Transmission modes in two-component systems

Microbiology Seminar Series

  • Datum: 01.11.2021
  • Uhrzeit: 16:00
  • Vortragender: Felipe Trajtenberg, PhD
  • Institut Pasteur de Montevideo, Uruguay
  • Ort: Online
  • Gastgeber: Dr. Ilka Bischofs-Pfeifer
  • Kontakt:

Cellular signaling systems transmit information over long distances using allosteric transitions and/or post-translational modifications. In two-component systems the sensor histidine kinase and response regulator are wired through phosphoryl-transfer reactions, using either a unidirectional or bi-directional transmission mode, allowing building richer regulatory networks. I will present our recent advances in understanding the molecular determinants that allow these bacterial signaling pathways to efficiently transmit information minimizing cellular energy waste.

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