Structure of mitochondrial complex I

SFB Mini Symposium

  • Date: Jun 20, 2016
  • Time: 13:15
  • Speaker: Prof. Dr. Volker Zickermann
  • Goethe-Universität Frankfurt, Institut für Biochemie II
  • Location: MPI for Terrestrial Microbiology
  • Room: Lecture hall
  • Host: SFB 987
  • Contact: Nelli.Melcher@sfb987.de
Mitochondrial complex I is the largest and most intricate enzyme of the respiratory chain. It comprises 14 central subunits that are conserved from bacteria to man and ~30 accessory subunits. The central subunits harbor the bioenergetic core functions and can be assigned to functional modules for NADH oxidation, ubiquinone reduction, and proton translocation. We have recently reported the X-ray structure of complex I from the aerobic yeast Yarrowia lipolytica at 3.6 to 3.9 Å resolution. The structure offers clues on the physiologically important active/deactive transition of complex I and on the catalytic cycle of redox-linked proton translocation.

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