Max Planck Institute for Terrestrial Microbiology

Publications

Members of the Metabolomics Core Facility are only included in the authors list, if they contributed intellectually to a paper. In cases where we provide only standard analytical services, we kindly ask to be mentioned in the acknowledgement.

2025

Journal Article

Inckemann, R. M.; Chotel, T.; Burgis, M.; Brinkmann, C. K.; Andreas, L.; Baumann, J.; Sharma, P.; Klose, M.; Barrett, J.; Ries, F. et al.; Paczia, N.; Glatter, T.; Mackinder, L. C. M.; Willmund, F.; Erb, T. J.: A modular high-throughput approach for advancing synthetic biology in the chloroplast of Chlamydomonas. Nature Plants (2025)

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Journal Article

Lago-Maciel, A.; Soares, J. C.; Zarzycki, J.; Buchanan, C. J.; Reif-Trauttmansdorff, T.; Schmidt, F. V.; Lometto, S.; Paczia, N.; Schuller, J. M.; Hansen, D. F. et al.; Heller, G. T.; Prinz, S.; Hochberg, G. K. A.; Pierik, A. J.; Rebelein, J. G.: Methylthio-alkane reductases use nitrogenase metalloclusters for carbon–sulfur bond cleavage. Nature Catalysis 8 (10), pp. 1089 - 1099 (2025)

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Preprint

Richter, P.; Merz, A.; Biboy, J.; Paczia, N.; Glatter, T.; Vollmer, W.; Thanbichler, M.: Peptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus. bioRxiv: the preprint server for biology, 2025.10.15.682734 (2025)

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Journal Article

Chen, H.; Malengo, G.; Wang, L.; Vogler, O.; Renner, M.; Glatter, T.; Paczia, N.; Unterweger, D.; Sourjik, V.; Diepold, A.: Coordination of virulence factors and lifestyle transition in Pseudomonas aeruginosa through single-cell analysis. Communications Biology 8 (1), 1236 (2025)

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Preprint

Gemmecker, Y.; Schall, I.; Seubert, A.; Paczia, N.; Heider, J.: An iron-dependent alcohol dehydrogenase is involved in ethanol metabolism of Aromatoleum aromaticum. Preprints.org (2025)

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Journal Article

Su, L.; Schmalhofer, M.; Grammbitter, G. L. C.; Paczia, N.; Glatter, T.; Groll, M.; Bode, H. B.: The isopropylstilbene precursor cinnamic acid inhibits anthraquinone pigment production by targeting AntI. Journal of the American Chemical Society 147 (24), pp. 20246 - 20250 (2025)

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Journal Article

Peters, L.; Drechsler, M.; Herrera, M. A.; Liu, J.; Pees, B.; Jarstorff, J.; Czerwinski, A.; Lubbock, F.; Angelidou, G.; Salzer, L. et al.; Moors, K. A.; Paczia, N.; Shi, Y.-M.; Schulenburg, H.; Kaleta, C.; Witting, M.; Liebeke, M.; Campopiano, D. J.; Bode, H. B.; Dierking, K.: Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans. Nature Communications 16 (1), 5151 (2025)

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Preprint

Rubinić, M.; Arias-Rojas, A.; Martinez, K. A.; Klimek, W.; Paczia, N.; Alagesan, K.; Duneau, D.; Iatsenko, I.: Sex differences in Drosophila intestinal metabolism contribute to sexually dimorphic infection outcome and alter gut pathogen virulence. bioRxiv: the preprint server for biology, 2025.05.22.655590 (2025)

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Journal Article

Günther, M.; Paczia, N.; Michels, S.; Fiebich, B. L.; Vogt, S.; Drewe, J.; Boonen, G.; Butterweck, V.; Culmsee, C.: Cimicifuga racemosa extract Ze 450 shifts macrophage immunometabolism and attenuates pro-inflammatory signaling. Biomedicine & Pharmacotherapy 188, 118130 (2025)

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Journal Article

Mies, U. S.; Zheng, H.; Meuser, K.; Radek, R.; Paczia, N.; Treitli, S. C.; Brune, A.: Comparative genomics of Elusimicrobiaceae (phylum Elusimicrobiota) and description of the isolates Elusimicrobium simillimum sp. nov., Elusimicrobium posterum sp. nov., and Parelusimicrobium proximum gen. nov. sp. nov. Systematic and Applied Microbiology 48 (3), 126606 (2025)

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Journal Article

Pérez-López, M. I.; Lubrano, P.; Angelidou, G.; Hoch, S.; Glatter, T.; Paczia, N.; Link, H.; Sourjik, V.: The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. PLOS Biology 23 (4), e3003077 (2025)

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Journal Article

Satanowski, A.; Marchal, D. G.; Perret, A.; Petit, J.-L.; Bouzon, M.; Döring, V.; Dubois, I.; He, H.; Smith, E. N.; Pellouin, V. et al.; Petri, H. M.; Rainaldi, V.; Nattermann, M.; Burgener, S.; Paczia, N.; Zarzycki, J.; Heinemann, M.; Bar-Even, A.; Erb, T. J.: Design and implementation of aerobic and ambient CO₂-reduction as an entry-point for enhanced carbon fixation. Nature Communications 16 (1), 3134 (2025)

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Journal Article

Zheng, L.; Li, W.; Christ, M.; Paczia, N.; Buckel, W.; Mais, C.-N.; Bolker, M.; Freitag, J.; Bange, G.: Mechanistic and structural insights into the itaconate-producing trans-aconitate decarboxylase Tad1. PNAS Nexus 4 (3), pgaf059 (2025)

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Journal Article

Orsi, E.; Schulz-Mirbach, H.; Cotton, C. A. R.; Satanowski, A.; Petri, H. M.; Arnold, S. L.; Grabarczyk, N.; Verbakel, R.; Jensen, K. S.; Donati, S. et al.; Paczia, N.; Glatter, T.; Küffner, A. M.; Chotel, T.; Schillmüller, F.; De Maria, A.; He, H.; Lindner, S. N.; Noor, E.; Bar-Even, A.; Erb, T. J.; Nikel, P. I.: Computation-aided designs enable developing auxotrophic metabolic sensors for wide-range glyoxylate and glycolate detection. Nature Communications 16 (1), 2168 (2025)

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2024

Journal Article

Schulz-Mirbach, H.; Wichmann, P.; Satanowski, A.; Meusel, H.; Wu, T.; Nattermann, M.; Burgener, S.; Paczia, N.; Bar-Even, A.; Erb, T. J.: New-to-nature CO₂-dependent acetyl-CoA assimilation enabled by an engineered B₁₂-dependent acyl-CoA mutase. Nature Communications 15 (1), 10235 (2024)

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Preprint

Henriques Pereira, D. P.; Xie, X.; Beyazay, T.; Paczia, N.; Subrati, Z.; Belz, J.; Volz, K.; Tüysüz, H.; Preiner, M.: The dinucleotide structure of NAD enables specific reduction on mineral surfaces. bioRxiv: the preprint server for biology, 2024.10.11.617347 (2024)

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Journal Article

He, H.; Gómez-Coronado, P. A.; Zarzycki, J.; Barthel, S.; Kahnt, J.; Claus, P.; Klein, M.; Klose, M.; de Crécy-Lagard, V.; Schindler, D. et al.; Paczia, N.; Glatter, T.; Erb, T. J.: Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies. Nature Communications 15 (1), 8898 (2024)

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Journal Article

Barthel, S.; Brenker, L.; Diehl, C.; Bohra, N.; Giaveri, S.; Paczia, N.; Erb, T. J.: in vitro transcription-based biosensing of glycolate for prototyping of a complex enzyme cascade. Synthetic Biology, ysae013 (2024)

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Journal Article

Pozhydaieva, N.; Billau, F. A.; Wolfram-Schauerte, M.; Ramírez Rojas, A. A.; Paczia, N.; Schindler, D.; Höfer, K.: Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications. PLOS Genetics 20 (9), e1011384 (2024)

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Preprint

Orsi, E.; Schulz-Mirbach, H.; Cotton, C. A.R.; Satanowski, A.; Petri, H.; Arnold, S. L.; Grabarczyk, N.; Verbakel, R.; Jensen, K. S.; Donati, S. et al.; Paczia, N.; Glatter, T.; Küffner, A. M.; Chotel, T.; Schillmueller, F.; De Maria, A.; He, H.; Lindner, S. N.; Noor, E.; Bar-Even, A.; Erb, T. J.; Nikel, P. I.: Expanding the biotechnological scope of metabolic sensors through computation-aided designs. bioRxiv: the preprint server for biology, 2024.08.23.609350 (2024)

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Journal Article

Scarinci, G.; Ariens, J.-L.; Angelidou, G.; Schmidt, S.; Glatter, T.; Paczia, N.; Sourjik, V.: Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community. Nature Communications 15 (1), 7238 (2024)

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Journal Article

Arias-Rojas, A.; Arifah, A. Q.; Angelidou, G.; Alshaar, B.; Schombel, U.; Forest, E.; Frahm, D.; Brinkmann, V.; Paczia, N.; Beisel, C. L. et al.; Gisch, N.; Iatsenko, I.: MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation. PLOS Pathogens 20 (8), e1012462 (2024)

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Journal Article

Schulz-Mirbach, H.; Krüsemann, J. L.; Andreadaki, T.; Nerlich, J. N.; Mavrothalassiti, E.; Boecker, S.; Schneider, P.; Weresow, M.; Abdelwahab, O.; Paczia, N. et al.; Dronsella, B.; Erb, T. J.; Bar-Even, A.; Klamt, S.; Lindner, S. N.: Engineering new-to-nature biochemical conversions by combining fermentative metabolism with respiratory modules. Nature Communications 15 (1), 6725 (2024)

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Journal Article

Schann, K.; Bakker, J.; Boinot, M.; Kuschel, P.; He, H.; Nattermann, M.; Paczia, N.; Erb, T. J.; Bar-Even, A.; Wenk, S.: Design, construction and optimization of formaldehyde growth biosensors with broad application in biotechnology. Microbial Biotechnology 17 (7), e14527 (2024)

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Journal Article

Giaveri, S.; Bohra, N.; Diehl, C.; Yang, H. Y.; Ballinger, M.; Paczia, N.; Glatter, T.; Erb, T. J.: Integrated translation and metabolism in a partially self-synthesizing biochemical network. Science 385 (6705), pp. 174 - 178 (2024)

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Journal Article

Schada v. Borzyskowsi, L.; Lucas, H.; Kremer, K.; Barthel, S.; Pommerenke, B.; Glatter, T.; Paczia, N.; Erhard, B.; Erb, T. J.: Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans. mBio 15 (8), e0152424 (2024)

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Preprint

Küffner, A. M.; Pommerenke, B.; Kley, L.; Ng, J. Z. Y.; Prinz, S.; Tinzl-Zechner, M.; Claus, P.; Paczia, N.; Zarzycki, J.; Hochberg, G. K. A. et al.; Erb, T. J.: Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins. bioRxiv: the preprint server for biology, 2024.06.28.601168 (2024)

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Journal Article

Sendker, F. L.; Lo, Y. K.; Heimerl, T.; Bohn, S.; Persson, L. J.; Mais, C.-N.; Sadowska, W.; Paczia, N.; Nußbaum, E.; del Carmen Sánchez Olmos, M. et al.; Forchhammer, K.; Schindler, D.; Erb, T. J.; Benesch, J. L. P.; Marklund, E. G.; Bange, G.; Schuller, J. M.; Hochberg, G. K. A.: Emergence of fractal geometries in the evolution of a metabolic enzyme. Nature 628 (8009), pp. 894 - 900 (2024)

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Preprint

Wolfram-Schauerte, M.; Moskalchuk, A.; Pozhydaieva, N.; Ramírez Rojas, A. A.; Schindler, D.; Kaiser, S.; Paczia, N.; Höfer, K.: T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection through a phage-encoded decapping enzyme. bioRxiv: the preprint server for biology, 2024.04.04.588121 (2024)

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Journal Article

Nomura, S.; Paczia, N.; Kahnt, J.; Shima, S.: Isolation of an H₂-dependent electron-bifurcating CO₂-reducing megacomplex with MvhB polyferredoxin from Methanothermobacter marburgensis. The FEBS Journal 291 (11), pp. 2449 - 2460 (2024)

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Journal Article

Addison, H. G.; Glatter, T.; Hochberg, G. K. A.; Rebelein, J. G.: Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus. mBio 15 (3), e0331423 (2024)

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Preprint

Peters, L.; Drechsler, M.; Pees, B.; Angelidou, G.; Salzer, L.; Moors, K. A.; Paczia, N.; Schulenburg, H.; Shi, Y.-M.; Kaleta, C. et al.; Witting, M.; Bode, H. B.; Dierking, K.: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans. bioRxiv: the preprint server for biology, 2024.02.06.579051 (2024)

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Journal Article

Schaupp, S.; Arriaza-Gallardo, F. J.; Paczia, N.; Ataka, K.; Shima, S.: Acyl and CO ligands in the [Fe]-hydrogenase cofactor scramble upon photolysis. Angewandte Chemie International Edition 63 (6), e202316478 (2024)

MPG.PuRe

2023

Journal Article

Nattermann, M.; Wenk, S.; Pfister, P.; He, H.; Lee, S.H.; Szymanski, W.; Guntermann, N.; Zhu, F.; Nickel, L.; Wallner, C. et al.; Zarzycki, J.; Paczia, N.; Gaißert, N.; Franciò, G.; Leitner, W.; Gonzalez, R.; Erb, T. J.: Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo. Nature Communications 14 (1), 2682 (2023)

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Journal Article

Gavriil, M.; Proietto, M.; Paczia, N.; Ginolhac, A.; Halder, R.; Valceschini, E.; Sauter, T.; Linster, C. L.; Sinkkonen, L.: 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition. Life science alliance 7 (2), e202302333 (2023)

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Preprint

Giaveri, S.; Bohra, N.; Diehl, C.; Ballinger, M.; Paczia, N.; Glatter, T.; Erb, T. J.: An interdependent metabolic and genetic network shows emergent properties in vitro. bioRxiv: the preprint server for biology, 2023.11.26.568713 (2023)

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Journal Article

Gomes-Filho, J. V.; Breuer, R.; Morales-Filloy, H. G.; Pozhydaieva, N.; Borst, A.; Paczia, N.; Soppa, J.; Höfer, K.; Jäschke, A.; Randau, L.: Identification of NAD-RNA species and ADPR-RNA decapping in Archaea. Nature Communications 14, 7597 (2023)

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Journal Article

Marchal, D. G.; Schulz, L.; Schuster, I.; Ivanovska, J.; Paczia, N.; Prinz, S.; Zarzycki, J.; Erb, T. J.: Machine learning-supported enzyme engineering toward improved CO₂-fixation of Glycolyl-CoA carboxylase. ACS Synthetic Biology 12 (12), pp. 3521 - 3530 (2023)

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Journal Article

Lee, S. H.; Chou, A.; Nattermann, M.; Zhu, F.; Clomburg, J. M.; Paczia, N.; Erb, T. J.; Gonzalez, R.: Identification of 2-Hydroxyacyl-CoA synthases with high acyloin condensation activity for orthogonal one-carbon bioconversion. ACS Catalysis 13 (18), pp. 12007 - 12020 (2023)

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Journal Article

Kremer, K.; Meier, D.; Theis, L.; Miller, S.; Rost-Nasshan, A.; Naing, Y. T.; Zarzycki, J.; Paczia, N.; Serrania, J.; Blumenkamp, P. et al.; Goesmann, A.; Becker, A.; Thanbichler, M.; Hochberg, G. K. A.; Carter, M. S.; Erb, T. J.: Functional degeneracy in Paracoccus denitrificans Pd1222 is coordinated via RamB, which links expression of the Glyoxylate cycle to activity of the Ethylmalonyl-CoA pathway. Applied and Environmental Microbiology 89 (7), e0023823 (2023)

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Journal Article

McLean, R.; Schwander, T.; Diehl, C.; Cortina, N. S.; Paczia, N.; Zarzycki, J.; Erb, T. J.: Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO₂ fixation. Science Advances 9 (24), eadh4299 (2023)

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Journal Article

Guo, K.; Glatter, T.; Paczia, N.; Liesack, W.: Asparagine uptake: a cellular strategy of Methylocystis to combat severe salt stress. Applied and Environmental Microbiology 89 (6), e0011323 (2023)

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Journal Article

Schada v. Borzyskowsi, L.; Schulz-Mirbach, H.; Troncoso Castellanos, M.; Severi, F.; Gomez Coronado, P. A.; Paczia, N.; Glatter, T.; Bar-Even, A.; Lindner, S. N.; Erb, T. J.: Implementation of the β-hydroxyaspartate cycle increases growth performance of Pseudomonas putida on the PET monomer ethylene glycol. Metabolic Engineering 76, pp. 97 - 109 (2023)

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Preprint

Gerlinger, P.; Angelidou, G.; Paczia, N.; Erb, T. J.: Ketosynthase engineering enhances activity and shifts specificity towards non-native extender units in type I linear polyketide synthase. bioRxiv: the preprint server for biology, 2023.02.16.528826 (2023)

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Journal Article

Diehl, C.; Gerlinger, P.; Paczia, N.; Erb, T. J.: Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO₂. Nature Chemical Biology 19 (2), pp. 168 - 175 (2023)

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Journal Article

Jeckel, H.; Nosho, K.; Neuhaus, K.; Hastewell, A. D.; Skinner, D. J.; Saha, D.; Netter, N.; Paczia, N.; Dunkel, J.; Drescher, K.: Simultaneous spatiotemporal transcriptomics and microscopy of Bacillus subtilis swarm development reveal cooperation across generations. Nature Microbiology 8 (12), pp. 2378 - 2391 (2023)

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Journal Article

Kaprou, G. D.; Andar, A.; Shah, P.; Linster, C. L.; Paczia, N.: Novel design for a microfluidic-based platform for yeast replicative lifespan (RLS) analysis. Micro and Nano Engineering, 100199 (2023)

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Journal Article

Klabunde, B.; Wesener, A.; Bertrams, W.; Beinborn, I.; Paczia, N.; Surmann, K.; Blankenburg, S.; Wilhelm, J.; Serrania, J.; Knoops, K. et al.; Elsayed, E. M.; Laakmann, K.; Jung, A. L.; Kirschbaum, A.; Hammerschmidt, S.; Alshaar, B.; Gisch, N.; Abu Mraheil, M.; Becker, A.; Völker, U.; Vollmeister, E.; Benedikter, B. J.; Schmeck, B.: NAD⁺ metabolism is a key modulator of bacterial respiratory epithelial infections. Nature Communications 14 (1), 5818 (2023)

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Journal Article

Luo, S.; Adam, D.; Giaveri, S.; Barthel, S.; Cestellos-Blanco, S.; Hege, D.; Paczia, N.; Castañeda-Losada, L.; Klose, M.; Arndt, F. et al.; Heider, J.; Erb, T. J.: ATP production from electricity with a new-to-nature electrobiological module. Joule 7 (8), pp. 1745 - 1758 (2023)

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Journal Article

Luo, S.; Diehl, C.; He, H.; Bae, Y.; Klose, M.; Claus, P.; Cortina, N. S.; Fernandez, C. A.; Schulz-Mirbach, H. A. M.; McLean, R. et al.; Ramírez Rojas, A. A.; Schindler, D.; Paczia, N.; Erb, T. J.: Construction and modular implementation of the THETA cycle for synthetic CO₂ fixation. Nature Catalysis 6 (12), pp. 1228 - 1240 (2023)

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2022

Journal Article

Arriaza-Gallardo, F. J.; Schaupp, S.; Zheng, Y.-C.; Abdul-Halim, M. F.; Hui-Jie, P.; Kahnt, J.; Angelidou, G.; Paczia, N.; Hu, X.; Costa, K. et al.; Shima, S.: The function of two radical-SAM enzymes, HcgA and HcgG, in the biosynthesis of the [Fe]-hydrogenase cofactor. Angewandte Chemie, International Edition in English 61 (50), e202213239 (2022)

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Journal Article

Shi, Y.-M.; Crames, J. J.; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Claus, P.; Paczia, N.; Ruckert, C. et al.; Kalinowski, J.; Bange, G.; Bode, H. B.: Genome mining enabled by biosynthetic characterization uncovers a class of benzoxazolinate-containing natural products in diverse bacteria. Angewandte Chemie, International Edition in English 61 (51), e202206106 (2022)

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Journal Article

Guo, K.; Hakobyan, A.; Glatter, T.; Paczia, N.; Liesack, W.: Methylocystis sp. strain SC2 acclimatizes to increasing NH₄⁺ levels by a precise rebalancing of enzymes and osmolyte composition. mSystems 7 (5), e0040322 (2022)

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publisher-version

Journal Article

Pandi, A.; Diehl, C.; Yazdizadeh Kharrazi, A.; Scholz, S. A.; Bobkova, E.; Faure, L.; Nattermann, M.; Adam, D.; Chapin, N.; Foroughijabbari, Y. et al.; Moritz, C.; Paczia, N.; Cortina, N. S.; Faulon, J. L.; Erb, T. J.: A versatile active learning workflow for optimization of genetic and metabolic networks. Nature Communications 13 (1), 3876 (2022)

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Journal Article

Danileviciute, E.; Zeng, N.; Capelle, C. M.; Paczia, N.; Gillespie, M. A.; Kurniawan, H.; Benzarti, M.; Merz, M. P.; Coowar, D.; Fritah, S. et al.; Weisenhorn, V.; Maria, D.; Gomez Giro, G.; Grusdat, M.; Baron, A.; Guerin, C.; Franchina, D. G.; Léonard, C.; Domingues, O.; Delhalle, S.; Wurst, W.; Turner, J. D.; Schwamborn, J. C.; Meiser, J.; Krüger, R.; Ranish, J.; Brenner, D.; Linster, C. L.; Balling, R.; Ollert, M.; Hefeng, F. Q.: PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing. Nature Metabolism 4 (5), pp. 589 - 607 (2022)

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Journal Article

Schaupp, S.; Arriaza Gallardo, F. J.; Pan, H. J.; Kahnt, J.; Angelidou, G.; Paczia, N.; Costa, K.; Hu, X.; Shima, S.: In vitro biosynthesis of the [Fe]-hydrogenase cofactor verifies the proposed biosynthetic precursors. Angewandte Chemie, International Edition in English 61 (22), e202200994 (2022)

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2021

Journal Article

Nattermann, M.; Burgener, S.; Pfister, P.; Chou, A.; Schulz, L.; Lee, S. H.; Paczia, N.; Zarzycki, J.; Gonzalez, R.; Erb, T. J.: Engineering a highly efficient carboligase for synthetic one-carbon metabolism. ACS Catalysis 11 (9), pp. 5396 - 5404 (2021)

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Journal Article

Castaneda-Losada, L.; Adam, D.; Paczia, N.; Buesen, D.; Steffler, F.; Sieber, V.; Erb, T. J.; Richter, M.; Plumere, N.: Bioelectrocatalytic cofactor regeneration coupled to CO₂ fixation in a redox-active hydrogel for stereoselective C-C bond formation. Angewandte Chemie, International Edition in English 60 (38), pp. 21056 - 21061 (2021)

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Journal Article

Sundaram, S.; Diehl, C.; Cortina, N. S.; Bamberger, J.; Paczia, N.; Erb, T. J.: A modular in vitro platform for the production of terpenes and polyketides from CO₂. Angewandte Chemie, International Edition in English 60 (30), pp. 16420 - 16425 (2021)

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Journal Article

Conrad, R.; Liu, P.; Claus, P.: Fractionation of stable carbon isotopes during acetate consumption by methanogenic and sulfidogenic microbial communities in rice paddy soils and lake sediments. Biogeosciences 18 (24), pp. 6533 - 6546 (2021)

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Journal Article

Roell, M.-S.; Schada von Borzykowski, L.; Westhoff, P.; Plett, A.; Paczia, N.; Claus, P.; Urte, S.; Erb, T. J.; Weber, A. P. M.: A synthetic C4 shuttle via the beta-hydroxyaspartate cycle in C3 plants. Proceedings of the National Academy of Sciences of the United States of America 118 (21), e2022307118 (2021)

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2020

Journal Article

Hakobyan, A.; Zhu, J.; Glatter, T.; Paczia, N.; Liesack, W.: Hydrogen utilization by Methylocystis sp. strain SC2 expands the known metabolic versatility of type IIa methanotrophs. METABOLIC ENGINEERING 61, pp. 181 - 196 (2020)

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Journal Article

Cotton, C. A. R.; Bernhardsgrütter, I.; He, H.; Burgener, S.; Schulz, L.; Paczia, N.; Dronsella, B.; Erban, A.; Toman, S.; Dempfle, M. et al.; De Maria, A.; Kopka, J.; Lindner, S. N.; Erb, T. J.; Bar-Even, A.: Underground isoleucine biosynthesis pathways in E. coli. ELIFE 9, e54207 (2020)

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Patent

Paczia, N.; Jung, P.; Shah, P.; Linster, C.; Dimaki, M.; Svendson, W.: Microfluidic system for yeast aging analysis. WO 2020/043786 A1 (2020)

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Journal Article

Burgener, S.; Cortina, N. S.; Erb, T. J.: Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 (14), pp. 5526 - 5530 (2020)

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Journal Article

Miller, T.; Beneyton, T.; Schwander, T.; Diehl, C.; Girault, M.; McLean, R.; Chotel, T.; Claus, P.; Cortina, N. S.; Baret, J.-C. et al.; Erb, T. J.: Light-powered CO₂ fixation in a chloroplast mimic with natural and synthetic parts. SI 368 (6491), pp. 649 - + (2020)

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2019

Journal Article

Schada v. Borzyskowsi, L.; Severi, F.; Krueger, K.; Hermann, L.; Gilardet, A.; Sippel, F.; Pommerenke, B.; Claus, P.; Cortina, N. S.; Glatter, T. et al.; Zauner, S.; Zarzycki, J.; Fuchs, B. M.; Bremer, E.; Maier, U. G.; Amann I, R.; Erb, T. J.: Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle. NATURE 575 (7783), pp. 500 - + (2019)

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Journal Article

Milne-Davies, B.; Helbig, C.; Wimmi, S.; Cheng, D. W. C.; Paczia, N.; Diepold, A.: Life After Secretion-Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions. FRONTIERS IN MICROBIOLOGY 10, 2128 (2019)

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Journal Article

Paczia, N.; Becker-Kettern, J.; Conrotte, J.-F.; Cifuente, J. O.; Guerin, M. E.; Linster, C. L.: 3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L-Serine Synthesis. SI 58 (4), pp. 259 - 275 (2019)

MPG.PuRe

Journal Article

Schymanski, E. L.; Baker, N. C.; Williams, A. J.; Singh, R. R.; Trezzi, J.-P.; Wilmes, P.; Kolber, P. L.; Kruger, R.; Paczia, N.; Linster, C. L. et al.; Balling, R.: Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS 21 (9), pp. 1426 - 1445 (2019)

MPG.PuRe

Journal Article

Van Bergen, N. J.; Guo, Y.; Rankin, J.; Paczia, N.; Becker-Kettern, J.; Kremer, L. S.; Pyle, A.; Conrotte, J.-F.; Ellaway, C.; Procopis, P. et al.; Prelog, K.; Homfray, T.; Baptista, J.; Baple, E.; Wakeling, M.; Massey, S.; Kay, D. P.; Shukla, A.; Girisha, K. M.; Lewis, L. E. S.; Santra, S.; Power, R.; Daubeney, P.; Montoya, J.; Ruiz-Pesini, E.; Kovacs-Nagy, R.; Pritsch, M.; Ahting, U.; Thorburn, D. R.; Prokisch, H.; Taylor, R. W.; Christodoulou, J.; Linster, C. L.; Ellard, S.; Hakonarson, H.: NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. BRAIN 142, pp. 50 - 58 (2019)

MPG.PuRe

Journal Article

Veiga-da-Cunha, M.; Chevalier, N.; Stephenne, X.; Defour, J.-P.; Paczia, N.; Ferster, A.; Achouri, Y.; Dewulf, J. P.; Linster, C. L.; Bommer, G. T. et al.; Van Schaftingen, E.: Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (4), pp. 1241 - 1250 (2019)

MPG.PuRe

2018

Journal Article

Berhardsgrütter, I.; Vögeli, B.; Wagner, T.; Peter, D.; Cortina, N. S.; Kahnt, J.; Bange, G.; Engilberge, S.; Girard, E.; Riobe, F. et al.; Maury, O.; Shima, S.; Zarzycki, J.; Erb, T. J.: The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. NATURE CHEMICAL BIOLOGY 14 (12), p. 1127 (2018)

MPG.PuRe

Journal Article

Vögeli, B.; Rosenthal, R.; Stoffel, G.; Wagner, T.; Kiefer, P.; Cortina, N. S.; Shima, S.; Erb, T. J.: InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis. JOURNAL OF BIOLOGICAL CHEMISTRY 293 (44), pp. 17200 - 17207 (2018)

MPG.PuRe

Journal Article

Vögeli, B.; Geyer, K.; Gerlinger, P.; Benkstein, S.; Cortina, N. S.; Erb, T. J.: Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis. CELL CHEMICAL BIOLOGY 25 (7), p. 833 (2018)

MPG.PuRe

Journal Article

Becker-Kettern, J.; Paczia, N.; Conrotte, J.-F.; Zhu, C.; Fiehn, O.; Jung, P. P.; Steinmetz, L. M.; Linster, C. L.: NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS JOURNAL 285 (18), pp. 3376 - 3401 (2018)

MPG.PuRe

Journal Article

Berger, E.; Magliaro, C.; Paczia, N.; Monzel, A. S.; Antony, P.; Linster, C. L.; Bolognin, S.; Ahluwalia, A.; Schwamborn, J. C.: Millifluidic culture improves human midbrain organoid vitality and differentiation. LAB ON A CHIP 18 (20), pp. 3172 - 3183 (2018)

MPG.PuRe

Journal Article

Jung, P. P.; Zhang, Z.; Paczia, N.; Jaeger, C.; Ignac, T.; May, P.; Linster, C. L.: Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. NPJ AGING AND MECHANISMS OF DISEASE 4, 3 (2018)

MPG.PuRe

2017

Journal Article

Gajewski, J.; Buelens, F.; Serdjukow, S.; Janssen, M.; Cortina, N.; Grubmueler, H.; Grininger, M.: Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology 13 (4), pp. 363 - 365 (2017)

MPG.PuRe

Journal Article

Peracchi, A.; Veiga-da-Cunha, M.; Kuhara, T.; Ellens, K. W.; Paczia, N.; Stroobant, V.; Seliga, A. K.; Marlaire, S.; Jaisson, S.; Bommer, G. T. et al.; Sun, J.; Huebner, K.; Linster, C. L.; Cooper, A. J. L.; van Schaftingen, E.: Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 (16), pp. E3233 - E3242 (2017)

MPG.PuRe

Journal Article

Zarzycki, J.; Sutter, M.; Cortina, N. S.; Erb, T. J.; Kerfeld, C. A.: In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment. Scientific Reports 7 (1), p. 42757 (2017)

MPG.PuRe

2016

Journal Article

Peter, D.; Vögeli, B.; Cortina, N. S.; Erb, T.J.: A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters. Molecules 21 (4), 517 (2016)

MPG.PuRe

Journal Article

Becker-Kettern, J.; Paczia, N.; Conrotte, J.-F.; Kay, D. P.; Guignard, C.; Jung, P. P.; Linster, C. L.: Saccharomyces cerevisiae Forms d-2-Hydroxyglutarate and Couples Its Degradation to d-Lactate Formation via a Cytosolic Transhydrogenase. JOURNAL OF BIOLOGICAL CHEMISTRY 291 (12), pp. 6036 - 6058 (2016)

MPG.PuRe

Journal Article

Schwander, T.; Schada v. Borzyskowsi, L.; Burgener, S.; Cortina, N. S.; Erb, T. J.: A synthetic pathway for the fixation of carbon dioxide in vitro. Science 354 (6314), pp. 900 - 904 (2016)

MPG.PuRe

2014

Journal Article

Unthan, S.; Gruenberger, A.; van Ooyen, J.; Gaetgens, J.; Heinrich, J.; Paczia, N.; Wiechert, W.; Kohlheyer, D.; Noack, S.: Beyond Growth Rate 0.6: What Drives Corynebacterium glutamicum to Higher Growth Rates in Defined Medium. BIOTECHNOLOGY AND BIOENGINEERING 111 (2), pp. 359 - 371 (2014)

MPG.PuRe

2013

Patent

Paczia, N.; Schramm, C.; Noack, S.: Vorrichtung und Verfahren zur Zellseparation. 102012009088 (2013)

MPG.PuRe

Patent

von Lieres, E.; Motyll, S.; Paczia, N.: Probeentnahmevorrichtung und Verfahren zur Entnahme einer Probe aus einem Bioreaktor. 102012003113 (2013)

MPG.PuRe

Journal Article

Gruenberger, A.; van Ooyen, J.; Paczia, N.; Rohe, P.; Schiendzielorz, G.; Eggeling, L.; Wiechert, W.; Kohlheyer, D.; Noack, S.: Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. BIOTECHNOLOGY AND BIOENGINEERING 110 (1), pp. 220 - 228 (2013)

MPG.PuRe

Book Chapter

Oldiges, M.; Noack, S.; Paczia, N.: Metabolomics in Biotechnology (Microbial Metabolomics). In: Metabolomics in Practice (2013)

MPG.PuRe

2012

Journal Article

Grünberger, A.; Paczia, N.; Probst, C.; Schendzielorz, G.; Eggeling, L.; Noack, S.; Wiechert, W.; Kohlheyer, D.: A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip 12 (11), pp. 2060 - 8 (2012)

MPG.PuRe

Journal Article

Paczia, N.; Nilgen, A.; Lehmann, T.; Gaetgens, J.; Wiechert, W.; Noack, S.: Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms. MICROBIAL CELL FACTORIES 11, 122 (2012)

MPG.PuRe

Journal Article

Tillack, J.; Paczia, N.; Noh, K.; Wiechert, W.; Noack, S.: Error propagation analysis for quantitative intracellular metabolomics. Metabolites 2 (4), pp. 1012 - 30 (2012)

MPG.PuRe