Publications

Ernst, L.; Gätgens, C.; Rackow, B.; Pozhydaieva, N.; Gaaloul, E.; Krüger, A.; Seiffarth, J.; Bund, M.; Joisten-Rosenthal, V.; Kohlheyer, D. et al.; Usadel, B.; Harms, A.; Höfer, K.; Frunzke, J.: DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity. Proceedings of the National Academy of Sciences of the United States of America 123 (23), e2602073123 (2026)

Schön, M. E.; Schvarcz, C. R.; Malkewitz, S. V.; Hinner, F. C.; Koslová, A.; Mersdorf, U.; Schimm, F.; Rickert, S.; Pozhydaieva, N.; McBeain, K. et al.; Hackl, T.; Schneider, A. C.; Barenhoff, K.; Höfer, K.; Edwards, K. F.; Steward, G. F.; Fischer, M. G.: Strain-level diversity of giant viruses infecting chlorarachniophyte algae in the subtropical North Pacific. The ISME Journal 20 (1), wrag093 (2026)

Gimranov, E.; Oliveira, H.; Santos, S. B.; Weber, M.; Höfer, K.; Santos, C.; Moura, L.; Azeredo, J.: A genomically unique lytic bacteriophage infecting Pseudomonas syringae pv. actinidiae. Virology 619, 110864 (2026)

Kegel, N. B.; Yilmaz Demirel, N.; Glatter, T.; Höfer, K.; Kaufmann, A.; Bauer, S.: Proteins are a source of glycans found in preparations of glycoRNA. Experimental & Molecular Medicine (2025)

Keuthen, H.; Pozhydaieva, N.; Höfer, K.: Precise phage mutagenesis with NgTET-assisted CRISPR-Cas systems. Journal of Visualized Experiments (224), e69022 (2025)

Yilmaz Demirel, N.; Mumcuoglu, I.; Malengo, G.; Schmeck, B.; Jung, A. L.; Höfer, K.: Engineering site-specific nucleic acid-protein conjugates by utilizing a natural RNAylation reaction. bioRxiv: the preprint server for biology, 2025.07.11.664405 (2025)

Pozhydaieva, N.; Höfer, K.: Utilizing Golden Gate Assembly to streamline CRISPR-Cas/NgTET-based phage mutagenesis. In: Golden Gate Cloning. Methods in Molecular Biology, Vol. 2850 , pp. 329 - 343 (Ed. Schindler, D.). Humana, New York, NY. (2025)

Pozhydaieva, N.; Billau, F. A.; Wolfram-Schauerte, M.; Ramírez Rojas, A. A.; Paczia, N.; Schindler, D.; Höfer, K.: Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications. PLOS Genetics 20 (9), e1011384 (2024)

Yilmaz Demirel, N.; Weber, M.; Höfer, K.: Bridging the gap: RNAylation conjugates RNAs to proteins. Biochimica et Biophysica Acta: BBA 1871 (8), 119826 (2024)

Cortés-Martín, A.; Buttimer, C.; Pozhydaieva, N.; Hille, F.; Shareefdeen, H.; Bolocan, A. S.; Draper, L. A.; Shkoporov , A. N.; Franz , C. M. A. P.; Höfer, K. et al.; Ross, P. R.; Hill, C.: Isolation and characterization of Septuagintavirus; a novel clade of Escherichia coli phages within the subfamily Vequintavirinae. Microbiology Spectrum 12 (9), e00592-24 (2024)

Wolfram-Schauerte, M.; Moskalchuk, A.; Pozhydaieva, N.; Ramírez Rojas, A. A.; Schindler, D.; Kaiser, S.; Paczia, N.; Höfer, K.: T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection through a phage-encoded decapping enzyme. bioRxiv: the preprint server for biology, 2024.04.04.588121 (2024)

Pozhydaieva, N.; Wolfram-Schauerte, M.; Keuthen, H.; Höfer, K.: The enigmatic epitranscriptome of bacteriophages: putative RNA modifications in viral infections. Current Opinion in Microbiology 77, 102417 (2024)

Gomes-Filho, J. V.; Breuer, R.; Morales-Filloy, H. G.; Pozhydaieva, N.; Borst, A.; Paczia, N.; Soppa, J.; Höfer, K.; Jäschke, A.; Randau, L.: Identification of NAD-RNA species and ADPR-RNA decapping in Archaea. Nature Communications 14, 7597 (2023)

Lai, L. B.; Gopalan, V.; Jansson, M. D.; Chen, Q.; Zhang, X.; Wolfram-Schauerte, M.; Höfer, K.: Making nucleic acid structures and schematics. Trends in Biochemical Sciences 48 (8), pp. 655 - 658 (2023)

Wolfram-Schauerte, M.; Pozhydaieva, N.; Höfer, K.: Molekulare Schnappschüsse der Phageninfektion. (2023)

Gratani, F. L.; Englert, T.; Nashier, P.; Sass, P.; Czech, L.; Neumann, N.; Doello, S.; Mann, P.; Blobelt, R.; Alberti, S. et al.; Forchhammer, K.; Bange, G.; Höfer, K.; Macek, B.: E. coli toxin YjjJ (HipH) is a Ser/Thr protein kinase that impacts cell division, carbon metabolism, and ribosome assembly. mSystems 8 (1), e01043-22 (2023)

Wolfram-Schauerte, M.; Höfer, K.: NAD-capped RNAs - a redox cofactor meets RNA. Trends in Biochemical Sciences 48 (2), pp. 142 - 155 (2023)

Wolfram-Schauerte, M.; Pozhydaieva, N.; Grawenhoff, J.; Welp, L. M.; Silbern, I.; Wulf, A.; Billau, F. A.; Glatter, T.; Urlaub, H.; Jäschke, A. et al.; Höfer, K.: A viral ADP-ribosyltransferase attaches RNA chains to host proteins. Nature 620 (7976), pp. 1054 - 1062 (2023)

Yousefi, M. H.; Wagemans, J.; Shekarforoush, S. S.; Vallino, M.; Pozhydaieva, N.; Höfer, K.; Lavigne, R.; Hosseinzadeh, S.: Isolation and molecular characterization of the Salmonella typhimurium orphan phage Arash. BMC Microbiology 23, 297 (2023)

Wolfram-Schauerte, M.; Pozhydaieva, N.; Viering, M.; Glatter, T.; Höfer, K.: Integrated omics reveal time-resolved insights into T4 phage infection of E. coli on proteome and transcriptome levels. Viruses 14 (11), 2502 (2022)

Hinrichs, R.; Pozhydaieva, N.; Höfer, K.; Graumann, P. L.: Y-complex proteins show RNA-dependent binding events at the cell membrane and distinct single-molecule dynamics. Cells 11 (6), 933 (2022)

Schauerte, M.; Pozhydaieva, N.; Höfer, K.: Shaping the bacterial epitranscriptome-5'-terminal and internal RNA modifications. Advanced Biology 5 (8), e2100834 (2021)

Kolmar, T.; Büllmann, S. M.; Sarter, C.; Höfer, K.; Jäschke, A.: Development of High-Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches. Angewandte Chemie International Edition 60 (15), pp. 8164 - 8173 (2021)

Kolmar, T.; Bullmann, S. M.; Sarter, C.; Höfer, K.; Jäschke, A.: Development of High-Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches. Angew Chem Int Ed Engl 60 (15), pp. 8164 - 8173 (2021)

Möhler, M.; Höfer, K.; Jäschke, A.: Synthesis of 5'-Thiamine-Capped RNA. Molecules 25 (23) (2020)

Abele, F.; Höfer, K.; Bernhard, P.; Grawenhoff, J.; Seidel, M.; Krause, A.; Kopf, S.; Schröter, M.; Jäschke, A.: A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs. Biomolecules 10 (4) (2020)

Höfer, K.; Jäschke, A.: Epitranscriptomics: RNA Modifications in Bacteria and Archaea. Microbiol Spectr 6 (3) (2018)

Höfer, K.; Jäschke, A.: NAD-modifizierte RNA: Redox - biochemie trifft RNA-Prozessierung. (2018)

Winz, M. L.; Cahova, H.; Nübel, G.; Frindert, J.; Höfer, K.; Jäschke, A.: Capture and sequencing of NAD-capped RNA sequences with NAD captureSeq. Nat Protoc 12 (1), pp. 122 - 149 (2016)

Höfer, K.; Li, S.; Abele, F.; Frindert, J.; Schlotthauer, J.; Grawenhoff, J.; Du, J.; Patel, D. J.; Jäschke, A.: Structure and function of the bacterial decapping enzyme NudC. Nat Chem Biol 12 (9), pp. 730 - 4 (2016)

Höfer, K.; Jäschke, A.: Molecular biology: A surprise beginning for RNA. Nature 535 (7612), pp. 359 - 60 (2016)

Höfer, K.; Abele, F.; Schlotthauer, J.; Jäschke, A.: Synthesis of 5'-NAD-Capped RNA. Bioconjug Chem 27 (4), pp. 874 - 7 (2016)

Jäschke, A.; Höfer, K.; Nübel, G.; Frindert, J.: Cap-like structures in bacterial RNA and epitranscriptomic modification. Curr Opin Microbiol 30, pp. 44 - 49 (2016)

Cahova, H.; Winz, M. L.; Höfer, K.; Nübel, G.; Jäschke, A.: NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs. Nature 519 (7543), pp. 374 - 7 (2015)

Hayden, S. C.; Bryant, J. J.; Mackey, M. A.; Höfer, K.; Lindner, B. D.; Nguyen, V. P.; Jäschke, A.; Bunz, U. H.: Antimicrobial activity of water-soluble triazole phenazine clickamers against E. coli. Chemistry 20 (3), pp. 719 - 23 (2013)

Brameier, M.; Ibing, W.; Höfer, K.; Montag, J.; Stahl-Hennig, C.; Motzkus, D.: Mapping the small RNA content of simian immunodeficiency virions (SIV). PLoS One 8 (9), p. e75063 (2013)

Höfer, K.; Langejürgen, L. V.; Jäschke, A.: Universal aptamer-based real-time monitoring of enzymatic RNA synthesis. J Am Chem Soc 135 (37), pp. 13692 - 4 (2013)