Publications

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


2019

Thauer, R.K. (2019)
Methyl (Alkyl)-Coenzyme M Reductases: Nickel F-430-Containing Enzymes Involved in Anaerobic Methane Formation and in Anaerobic Oxidation of Methane or of Short Chain Alkanes. Biochemistry. 2019 Apr 5. doi: 10.1021/acs.biochem.9b00164

2018

Buckel, W. & Thauer, R. K. (2018)
Flavin-based electron bifurcation, ferredoxin, flavodoxin and anaerobic respiration with protons (Ech) or NAD+ (Rnf) as electron acceptors: A historical review. Frontiers in Microbiology, Volume 9, Article 401, 1-24. DOI: 10.3389/fmicb.2018.00401

Buckel, W. & Thauer, R. K. (2018)
Flavin-based electron bifurcation, a new mechanism of biological energy coupling. Chemical Reviews 118, 3862-3886. DOI: 10.1021/acs.chemrev.7b00707 

Wellmer, F. W., Buchholz, P., Gutzner, J., Hagelüken, C.,  Herzig, P., Littke, R. & Thauer, R. K. (2018)
Raw material for future energy supply. Springer. ISBN 978-3-319-91228-8

2017

Thauer, R. K. (2017)
Lothar Jaenicke and C-1-metabolism: his first 25 years of research. Zeitschrift für Naturforschung Section C – A Journal of Biosciences 72, 237-243.  DOI: 10.1515/znc-2017-0108

Antranikian, G., Suleiman, M., Schäfers, C., Adams, M. W. W., Bartolucci, S., Blamey, J. M., Birkeland, N. K., Bonch-Osmolovskaya, E., da Costa, M. S., Cowan, D. Danson, M., Forterre, P., Kelly, R., Ishino, Y., Littlechild, J., Moracci, M., Noll, K., Oshima, T. Robb, F., Rossi, M., Santos, H., Schönheit, P., Sterner, R., Thauer, R. K., Thomm, M., Wiegel, J. & Stetter, K. O. (2017)
Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island. Extremophiles 21, 733-742. DOI 10.1007/s00792-017-0938-y

Martin, W. F. & Thauer, R. K. (2017) 
Energy in ancient metabolism. Cell 168, 953-955. DOI: 10.1016/j.cell.2017.02.032

Angerer, G., Buchholz, P.,  Erlach, B., Fuss, S., Gutzmer, J., Hagelüken, C., Haucap, J., Herzig, P., Kulik, J., Littke, R., Posch, P. N., Thauer, R. K. & Wellmer, F.W.  (2017)
Rohstoffe für die Energiewende: Wege zu einer sicheren und nachhaltigen Versorgung. 104 Seiten. Stellungnahme der Nationalen Akademie der Wissenschaften Leopoldina, der acatech – Deutsche Akademie der Technikwissenschaften und der Union der deutschen Akademien der Wissenschaften. http://dnb.d-nb.de (ISBN: 978-3-8047-3664-1)

2016

Angerer, G., Buchholz, P., Gutzmer, J., Hagelüken, C., Herzig, P., Littke, R., Thauer, R. K. & Wellmer, F.W.  (2016)
Rohstoffe für die Energieversorgung der Zukunft: Geologie – Märkte – Umwelteinflüsse. 197 Seiten.  Eine Analyse in der Schriftenreihe Energiesysteme der Zukunft  der Nationalen Akademie der Wissenschaften Leopoldina, der acatech – Deutsche Akademie der Technikwissenschaften und der Union der deutschen Akademien der Wissenschaften.  http://dnb.d-nb.de  (ISBN: 978-3-9817048-6-0)

Duin, E. C., Wagner, T., Shima, S., Prakash, D., Cronin, B., Yáñez-Ruiz, D. R., Duval, S., Rumbeli, R., Stemmler, R. T., Thauer, R. K. & Kindermann, M. (2016)
Mode of action uncovered for the specific reduction of methane emissions from ruminants by the small molecule 3-nitrooxypropanol. Proc. Natl. Acad. Sci. USA, 113, 6172-6177. DOI:10.1073/pnas.1600298113

2015

Thauer, R. K. (2015)
My lifelong passion for biochemistry and anaerobic microorganisms. Annual Review of Microbiology 69, 1-30.

Demmer, J. K., Huang, H., Wang. S., Demmer. U., Thauer, R. K. & Ermler U. (2015)
Insights into flavin-based electron bifurcation via the NADH- dependent reduced ferredoxin-NADP oxidoreductase structure. Journal of Biological Chemistry 290, 21985-21995.

Mock, J., Zheng, Y., Mueller, A. P., Ly, S., Tran, L., Segovia, S., Nagaraju, S., Köpke M., Dürre, P. & Thauer, R. K. (2015)
Energy conservation associated with ethanol formation from H2 and CO2 in Clostridium autoethanogenum involving electron bifurcation. Journal of Bacteriology 197, 2965-2980.

Lever, M. A., Rogers, K. L., Lloyd, K. G., Overmann. J., Schink, B., Thauer, R. K., Hoehler, T. M., and Jorgensen, B. B. (2015)
Life under Extreme Energy Limitation: A Synthesis of Laboratory- and Field-Based Investigations. FEMS Microbiology Reviews 39, 688-728.

2014

Mock, J. Wang, S., Huang, H., Kahnt, J. & Thauer, R. K. (2014)
Evidence for a hexameric methylenetetrahydrofolate reductase in Moorella thermoacetica. J. Bacteriol. 196, 3303-3314.

Zheng, Y., Kahnt, J., Kwon, I., Mackie, R. & Thauer, R. K. (2014)
Hydrogen formation and its regulation in Ruminococcus albus: Involvement of n electron-bifurcating [FeFe]-hydrogenase,on a non-electron-bifurcating [FeFe]-hydrogenase and of a putative H2 sensing [FeFe]-hydrogenase. J. Bacteriol. 196, 3840-3852.

2013

Scheller, S., Goenrich, M., Thauer, R. K. & Jaun, B. M. (2013)
Methyl-Coenzyme M Reductase from Methanogenic Archaea: Isotope Effects on Label Exchange and Ethane Formation with the Homologous Substrate Ethyl-Coenzyme M. J. Am. Chem. Soc. 135, 14985-14995.

Scheller, S., Goenrich, M., Thauer, R. K. & Jaun, B.M. (2013)
Methyl-Coenzyme M Reductase from Methanogenic Archaea: Isotope Effects on the Formation and Anaerobic Oxidation of Methane. J. Am. Chem. Soc. 134, 14975-14984.

Appel, A. M., Bercaw, J., E., Bocarsly, A. B., Dobbek, H., Dubois, D. L., Dupuis, M., Ferry, J. G., Fujita, E., Hille, R., Kenis, P. J., Kerfeld, C. A., Morris, R. H., Peden, C. H., Portis, A. R., Ragsdale, S. W., Rauchfuss, T. B., Reek, J. N., Seefeldt, L. C., Thauer, R. K. & Waldrop, G. L. (2013)
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation. Chem. Review 113 6621-6658.

Wang, S., Huang, H., Kahnt, J. & Thauer, R. K. (2013)
Clostridium acidurici Electron-bifurcating formate dehydrogenase. Appl. Environ. Microbiol. October 2013 79:6176-6179.

Wang, S., Huang, H., Kahnt, J., Mueller, A. P., Köpke, M. & Thauer, R. K. (2013)
NADP-specific Electron-bifurcating [FeFe]-hydrogenase in a Functional Complex with Formate Dehydrogenase in Clostridium autoethanogenum grown on CO. J. Bacteriol. 95:4373-4386.

Wang, S, Huang, H., Kahnt J & Thauer, R. K. (2013)
A reversible electron-bifurcating ferredoxin- and NAD-dependent [FeFe]-hydrogenase (HydABC) in Moorella thermoacetica. J. Bacteriol. 195(6):1267-75.

Buckel, W. & Thauer, R. K. (2013)
Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation. Biochim. Biophys. Acta 1827, 94-113.

2012

Poehlein A., Schmidt, S., Kaster, AK., Goenrich, M., Vollmers, J., Thürmer, A., Bertsch J., Schuchmann, K., Voigt, B., Hecker, M., Daniel, R., Thauer, R. K., Gottschalk, G., & Müller, V. (2012)
An Ancient Pathway Combining Carbon Dioxide Fixation with the Generation and Utilization of a Sodium Ion Gradient for ATP Synthesis. PLoS ONE 7(3): e33439. doi:10.1371/journal.pone.0033439.

Thauer, R. K. (2012)
The Wolfe cycle comes full cycle. PNAS 109(38) 15084-15085.

Huang, H., Wang, S., Moll, J. & Thauer, R. K. (2012)
Electron bifurcation involved in the energy metabolism of the acetogenic bacterium Moorella thermoacetica growing on glucose or H2 plus CO2. J. Bacteriol. 194: 3689-3699.

Shima, S., Krueger, M., Weinert, T. Demmer, U., Kahnt, J., Thauer, R. K. & Ermler, U. (2012)
Structure of a methyl-coenzyme M reductase from Black Sea mats that oxidize methane anaerobically. Nature 481, 98-101.

Friedrich, B., Schink, B. & Thauer, R. K. (2012)
Bioenergy- Chances and Limits. German National Academy of Sciences Leopoldina, pp 1-118 (www.leopoldina.org)

2011

Kaster, A.-K., Moll, J., Parey, K., & Thauer, R. K. (2011)
Coupling of ferredoxin- and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea. Proc. Natl. Acad. Sci. USA, 108, 2981-2986.

Kaster, A.-K., Goenrich, M., Seedorf,H., Liesegang, H., Wollherr, A., Gottschalk, G., & Thauer, R. K. (2011)
More than 200 genes required for methane formation from H2 and CO2 and energy conservation in Methanothermobacter marburgensis and M. thermautotrophicus. Archaea, Vol. 2011, Article ID 973848, 1-23 (doi:10.1155/2011/973848).

Gensheimer, M., Brandis-Heep, A., Agarwal S., Thauer, R. K. & Greiner, A. (2011)
Polymer/bacteria composite nanofiber nonwoven by electrospinning of living bacteria protected by hydrogel microparticles. Macromolecular Bioscience 11, 333-337.

Thauer, R. K. (2011)
Anaerobic oxidation of methane with sulfate: on the reversibility of the reactions that are catalyzed by enzymes also involved in methanogenesis from CO2 (2011) Current opinion in Microbiology 14 (DOI 10.1016/J.mib.2011.03.003).

Buckel, W. & Thauer, R. K. (2011)
Dual Role of S-Adenosylmethionine (SAM+) in the Methylation of sp2-Hybridized Electrophilic carbons. Angewandte Chemie DOI: 10.1002/anie.201105076

Thauer, R. K. (2011)
Hydrogenases and the global H2 cycle (2011) Eur. J. Inorg. Chem. 2011, 919-921.

Thauer, R. K. (2011)
A novel mechanism of energetic coupling in anaerobes. Environmental Microbiology Reports 3, 24-25.

Thauer R. K. (2011)
Buchbesprechung: Feodor Lynen Sei naiv und mach´ ein Experiment. Biographie des Münchener Biochemikers und Nobelpreisträgers von Heike Will. Angewandte Chemie Int. Ed., 50, 9537-9538.

Thauer, R. K. (2011)
Schwer zu widerlegen. Dem Mikrobiologen Wolfgang Buckel zum 70. Geburtstag. Marburger UniJournal 36, Seite 56l.

2010

Scheller, S., Goenrich, M., Boecher, R., Thauer, R. K. & Jaun, J. (2010)
The key nickel enzyme of methanogenesis catalyses anaerobic oxidation of methane Nature 465, 606-609.

Thauer, R. K. (2010)
Functionalization of methane in anaerobic microorganisms. Angewandte Chemie, 49, 6712-6713.

Scheller, S., Goenrich, M., Mayr, S. Thauer, R. K. & Jaun, B. (2010)
Intermediates in the catalytic cycle of methy-coenzyme M reductase: Isotope exchange is consistent with formation of a ?-alkane Ni complex. Angewandte Chemie, 49, 8112-8115.

Wang, S., Haiyan H., Moll, J., & Thauer, R. K. (2010)
NADP+ reduction with reduced ferredoxin and NADP+ reduction with NADH are coupled via an electron bifurcating enzyme complex in Clostridium kluyveri J. Bacteriol., 192,5115-5123.

Liesegang, H., Kaster, A.-K., Wiezer, A., Goenrich, M., Wollher, A., Seedorf, S., Gottschalk, G. &Thauer, R. K. (2010)
Complete Genome Sequence of Methanothermobacter marburgensis, a Methanoarchaeon Model Organism. J. Bacteriol., 192, 5850-5851.

Ebner, S., Jaun, B., Goenrich, M., Thauer, R. K. & Harmer, J. (2010)
Binding of coenzyme B induces a major conformational change in the active site of methyl-coenzyme M reductase J. Am. Chem. Soc. 132, 567-575.

Thauer, R. K., Kaster, A., Goenrich, M., Schick, M., Hiromoto, T. & Shima, S. (2010)
Hydrogenases from methanogenic archaea: structure and function, nickel regulation, and H2-storage. Ann. Rev. Biochemistry 79, 507-536.

2009

Jaun, B. and Thauer, R. K (2009)
Nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase (MCR). In Metal-carbon bonds in enzymes and cofactors, Vol.6 of Metal Ions in Life Sciences (Sigel, A., Sigel, H., Sigel, R.K.O., eds). John Wiley & Sons, Ltd, Chichester, UK, pp. 115-132.

Shima, S., Thauer, R. K. and Ermler, U. (2009)
Carbon monoxide as intrinsic ligands to iron in the active site of [Fe]-hydrogenase. In Metal-carbon bonds in enzymes and cofactors, Vol.6 of Metal Ionsin Life Sciences (Sigel, A., Sigel, H., Sigel, R.K.O., eds). John Wiley & Sons, Ltd, Chichester, UK, pp 19-240.

Hiromoto, T., Ataka, K., Pilak O., Vogt, S., Stagni, M.S., Meyer-Klaucke, W., Warkentin, E., Thauer, R. K., Shima, S., & Ermler, U. (2009)
The crystal structure of C176A mutated [Fe]-hydrogenase suggests an acyl-iron ligation in the active site iron complex. FEBS Letters 583, 585-590.

ter Meulen, V. & Thauer, R. K. (2009)
Celebrating Achim Trebst´s 80th birthday. Phoptosynthesis Research 100, 117-119.

Ceh, K., Demmer, U., Warkentin, E., Thauer, R. K., Shima, S. & Ermler, U. (2009)
Structural basis of the hydride transfer mechanism in F420-dependent methylene-tetrahydromethanopterin dehydrogenase. Biochemistry, 48, 10098-10108.

2008

Vogt, S., Lyon, E.J., Shima, S. and Thauer, R.K. (2008)
The exchange activities of [Fe] hydrogenase (iron-sulfur-cluster-free hydrogenase) from methanogenic archaea in comparison with the exchange activities of [FeFe] and [NiFe] hydrogenases. J Biol Inorg Chem. 13 (1), 97-106

Guo, Y., Wang, H., Xiao, Y., Vogt, S., Thauer, R.K., Shima, S., Volkers, P.I., Rauchfuss, T.B., Pelmenschikov, V., Case, D. A., Alp, E., Sturhahn, W., Yoda, Y. & Cramer, S.P. (2008)
Characteriazation of the Fe site in iron-sulfur cluster free hydrogenase (Hmd) and of a model compound via nuclear resonant vibrational spectroscopy (NRVS). Inorganic Chemistry 47, 3969-3977.

Thauer, R.K. & Shima, S. (2008)
Methane as fuel for anaerobic microorganisms. Annals of the New York Academy of Sciences. 1125, 158-170

Seedorf, H., Fricke, W.F., Veith, B., Brüggemann, H., Liesegang, H. Strittmatter, A., Miethke, M., Buckel, W., Hinderberger, J., Li, F., Hagemeier, C.H., Thauer, R. K. & Gottschalk, G. (2008)
The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features. PNAS,105 2128-2133

Li, F., Hinderberger, J., Seedorf, H., Zhang, J., Buckel, W. & Thauer, R. K. (2008)
Coupled ferredoxin and crotonyl coenzyme A (CoA) reduction with NADH catalyzed by the butyryl-CoA dehydrogenasee/Etf complex from Clostridium kluyveri. J. Bacteriol. 190, 843-50

Shima, S., Pilak O., Vogt, S., Schick, M., Stagni, M.S., Meyer-Klaucke, W., Warkentin, E., Thauer, R.K., & Ermler, U. (2008)
The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site. Science 321, 572-575

Harmer, J, Finazzo, C., Piskorski, R., Ebner, S., Duin, E.C., Goenrich, M., Thauer, R. K., Reiher, M., Schweiger, A., Hinderberger, D. & Jaun, B. (2008)
A nickel hydride complex in the active site of methyl-coenzyme M reductase: Implications for the catalytic cycle. J. Am. Chem. Soc., 130, 10907-10920

Mayr, S., Latkoczy Ch., Krüger, M., Günther, D., Shima, S., Thauer, R. K., Widdel, F. & Jaun, B. (2008)
Structure of an F430 variant from Archaea associated with anaerobic oxidation of methane. J. Am. Chem. Soc., 130, 10758-10767

Thauer, R. K., Kaster, A.K., Seedorf, H., Buckel, W., & Hedderich, R. (2008)
Methanogenic archaea: Ecologically relevant differences in energy conservation. Nature Reviews Microbiology 6, 579-591

Hinderberger, D., Ebner, S., Mayr, S., Jaun, B., Reiher, M., Goenrich, M., Thauer, R. K., & Harmer, J. (2008)
Coordination and binding geometry of methyl-coenzyme M in the red1m state of methyl-coenzyme M reductase. J. Biol. Inorg. Chem., 13, 1275-1289

Thauer, R. K. (2008)
Of methanotrophic and Methanogenic Archaea. In: Life Strategies of Microorganisms in the Environment and in Host Organisms (Amann R., Goebel, W., Reinhold-Hurek, B., Schink, B. and Widdel, F. eds). Nova Acta Leopoldina 96, 41-44 (see also pp. 9-10)

Thauer, R.K. (2008)
Biologiche Methanbildung: Eine erneuerbare Energiequelle von Bedeutung? In Die Zukunft der Energie (Gruss, P. und Schüth, F. Herausgeber) Verlag C. H. Beck, pp.119-137

Thauer, R. K. (2008)
Leopoldina als nationale Akademie der Wissenschaften BIOspektrum 14 (Heft 6), 567

Friedrich, B. & Thauer, R. K. (2008)
Molekularfunktion von Katalysatoren bei der Produktion von BioH2. Jahrbuch 2007 der Deutschen Akademie der Naturforscher Leopoldina, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, pp. 349-350

Thauer, R. (2007)
A fifth pathway of carbon fixation. Science 318, 1732-3

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