Publications
Members of the Metabolomics Core Facility are only included in the authors list, if they contributed intellectually to a paper. In cases where we provide only standard analytical services, we kindly ask to be mentioned in the acknowledgement.
2024
Preprint
The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. (2024)
Journal Article
Emergence of fractal geometries in the evolution of a metabolic enzyme. Nature (2024)
Preprint
T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection through a phage-encoded decapping enzyme. (2024)
Preprint
Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community. (2024)
Journal Article
Isolation of an H2-dependent electron-bifurcating CO2-reducing megacomplex with MvhB polyferredoxin from Methanothermobacter marburgensis. The FEBS Journal (2024)
Preprint
Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans. (2024)
Journal Article
15 (3), e0331423 (2024)
Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus. mBio
Preprint
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans. (2024)
Journal Article
63 (6), e202316478 (2024)
Acyl and CO ligands in the [Fe]-hydrogenase cofactor scramble upon photolysis. Angewandte Chemie International Edition
Preprint
Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications. (2024)
2023
Journal Article
14 (1), 2682 (2023)
Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo. Nature Communications
Journal Article
14, 7597 (2023)
Identification of NAD-RNA species and ADPR-RNA decapping in Archaea. Nature Communications
Journal Article
12 (12), pp. 3521 - 3530 (2023)
Machine learning-supported enzyme engineering toward improved CO2-fixation of Glycolyl-CoA carboxylase. ACS Synthetic Biology
Journal Article
13 (18), pp. 12007 - 12020 (2023)
Identification of 2-Hydroxyacyl-CoA synthases with high acyloin condensation activity for orthogonal one-carbon bioconversion. ACS Catalysis
Journal Article
89 (7), e0023823 (2023)
Functional degeneracy in Paracoccus denitrificans Pd1222 is coordinated via RamB, which links expression of the Glyoxylate cycle to activity of the Ethylmalonyl-CoA pathway. Applied and Environmental Microbiology
Journal Article
9 (24), eadh4299 (2023)
Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO2 fixation. Science Advances
Journal Article
89 (6), e0011323 (2023)
Asparagine uptake: a cellular strategy of Methylocystis to combat severe salt stress. Applied and Environmental Microbiology
Journal Article
76, pp. 97 - 109 (2023)
Implementation of the β-hydroxyaspartate cycle increases growth performance of Pseudomonas putida on the PET monomer ethylene glycol. Metabolic Engineering
Journal Article
19 (2), pp. 168 - 175 (2023)
Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO2. Nature Chemical Biology
Preprint
An interdependent metabolic and genetic network shows emergent properties in vitro. (2023)
Journal Article
8 (12), pp. 2378 - 2391 (2023)
Simultaneous spatiotemporal transcriptomics and microscopy of Bacillus subtilis swarm development reveal cooperation across generations. Nature Microbiology
Journal Article
Novel design for a microfluidic-based platform for yeast replicative lifespan (RLS) analysis. Micro and Nano Engineering, 100199 (2023)
Preprint
NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections. (2023)
Journal Article
14 (1), 5818 (2023)
NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections. Nature Communications
Journal Article
7 (8), pp. 1745 - 1758 (2023)
ATP production from electricity with a new-to-nature electrobiological module. Joule
Journal Article
6 (12), pp. 1228 - 1240 (2023)
Construction and modular implementation of the THETA cycle for synthetic CO2 fixation. Nature Catalysis 2022
Journal Article
61 (50), e202213239 (2022)
The function of two radical-SAM enzymes, HcgA and HcgG, in the biosynthesis of the [Fe]-hydrogenase cofactor. Angewandte Chemie, International Edition in English
Journal Article
61 (51), e202206106 (2022)
Genome mining enabled by biosynthetic characterization uncovers a class of benzoxazolinate-containing natural products in diverse bacteria. Angewandte Chemie, International Edition in English
Journal Article
7 (5), e0040322 (2022)
Methylocystis sp. strain SC2 acclimatizes to increasing NH4+ levels by a precise rebalancing of enzymes and osmolyte composition. mSystems
Journal Article
13 (1), 3876 (2022)
A versatile active learning workflow for optimization of genetic and metabolic networks. Nature Communications
Journal Article
61 (22), e202200994 (2022)
In vitro biosynthesis of the [Fe]-hydrogenase cofactor verifies the proposed biosynthetic precursors. Angewandte Chemie, International Edition in English
Preprint
Identification of NAD-RNAs and ADPR-RNA decapping in the archaeal model organisms Sulfolobus acidocaldarius and Haloferax volcanii. (2022)
2021
Journal Article
11 (9), pp. 5396 - 5404 (2021)
Engineering a highly efficient carboligase for synthetic one-carbon metabolism. ACS Catalysis
Journal Article
60 (38), pp. 21056 - 21061 (2021)
Bioelectrocatalytic cofactor regeneration coupled to CO2 fixation in a redox-active hydrogel for stereoselective C-C bond formation. Angewandte Chemie, International Edition in English
Journal Article
60 (30), pp. 16420 - 16425 (2021)
A modular in vitro platform for the production of terpenes and polyketides from CO2. Angewandte Chemie, International Edition in English
Journal Article
118 (21), e2022307118 (2021)
A synthetic C4 shuttle via the beta-hydroxyaspartate cycle in C3 plants. Proceedings of the National Academy of Sciences of the United States of America 2020
Journal Article
61, pp. 181 - 196 (2020)
Hydrogen utilization by Methylocystis sp. strain SC2 expands the known metabolic versatility of type IIa methanotrophs. METABOLIC ENGINEERING
Journal Article
9, e54207 (2020)
Underground isoleucine biosynthesis pathways in E. coli. ELIFE
Patent
Microfluidic system for yeast aging analysis. WO 2020/043786 A1 (2020)
Journal Article
59 (14), pp. 5526 - 5530 (2020)
Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Journal Article
368 (6491), pp. 649 - + (2020)
Light-powered CO2 fixation in a chloroplast mimic with natural and synthetic parts. SI 2019
Journal Article
575 (7783), pp. 500 - + (2019)
Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle. NATURE
Journal Article
10, 2128 (2019)
Life After Secretion-Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions. FRONTIERS IN MICROBIOLOGY
Journal Article
58 (4), pp. 259 - 275 (2019)
3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L-Serine Synthesis. SI
Journal Article
21 (9), pp. 1426 - 1445 (2019)
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
Journal Article
142, pp. 50 - 58 (2019)
NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. BRAIN
Journal Article
116 (4), pp. 1241 - 1250 (2019)
Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2018
Journal Article
14 (12), p. 1127 (2018)
The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. NATURE CHEMICAL BIOLOGY
Journal Article
293 (44), pp. 17200 - 17207 (2018)
InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis. JOURNAL OF BIOLOGICAL CHEMISTRY
Journal Article
25 (7), p. 833 (2018)
Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis. CELL CHEMICAL BIOLOGY
Journal Article
285 (18), pp. 3376 - 3401 (2018)
NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS JOURNAL
Journal Article
18 (20), pp. 3172 - 3183 (2018)
Millifluidic culture improves human midbrain organoid vitality and differentiation. LAB ON A CHIP
Journal Article
4, 3 (2018)
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. NPJ AGING AND MECHANISMS OF DISEASE 2017
Journal Article
13 (4), pp. 363 - 365 (2017)
Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology
Journal Article
114 (16), pp. E3233 - E3242 (2017)
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Journal Article
7 (1), p. 42757 (2017)
In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment. Scientific Reports 2016
Journal Article
21 (4), 517 (2016)
A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters. Molecules
Journal Article
291 (12), pp. 6036 - 6058 (2016)
Saccharomyces cerevisiae Forms d-2-Hydroxyglutarate and Couples Its Degradation to d-Lactate Formation via a Cytosolic Transhydrogenase. JOURNAL OF BIOLOGICAL CHEMISTRY
Journal Article
354 (6314), pp. 900 - 904 (2016)
A synthetic pathway for the fixation of carbon dioxide in vitro. Science 2014
Journal Article
111 (2), pp. 359 - 371 (2014)
Beyond Growth Rate 0.6: What Drives Corynebacterium glutamicum to Higher Growth Rates in Defined Medium. BIOTECHNOLOGY AND BIOENGINEERING 2013
Patent
Vorrichtung und Verfahren zur Zellseparation. 102012009088 (2013)
Patent
Probeentnahmevorrichtung und Verfahren zur Entnahme einer Probe aus einem Bioreaktor. 102012003113 (2013)
Journal Article
110 (1), pp. 220 - 228 (2013)
Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. BIOTECHNOLOGY AND BIOENGINEERING
Book Chapter
Metabolomics in Biotechnology (Microbial Metabolomics). In: Metabolomics in Practice (2013)
2012
Journal Article
12 (11), pp. 2060 - 8 (2012)
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip
Journal Article
11, 122 (2012)
Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms. MICROBIAL CELL FACTORIES
Journal Article
2 (4), pp. 1012 - 30 (2012)
Error propagation analysis for quantitative intracellular metabolomics. Metabolites