Control of cell division during development of Myxococcus xanthus

Graduate Students Mini-Symposium

  • Datum: 18.04.2016
  • Uhrzeit: 15:50
  • Vortragende(r): Sabrina Huneke
  • MPI / Dept of Ecophysiology
  • Ort: MPI for Terrestrial Microbiology
  • Raum: Lecture hall
  • Gastgeber: Prof. Dr. L. Søgaard-Andersen
  • Kontakt:
In response to starvation M. xanthus initiates a developmental program thatleads to the formation of spore-filled fruiting bodies. Spores have beenreported to be diploid suggesting that cell division is inhibited during sporedifferentiation. We confirmed that spores contain two fully duplicatedchromosomes. To address regulation of cell division during sporulation, wefocused on the key cell division protein FtsZ. By analyzing FtsZ synthesis,degradation and accumulation we demonstrate that proteolysis of FtsZoutperform FtsZ synthesis during development resulting in elimination of FtsZand inhibition of cell division. Thus, regulated synthesis and constitutiveproteolysis enable cells to precisely modulate the accumulation of a keyprotein in response to environmental changes.
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