Prof. Dr. Tobias Erb

Understanding and Building Metabolism

Curriculum Vitae

Tobias Jürgen Erb (born 1979)
Diploma in Biology, University of Freiburg (D), 2005
Magister scientiarum in Chemistry & Biology, University of Freiburg (D), 2005
Visiting scholar, The Ohio State University (US), 2007
Dr. rer. nat., Institute of Microbiology, University of Freiburg (D), 2009
DFG-Postdoctoral fellow, University of Illinois (US), 2009-2011
ETH-Fellow, Institute of Microbiology, ETH Zürich (CH), 2011-2012
Jr. Group leader & SNF-Ambizione fellow, ETH Zürich (CH), 2012-2014
Elected member of the Junge Akademie at the BBAW and Leopoldina 2013
Max Planck Research Group Leader (free floater) at the MPI Marburg, 2014-2017
Director and Head of the Department of Biochemistry and Synthetic Metabolism at the MPI Marburg, since 2017

Research area: Understanding and building metabolism

Metabolism is one of the key features of living systems. In our everyday life we experience it in different forms: Plants, algae and many microorganism perform photosynthesis and convert carbon dioxide into carbohydrates. Other organisms (including us humans) consume the fixed carbon to cover their energetic needs, which closes the global cycle of carbon.

From a scientific point of view, metabolism can be defined as the dynamic biochemistry of life that provides cells with the energy and the building blocks required for their three- and four-dimensional self-organization.

In our lab, we aim at understanding and applying the fundamental design principles of metabolism. On the one hand, we study the function and organization of natural metabolism in the context of the living cell. On the other hand, we use our understanding to build novel, synthetic metabolism in a bottom-up fashion.

Selected Publications

Schwander, T., Schada von Borzyskowski, L., Burgener, S., Cortina, N.S., and *Erb, T.J. (2016) A synthetic pathway for the fixation of carbon dioxide in vitro. Science 354:901-904 http://science.sciencemag.org/content/354/6314/900

Rosenthal, R.G., Vögeli, B., Quade, N., Capitani, G., Kiefer, P., Vorholt, J.A., Ebert, M.-O., and *Erb, T.J. (2015) The use of ene adducts to study and engineer enoyl-thioester reductases. Nature Chemical Biology 11:398-400 http://www.nature.com/nchembio/journal/v11/n6/full/nchembio.1794.html

Könneke, M., Schubert, D.M., Brown, P.C., Hügler, M., Standfest, S., Schwander, T., Schada von Borzyskowski, L., Erb, T.J., Stahl, D.A. and Berg, I.A. (2014) Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation. Proceedings of the National Academy of Sciences 111:8239-8244 http://www.pnas.org/content/111/22/8239

Rosenthal, R.G., Ebert, M.-O., Kiefer, P., Peter, D.M., Vorholt, J.A. and *Erb, T.J. (2014) Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes. Nature Chemical Biology 10:50-55 http://www.nature.com/nchembio/journal/v10/n1/abs/nchembio.1385.html

Erb, T.J., Evans, B.S., Kyuil, C., Warlick, B.P., Sriram, J., Wood, B.M., Sweedler, J.V., Tabita, F.R., Gerlt, J.A. (2012). A RubisCO-like protein links SAM metabolism and isoprenoid biosynthesis. Nature Chemical Biology 8:926-923 http://www.nature.com/nchembio/journal/v8/n11/full/nchembio.1087.html

*Erb, T.J., Kiefer, P., Hattendorf, B., Günther, D., Vorholt, J.A. (2012) GFAJ-1 is an arsenate resistant, phosphate dependent organism. Science 337:467-70 http://science.sciencemag.org/content/early/2012/07/06/science.1218455