Core Facility for Metabolomics and small molecules MS
The Metabolomics Core Facility offers LC-MS services, access to equipment for sample preparation and a comprehensive set of tools for reliable data analysis based on a statistical evaluation. Moreover, to address the needs in this fast changing field, the Metabolomics Core Facility continuously develops new and tailor-made methods to address upcoming analytical questions. This includes targeted and non-targeted LC-MS analyses, semi-quantification and absolute quantification of metabolites extracted from several sample types, including mammalian cells, bacteria, yeast, body fluids and soft tissues. We host four cutting-edge LC-MS systems of different types to address each analytical question by the most suitable approach. Using state-of-the-art technologies and standardized laboratory protocols, the Metabolomics Core Facility strives to offer high quality mass spectrometry-based measurements of a wide range of small molecules in biologically relevant samples.
HAPPY - High-throughput APPlication for replicative lifespan determination in Yeast
The single cell organism Saccharomyces cerevisiae is an important industrial production organism and a powerful model organism in research. The determination of its age is thus of high relevance in many areas. We developed a microfluidic technology to determine the age of yeast cell in a high-throughput way. Thus, lifespan becomes an accessible optimization parameter in strain development, and as screening parameter for drug development for the first time.