Publications of Georg K. A. Hochberg

Ramírez-Amador, F.; Paul, S.; Kumar, A.; Lorent, C.; Keller, S.; Bohn, S.; Nguyen, T.; Lometto, S.; Vlegels, D.; Kahnt, J. et al.; Deobald, D.; Abendroth, F.; Vázquez, O.; Hochberg, G. K. A.; Scheller, S.; Stripp, S. T.; Schuller, J. M.: Structure of the ATP-driven methyl-coenzyme M reductase activation complex. Nature (2025)

Zheng, L.; Du, Y.; Steinchen, W.; Girbig, M.; Abendroth, F.; Jalomo-Khayrova, E.; Bedrunka, P.; Bekeredjian-Ding, I.; Mais, C.-N.; Hochberg, G. K. A. et al.; Freitag, J.; Bange, G.: Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex. Nature Communications 16 (1), 2557 (2025)

Ries, F.; Gorlt, J.; Kaiser, S.; Scherer, V.; Seydel, C.; Nguyen, S.; Klingl, A.; Legen, J.; Schmitz-Linneweber, C.; Plaggenborg, H. et al.; Ng, J. Z. Y.; Wiens, D.; Hochberg, G. K. A.; Räschle, M.; Möhlmann, T.; Scheuring, D.; Willmund, F.: A truncated variant of the ribosome-associated trigger factor specifically contributes to plant chloroplast ribosome biogenesis. Nature Communications 16 (1), 629 (2025)

Schulz, L.; Zarzycki, J.; Steinchen, W.; Hochberg, G. K. A.; Erb, T. J.: Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes. The EMBO Journal 44, pp. 269 - 280 (2025)

Sendker, F. L.; Schlotthauer, T. J.; Mais, C.-N.; Lo, Y. K.; Girbig, M.; Bohn, S.; Heimerl, T.; Schindler, D.; Weinstein, A.; Metzger, B. P. H. et al.; Thornton, J. W.; Pillai, A.; Bange, G.; Schuller, J. M.; Hochberg, G. K. A.: Frequent transitions in self-assembly across the evolution of a central metabolic enzyme. Nature Communications 15 (1), 10515 (2024)

Gao, Y.; Tan, D. S.; Girbig, M.; Hu, H.; Zhou, X.; Xie, Q.; Yeung, S. W.; Lee, K. S.; Ho, S. Y.; Cojocaru, V. et al.; Yan, J.; Hochberg, G. K. A.; de Mendoza, A.; Jauch, R.: The emergence of Sox and POU transcription factors predates the origins of animal stem cells. Nature Communications 15 (1), 9868 (2024)

Bozhüyük, K. A. J.; Präve, L.; Kegler, C.; Schenk, L.; Kaiser, S.; Schelhas, C. S.; Shi, Y.-N.; Kuttenlochner, W.; Schreiber, M.; Kandler, J. et al.; Alanjary, M.; Mohiuddin, T. M.; Groll, M.; Hochberg, G. K. A.; Bode, H. B.: Evolution-inspired engineering of nonribosomal peptide synthetases. Science 383 (6689), eadg4320 (2024)

Čepaitė, R.; Klein, N.; Mikšys, A.; Camara-Wilpert, S.; Ragožius, V.; Benz, F.; Skorupskaitė, A.; Becker, H.; Žvejytė, G.; Steube, N. B. et al.; Hochberg, G. K. A.; Randau, L.; Pinilla-Redondo, R.; Malinauskaitė, L.; Pausch, P.: Structural variation of types IV-A1- and IV-A3-mediated CRISPR interference. Nature Communications 15 (1), 9306 (2024)

Lago-Maciel, A.; Soares, J. C.; Zarzycki, J.; Buchanan, C. J.; Reif-Trauttmansdorff, T.; Schmidt, F. V.; Lometto, S.; Paczia, N.; Schuller, J. M.; Hansen, D. F. et al.; Heller, G. T.; Prinz, S.; Hochberg, G. K. A.; Pierik, A. J.; Rebelein, J. G.: Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage. bioRxiv: the preprint server for biology, 2024.10.19.619033 (2024)

Lometto, S.; Sparvoli, D.; Malengo, G.; Heimerl, T.; Hochberg, G. K. A.: The mitochondrial citrate synthase from Tetrahymena thermophila does not form an intermediate filament. European Journal of Protistology 96, 126121 (2024)

Garg, S.; Hochberg, G. K. A.: A general substitution matrix for structural phylogenetics. bioRxiv: the preprint server for biology, 2024.09.19.613819 (2024)

Peña-Diaz, P.; Braymer, J. J.; Vacek, V.; Zelená, M.; Lometto, S.; Mais, C.-N.; Hrdý, I.; Treitli, S. C.; Hochberg, G. K. A.; Py, B. et al.; Lill, R.; Hampl, V.: Characterization of the SUF FeS cluster synthesis machinery in the amitochondriate eukaryote Monocercomonoides exilis. Current Biology 34 (17), S0960-9822(24)00921-7, pp. 3855 - 3865.e7 (2024)

Sendker, F. L.; Lo, Y. K.; Heimerl, T.; Bohn, S.; Persson, L. J.; Mais, C.-N.; Sadowska, W.; Paczia, N.; Nußbaum, E.; del Carmen Sánchez Olmos, M. et al.; Forchhammer, K.; Schindler, D.; Erb, T. J.; Benesch, J. L. P.; Marklund, E. G.; Bange, G.; Schuller, J. M.; Hochberg, G. K. A.: Emergence of fractal geometries in the evolution of a metabolic enzyme. Nature 628 (8009), pp. 894 - 900 (2024)

Addison, H. G.; Glatter, T.; Hochberg, G. K. A.; Rebelein, J. G.: Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus. mBio 15 (3), e0331423 (2024)

Jakob, S.; Steinchen, W.; Hanßmann, J.; Rosum, J.; Langenfeld, K.; Osorio-Valeriano, M.; Steube, N.; Giammarinaro, P. I.; Hochberg, G. K. A.; Glatter, T. et al.; Bange, G.; Diepold, A.; Thanbichler, M.: The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression. Nature Communications 15 (1), 318 (2024)

Carreira, L. A. M.; Szadkowski, D.; Lometto, S.; Hochberg, G. K. A.; Søgaard-Andersen, L.: Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus. Nature Communications 14 (1), 4056 (2023)

Kremer, K.; Meier, D.; Theis, L.; Miller, S.; Rost-Nasshan, A.; Naing, Y. T.; Zarzycki, J.; Paczia, N.; Serrania, J.; Blumenkamp, P. et al.; Goesmann, A.; Becker, A.; Thanbichler, M.; Hochberg, G. K. A.; Carter, M. S.; Erb, T. J.: Functional degeneracy in Paracoccus denitrificans Pd1222 is coordinated via RamB, which links expression of the Glyoxylate cycle to activity of the Ethylmalonyl-CoA pathway. Applied and Environmental Microbiology 89 (7), e0023823 (2023)

Winiarska, A.; Ramírez-Amador, F.; Hege, D.; Gemmecker, Y.; Prinz, S.; Hochberg, G. K. A.; Heider, J.; Szaleniec, M.; Schuller, J. M.: A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire. Science Advances 9 (22), eadg6689 (2023)

Islam, M. I.; Ridone, P.; Lin, A.; Michie, K. A.; Matzke, N. J.; Hochberg, G. K. A.; Baker, M. A. B.: Ancestral reconstruction of the MotA stator subunit reveals that conserved residues far from the pore are required to drive flagellar motility. microLife 4, uqad011 (2023)

Moldenhauer, M.; Tseng, H.-W.; Kraskov, A.; Tavraz, N. N.; Yaroshevich, I. A.; Hildebrandt, P.; Sluchanko, N. N.; Hochberg, G. A.; Essen, L.-O.; Budisa, N. et al.; Korf, L.; Maksimov, E. G.; Friedrich, T.: Parameterization of a single H-bond in orange carotenoid protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems. Frontiers in Molecular Biosciences 10, 1072606 (2023)