Graduate Students Mini Symposium VIII

Microbiology Seminar Series


16:00 h Michel Oklitschek, AG Sogaard Andersen
"Identification and characterization of SopA- a novel type IV pili-dependent motility regulator in Myxococcus xanthus"

M. xanthus moves across surfaces using type IV pili-(T4P). T4P undergo cycles of extension, adhesion, and retraction, thereby pulling cells forward. While the core components of the T4P machine are conserved, the regulators that control the function of this machine are more diverse. In M. xanthus, the small GTPase MglA interacts with the HEAT domain protein SgmX to stimulate T4P formation by unknown mechanism(s). To elucidate the molecular mechanism(s) of these two proteins, we used phylogenomics and in vivo experimentation. Here, we report the identification of SopA as a novel regulator of T4P formation.

16:30 h Mariana Sanchez-Londono, AG Randau

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