Integrative analysis and genome engineering of the near-minimal bacterium Mesoplasma florum

Microbiology Seminar Series

  • Date: Dec 6, 2021
  • Time: 16:00
  • Speaker: Prof. Sébastien Rodrigue
  • University of Sherbrooke, Quebec, Kanada
  • Location: Online
  • Host: Prof. Dr. Roland Lill
  • Contact: lill@staff.uni-marburg.de

The near-minimal bacterium Mesoplasma florum is an interesting model for synthetic genomics and systems biology due to its small genome (~800kb), fast growth rate as well as the possibility to perform whole-genome cloning and transplantation with this organism. We recently reported a detailed characterization of M. florum describing several physical and physiological parameters of this bacterium, including cell size, growth kinetics, and biomass composition of the cell. Using this experimental data as a foundation, we also developed a genome-scale model for M. florum and now perform genome engineering in this simple organism.


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