Bacterial shapeshifting: Escherichia coli differentiation during urinary tract infection

  • Datum: 18.01.2016
  • Uhrzeit: 13:15
  • Vortragende(r): Dr. Jakob Møller-Jensen
  • Department of Biochemistry and Molecular Biology, University of Southern Denmark
  • Ort: MPI for Terrestrial Microbiology
  • Raum: Lecture hall
  • Gastgeber: Dr. Simon Ringgaard
  • Kontakt:
Urinary tract infections are caused primarily by uropathogenic strains of Escherichia coli (UPEC). UPEC is known to transition through a series of distinct infection stages, displaying reversible morphological differentiation along the way. Initial steps involve bladder invasion by rod-shaped bacteria to establish intracellular bacterial communities consisting of coccoid cells. Subsequently, during exit from infected cells, UPEC regain their rod-shape and in some cases even form large filaments. Using a flow-chamber based tissue culture infection model we have studied UPEC gene expression during the course of infection. Our results reveal a novel SOS-independent mechanism of reversible cell-division control.
Zur Redakteursansicht