Mechanisms and regulation of bacterial cell wall growth

  • Datum: 25.07.2016
  • Uhrzeit: 13:15
  • Vortragende(r): Prof. Dr. Waldemar Vollmer
  • Institute for Cell and Molecular Biosciences, Newcastle University, UK
  • Ort: MPI for Terrestrial Microbiology
  • Raum: Lecture hall
  • Gastgeber: IMPRS
  • Kontakt:

Gram-negative bacteria have in their periplasm a single-layered peptidoglycan (PG) sacculus that protects the cell from bursting and is required to maintain cell shape. During growth and cell division the sacculus grows by the coordinated activities of PG synthases and hydrolases forming dynamic trans-envelope complexes. However, the molecular mechanisms of PG growth are poorly understood. I will present recent data on the activities and interactions of PG enzymes, and the regulation of PG synthesis by outer-membrane anchored lipoproteins. I will also discuss how bacteria maintain robust cell wall growth under different growth conditions that effect the properties of the periplasm.

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