Linking metabolic and cell cycle regulation

  • Datum: 01.02.2016
  • Uhrzeit: 13:15
  • Vortragende(r): Dr. Jennifer Ewald
  • Department of Cell Cycle Control, Stanford University, USA
  • Ort: MPI for Terrestrial Microbiology
  • Raum: Lecture hall
  • Gastgeber: Dr. Hannes Link
  • Kontakt:
The cell division cycle consists of a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell cycle. I will present our recent findings that over half of all measured metabolites change significantly through the cell division cycle. We find that the cyclin-dependent kinase Cdk1, a major cell cycle regulator, also controls carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. This demonstrates how cell cycle regulation can entrain carbon metabolism to dynamically fuel biosynthesis during proliferation.
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