Complex Adaptive Traits (CATs)

Complex Adaptive Traits (CATs)

Dr. Ilka Bischofs-Pfeifer

Research area

The Bischofs lab studies complex adaptive traits (CATs) of stressed bacteria. Our goals are to understand, to control and to engineer such traits. Using tools from molecular biology, microscopy and mathematical modelling we investigate how signaling networks regulate CATs. We seek to reveal fundamental organizing principles that relate the molecular network design to population-level behavior and vice versa. This should facilitate rational manipulations of bacterial populations and the implementation of novel functionalities into “smart” communities in the future.

Please visit also our website at the BioQuant of the University of Heidelberg.

Selected recent publications

A. Mutlu, S. Trauth, M. Ziesack, K. Nagler, J.-P. Bergeest, K. Rohr, N. Becker, T. Höfer and I.B. Bischofs (2018)
Phenotypic Memory in Bacillus subtilis links dormancy entry and exit by a spore quantity-quality tradeoff. Nature Communication 6: 69

H. Babel and I.B. Bischofs (2016)
Molecular and Cellular Factors Control Signal Transduction via Switchable Allosteric Modulator Proteins (SAMPs). BMC Systems Biology 10:35

D. Wolf, V. Rippa, J.C. Mobarec, P.Sauer, L. Adlung, P. Kolb and I. B. Bischofs (2016)
The quorum sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs. Nucleic Acids Research 44 (5), 2160-2172.

S. Pande, S. Shitut, L. Freund, M. Westermann, F. Bertels, C. Colesie, I. B. Bischofs and C. Kost (2015)
Metabolic cross-feeding via inter-cellular nanotubes among bacteria. Nature Communications 6: 6238

B. Drees, M. Reiger, K. Jung and I.B. Bischofs (2014)
A Modular View of the Diversity of Cell-Density-Encoding Schemes in Bacterial Quorum-Sensing Systems 
Biophysical Journal 107, 266-277

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