The cell division cycle consists of a sequence of processes whose specific
demands for biosynthetic precursors and energy place dynamic requirements
on metabolism. However, little is known about how metabolic fluxes are
coordinated with the cell cycle. I will present our recent findings that over half
of all measured metabolites change significantly through the cell division cycle.
We find that the cyclin-dependent kinase Cdk1, a major cell cycle regulator,
also controls carbon metabolism. Trehalose utilization fuels anabolic
processes required to reliably complete cell division. This demonstrates how
cell cycle regulation can entrain carbon metabolism to dynamically fuel
biosynthesis during proliferation.
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