Structure of mitochondrial complex I
SFB Mini Symposium
- Date: Jun 20, 2016
- Time: 01:15 PM (Local Time Germany)
- Speaker: Prof. Dr. Volker Zickermann
- Goethe-Universität Frankfurt, Institut für Biochemie II
- Location: MPI for Terrestrial Microbiology
- Room: Lecture hall
- Host: SFB 987
- Contact: Nelli.Melcher@sfb987.de
Mitochondrial complex I is the largest and most intricate enzyme of the respiratory chain. It comprises 14 central subunits that are conserved from bacteria to man and ~30 accessory subunits. The central subunits harbor the bioenergetic core functions and can be assigned to functional modules for NADH oxidation, ubiquinone reduction, and proton translocation. We have recently reported the X-ray structure of complex I from the aerobic yeast Yarrowia lipolytica at 3.6 to 3.9 Å resolution. The structure offers clues on the physiologically important active/deactive transition of complex I and on the catalytic cycle of redox-linked proton translocation.