Emmy Noether Forschungsgruppe

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Dynamic Control of Metabolic Networks

Dr. Hannes Link

The group Dynamic Control of Metabolic Networks, headed by Dr. Hannes Link, investigates regulation of microbial metabolism. Our goal is to understand naturally evolved metabolic feedback and to implement synthetic control circuits in microbes like Escherichia coli. Specifically, we aim to coordinate overproduction of a chemical with metabolic resources of the production strain through engineering allosteric enzymes or interactions between metabolites and transcription factors. Our methods focus on metabolomics and metabolic flux profiling, and integration of these data with computational models.