein phosphorylation in the third domain of life

SFB Mini Symposium

Last but not least – Late cell division proteins in Caulobacter crescentus (PhD defense)

PhD Defense

Sex pheromones and conjugation in gram-positive bacteria

SFB Mini Symposium

Sweets for my sweet: Carbohydrate transport and its regulation in Sulfolobus acidocaldarius (PhD defense)

PhD Defense

Control of morphogenesis in the budding Alphaproteobacterium Hyphomonas neptunium (PhD defense)

PhD Defense

Bacterial chemoreceptors: diversity and conservation

Special seminar

Deconstructing cell-size control into physiological modules in E. coli

Special seminar

Bacterial chemoreceptors: diversity and conservation

Special seminar

The evolution of symbiosis in cockroaches: a genomic and phylogenetic perspective

Synchronization of synthetic gene oscillators

Chromosome arrangement and dynamics in the budding bacterium Hyphomonas neptunium (PhD defense)

PhD Defense

Oxidoreductases for biocatalysis - from screening to function

Mechanisms and regulation of bacterial cell wall growth

How are Fe-S cofactors and proteins assembled in plant cells?: Focus on the late steps of the maturation process in organelles

Great Idea! Patent it! - Inhouse seminar on patents

Special seminar

Skin Microbial Endocrinology: When host neurohormones control bacterial homeostasis

Assembly and mechanism of respiratory complex I

SFB Mini Symposium

Structure of mitochondrial complex I

SFB Mini Symposium

Regulation of phototaxis in cyanobacteria and how a small cell can detect the direction of light

SFB Mini Symposium

Super complex formation of the denitirification respirasome of Pseudomonas aeruginosa

SFB Mini Symposium

Metabolic lifestyle and energy conservation tricks of giant, symbiotic bacteria – the special case of Epulopiscium

Special seminar

The physical ecology of (marine) microbes

Pan-archaeal analysis of C/D box sRNA biogenesis and methylation targets (PhD Defense)

PhD Defense

Light controlled self-assembly

Special seminar

Key microbial players for the bioremediation of petroleum hydrocarbons

Special seminar

Mechanistic and evolutionary aspects of gene expression noise in yeast

Biophysics of Biofilms

Antrittsvorlesung

Bacteria cell shape memory under mechanical stress: Residual strains regulate rod-like cell shape in bacteria

Special seminar

Oomycete infections of fish

Special seminar

Systems biology approaches to dissecting plant cell wall deconstruction by a filamentous fungus

Special seminar
Transmembrane chemoreceptors are central components in the sensory system that mediates bacterial chemotaxis. Like many transmembrane proteins, these receptors are fully active only if inserted in a lipid bilayer. This requirement presents a challenge for in vitro analysis by many biochemical and structural techniques. The challenge is met by Nanodiscs, soluble, nanoscale (~10 nm diameter) particles of lipid bilayer surrounded by an annulus of amphipathic protein into which transmembrane proteins can be incorporated. Using Nanodiscs, we documented that chemoreceptor dimers bend at a specific locus along their 300 Å long axis, discovered that conformational differences between chemoreceptor signalling states were differential propensities of receptor helices to become momentarily unstructured, and determined that chemoreceptor signalling complexes activate and control the chemotaxis histidine kinase by altering its catalytic rate constant. [mehr]

Physiology and proteomics of marine heterotrophic bacteria

Comprehensive analysis of peptidoglycan hydrolases in Caulobacter crescentus (PhD Defense)

PhD Defense

Bacterial-fungal interactions in decaying wood: diversity and contribution to biogeochemical cycles

Special seminar

Characterization of the division apparatus in the budding bacterium Hyphomonas neptunium (PhD defense)

PhD Defense

Characterization of RomX and RomY, two novel motility regulators in Myxococcus xanthus

Graduate Students Mini-Symposium

Control of cell division during development of Myxococcus xanthus

Graduate Students Mini-Symposium

Structure-function analysis of Cmu1, a secreted chorismate mutase in Ustilago maydis

Graduate Students Mini-Symposium

The effector protein Ten1 of Ustilago maydis

Graduate Students Mini-Symposium

Insights into the small RNA interactome of Sulfolobus acidocaldarius

Graduate Students Mini-Symposium

Physicochemical conditions and microbial community structure in the guts of lignocellulose feeding cockroaches

Graduate Students Mini-Symposium

Microbial interactions from a molecular and evolutionary perspective

SFB Mini Symposium

The Integron: Adaptation on demand

SFB Mini Symposium

Sugar influx sensing by the phosphotransferase system of Escherichia coli

Graduate Students Mini-Symposium

Structure and biochemical studies on biosynthesis of the [Fe]-hydrogenase cofactor

Graduate Students Mini-Symposium

Genomics-enabled natural product discovery

Natural products have been, without question, the most prolific source of all medicines, especially antibiotics. Genome sequencing has revealed that our knowledge of natural product structure and function is astonishingly incomplete. Therefore, exploration of uncharted natural product chemical space will undoubtedly lead to improved, and entirely new, medicines. Against this backdrop, our group focuses on elucidating the biosynthesis, structure, and function of natural products. This talk will highlight our recent advances in genomics-enabled natural product discovery while covering a few case studies in enzymatic biosynthesis that could be exploited to introduce new drug leads. [mehr]

Understanding activation bacterial promoters

SFB Mini Symposium

Global reprogramming of the Yersinia pseudotuberculosis transcriptional landscape in response to temperature and host signals

SFB Mini Symposium

Oxymonads – eukaryotes without mitochondrion

Mitochondrion is a key evolutionary inventions specific to the eukaryotic cell. Oxymonads remained as one of a few eukaryotic groups, where no mitochondrion has been revealed so far. We have performed detailed genomic and transcriptomic study of oxymonad Monocercomonoides sp., which demonstrates the absence of mitochondrial hallmark proteins. The most striking is the absence of canonical mitochondrial protein import machinery and the substitution of mitochondrial iron sulphur cluster biosynthetic pathway (ISC) by the sulphur mobilization system (SUF). We conclude that Monocercomonoides represents the first report of amitochondriate eukaryote demonstrating the fact that under some circumstances eukaryotes may entirely loose mitochondrion. [mehr]

From ancient lipids to synthetic life

The function of the cell membrane as a barrier and a matrix for biochemical activity relies on the properties imparted by lipids. In eukaryotes, sterols are crucial for modulating the molecular order of membranes. Sterol ordering provides the basis for membrane lateral segregation and promotes a fluid, mechanically robust plasma membrane. How do organisms that lack sterols determine membrane order? Hopanoids are ancient bacterial membrane lipids that have been proposed as putative sterol surrogates. We now explore the role of hopanoids, their effect on membranes in Methylobacterium extorquens and reflect on the path to building functional synthetic membranes. [mehr]

Modeling chemotactic pattern formation in E. coli bacteria

Linking metabolic and cell cycle regulation

The cell division cycle consists of a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell cycle. I will present our recent findings that over half of all measured metabolites change significantly through the cell division cycle. We find that the cyclin-dependent kinase Cdk1, a major cell cycle regulator, also controls carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. This demonstrates how cell cycle regulation can entrain carbon metabolism to dynamically fuel biosynthesis during proliferation. [mehr]

Together we are stronger: adaptive benefits drive a division of metabolic labour in bacteria

SFB Mini Symposium

Sensing and responding: Terrein production in Aspergillus terreus

SFB Mini Symposium

Bacterial shapeshifting: Escherichia coli differentiation during urinary tract infection

Urinary tract infections are caused primarily by uropathogenic strains of Escherichia coli (UPEC). UPEC is known to transition through a series of distinct infection stages, displaying reversible morphological differentiation along the way. Initial steps involve bladder invasion by rod-shaped bacteria to establish intracellular bacterial communities consisting of coccoid cells. Subsequently, during exit from infected cells, UPEC regain their rod-shape and in some cases even form large filaments. Using a flow-chamber based tissue culture infection model we have studied UPEC gene expression during the course of infection. Our results reveal a novel SOS-independent mechanism of reversible cell-division control. [mehr]

Cell wall stress sensing in the Gram-negative pathogen Vibrio cholerae

Cell wall adhesins in fungal pathogens: A sticky business

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