Graduate Students Mini Symposium I 2023
Microbiology Seminar Series
- Date: Jan 16, 2023
- Time: 01:00 PM (Local Time Germany)
- Location: MPI for Terrestrial Microbiology
- Room: Lecture Hall / Hybrid
- Host: IMPRS
- Contact: firstname.lastname@example.org
The exact time will be set in December
Luca Schulz - AG Erb
Robin Köhler - AG Murray
Sebastian Pöhl - AG Thanbichler
"A multi-protein network responsible for the establishment and fine-tuning of the curved cell shape of Rhodospirillum rubrum"
Bacteria come in many different shapes, which help them to move efficiently in the ecological niches they inhabit and thus ensure optimal fitness and survival. The mechanisms underlying morphogenesis in curved bacteria is a particularly interesting field of research, because in order to achieve a curved shape, the symmetry of the cells needs to be broken. Previous studies of curved model organisms, such as V. cholerae, H. pylori and C. crescentus, have revealed that bacteria have evolved a variety of fundamentally different shaping mechanisms. In our analysis of the morphogenetic pathway of the alphaproteobacterium Rhodospirillum rubrum, we have identified and characterized multiple proteins that are involved in the establishment and maintenance of its curved cell shape. Some of them, including spatially organized porins that position a conserved outer-membrane lipoprotein, are crucial for the establishment of cell curvature. Other proteins appear to be involved in fine-tuning the degree of curvature by exerting counteracting forces. Together, these factors form a novel and, in large part, conserved morphogenetic protein network that extends from the cytoplasm to the outer membrane and likely mediates the curved cell morphology in many spiral-shaped members of the family Rhodospirillaceae.