Hydride intermediates in the catalytic turnover of gas-processing metalloenzymes from diverse microorganisms

Microbiology Seminar Series

  • Datum: 10.07.2023
  • Uhrzeit: 13:15
  • Vortragende(r): Dr. Sven Stripp
  • Technische Universität Berlin, Division of Physical Chemistry
  • Ort: MPI for Terrestrial Microbiology
  • Raum: Lecture Hall / Hybrid
  • Gastgeber: Dr. Johannes Rebelein
  • Kontakt: johannes.rebelein@mpi-marburg.mpg.de

Understanding the structure and molecular mechanism of low-valent gas-processing metalloenzymes (GPMs) inspires the design of synthetic catalysts for H2 production, N2 fixation, and the removal of CO2 from the atmosphere.

Based on insight from structural biology and vibrational spectroscopy, I will discuss the molecular mechanism of GPMs like hydrogenase and nitrogenase. Second and outer coordination sphere effects critically promote metal-hydride species that are key to H2 production with zero electric overpotential and N2 fixation under ambient conditions. While typically O2-senstitive, the combination of high substrate affinity and dynamic gas filtering enables certain hydrogenases to catalyse H2 oxidation “out of thin air” (pH2 <0.00005%).

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