Publications of H. Link

Stecker, D.; Hoffmann, T.; Link, H.; Commichau, F. M.; Bremer, E.: L-Proline synthesis mutants of Bacillus subtilis overcome osmotic sensitivity by genetically adapting L-Arginine metabolism. Frontiers in Microbiology 13, 908304 (2022)

Gauttam, R.; Desiderato, C. K.; Radoš, D.; Link, H.; Seibold, G. M.; Eikmanns, B. J.: Metabolic Engineering of Corynebacterium glutamicum for Production of UDP-N-Acetylglucosamine. Front Bioeng Biotechnol 9, p. 748510 (2021)

Wang, C.-Y.; Lempp, M.; Farke, N.; Donati, S.; Glatter, T.; Link, H.: Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli. Nature Communications 12 (1), 4929 (2021)

Alseekh, S.; Aharoni, A.; Brotman, Y.; Contrepois, K.; D'Auria, J.; Ewald, J.; J, C. E.; Fraser, P. D.; Giavalisco, P.; Hall, R. D. et al.; Heinemann, M.; Link, H.; Luo, J.; Neumann, S.; Nielsen, J.; Perez de Souza, L.; Saito, K.; Sauer, U.; Schroeder, F. C.; Schuster, S.; Siuzdak, G.; Skirycz, A.; Sumner, L. W.; Snyder, M. P.; Tang, H.; Tohge, T.; Wang, Y.; Wen, W.; Wu, S.; Xu, G.; Zamboni, N.; Fernie, A. R.: Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices. Nature Methods 18 (7), pp. 747 - 756 (2021)

Schubert, C.; Winter, M.; Ebert-Jung, A.; Kierszniowska, S.; Nagel-Wolfrum, K.; Schramm, T.; Link, H.; Winter, S.; Unden, G.: C4-dicarboxylates and l-aspartate utilization by Escherichia coli K-12 in the mouse intestine: l-aspartate as a major substrate for fumarate respiration and as a nitrogen source. Environmental Microbiology 23 (5), pp. 2564 - 2577 (2021)

Donati, S.; Kuntz, M.; Pahl, V.; Farke, N.; Beuter, D.; Glatter, T.; Gomes-Filho, J. V.; Randau, L.; Wang, C.-Y.; Link, H.: Multi-omics analysis of CRISPRi-knockdowns identifies mechanisms that buffer decreases of enzymes in E. coli metabolism. Cell Systems 12 (1), pp. 56 - 67.E6 (2021)

Kochanowski, K.; Sander, T.; Link, H.; Chang, J.; Altschuler, S. J.; Wu, L. F.: Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes. CELL REPORTS 34 (3), 108647 (2021)

Diaz-Pascual, F.; Lempp, M.; Nosho, K.; Jeckel, H.; Jo, J. K.; Neuhaus, K.; Hartmann, R.; Jelli, E.; Hansen, M. F.; Price-Whelan, A. et al.; Dietrich, L. E.; Link, H.; Drescher, K.: Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies. eLife, 10:e70794 (2021)

Lempp, M.; Lubrano, P.; Bange, G.; Link, H.: Metabolism of non-growing bacteria. BIOLOGICAL CHEMISTRY 401 (12), pp. 1479 - 1485 (2020)

Schramm, T.; Lempp, M.; Beuter, D.; Sierra González, S.; Glatter, T.; Link, H.: High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli. METABOLIC ENGINEERING 60, pp. 14 - 24 (2020)

Ni, B.; Colin, R.; Link, H.; Endres, R. G.; Sourjik, V.: Growth-rate dependent resource investment in bacterial motile behavior quantitatively follows potential benefit of chemotaxis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (1), pp. 595 - 601 (2020)

Diaz-Pascual, F.; Hartmann, R.; Lempp, M.; Vidakovic, L.; Song, B.; Jeckel, H.; Thormann, K. M.; Yildiz, F. H.; Dunkel, J.; Link, H. et al.; Nadell, C. D.; Drescher, K.: Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function. NATURE MICROBIOLOGY 4 (12), pp. 2136 - + (2019)

Lempp, M.; Farke, N.; Kuntz, M.; Freibert, S. A.; Lill, R.; Link, H.: Systematic identification of metabolites controlling gene expression in E. coli. NATURE COMMUNICATIONS 10, 4463 (2019)

Boecker, S.; Zahoor, A.; Schramm, T.; Link, H.; Klamt, S.: Broadening the Scope of Enforced ATP Wasting as a Tool for Metabolic Engineering in Escherichia coli. SI 14 (9), 1800438 (2019)

Sander, T.; Wang, C.-Y.; Glatter, T.; Link, H.: CRISPRi-Based Downregulation of Transcriptional Feedback Improves Growth and Metabolism of Arginine Overproducing E. coli. ACS SYNTHETIC BIOLOGY 8 (9), pp. 1983 - 1990 (2019)

Laganenka, L.; Sander, T.; Lagonenko, A.; Chen, Y.; Link, H.; Sourjik, V.: Quorum Sensing and Metabolic State of the Host Control Lysogeny-Lysis Switch of Bacteriophage T1. MBIO 10 (5), e01884-19 (2019)

Sander, T.; Farke, N.; Diehl, C.; Kuntz, M.; Glatter, T.; Link, H.: Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E-coli by Enforcing Enzyme Overabundance. CELL SYSTEMS 8 (1), pp. 66 - + (2019)

Beuter, D.; Gomes, J.; Randau, L.; Diaz-Pascual, F.; Drescher, K.; Link, H.: Selective Enrichment of Slow-Growing Bacteria in a Metabolism-Wide CRISPRi Library with a TIMER Protein. ACS SYNTHETIC BIOLOGY 7 (12), pp. 2775 - 2782 (2018)

Buffing, M.; Link, H.; Christodoulou, D.; Sauer, U.: Capacity for instantaneous catabolism of preferred and non-preferred carbon sources in Escherichia coli and Bacillus subtilis. SCIENTIFIC REPORTS 8, 11760 (2018)

Christodoulou, D.; Link, H.; Fuhrer, T.; Kochanowski, K.; Gerosa, L.; Sauer, U.: Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress. CELL SYSTEMS 6 (5), p. 569 (2018)