Insights into the small RNA interactome of Sulfolobus acidocaldarius

Graduate Students Mini-Symposium

  • Date: Apr 18, 2016
  • Time: 13:50
  • Speaker: Michael Daume
  • MPI / RG Prokaryotic Small RNA Biology
  • Location: MPI for Terrestrial Microbiology
  • Room: Lecture hall
  • Host: Dr. Lennart Randau
  • Contact: lennart.randau@mpi-marburg.mpg.de
The regulation of cellular processes by small RNAs is in many cases mediated by their interaction with other RNA molecules, e.g. rRNA or mRNA, often facilitated by RNA-binding proteins. We identified the interaction partners of the RNA-binding proteins L7Ae and the three LSm proteins by RIP-Seq. The obtained RNA interactome datasets revealed several examples of RNA-regulated processes in Archaea. L7Ae was shown to autoregulate its translation by binding to a Kink-turn motif identified in the 5' UTR of its mRNA. The LSm1 and LSm2 proteins were found to interact with a sRNA involved in biofilm formation.
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