Transmission modes in two-component systems
Microbiology Seminar Series
- Date: Nov 1, 2021
- Time: 04:00 PM (Local Time Germany)
- Speaker: Felipe Trajtenberg, PhD
- Institut Pasteur de Montevideo, Uruguay
- Location: Online
- Host: Dr. Ilka Bischofs-Pfeifer
- Contact: ilka.bischofs@mpi-marburg.mpg.de
Cellular signaling systems transmit information over long distances using allosteric transitions and/or post-translational modifications. In two-component systems the sensor histidine kinase and response regulator are wired through phosphoryl-transfer reactions, using either a unidirectional or bi-directional transmission mode, allowing building richer regulatory networks. I will present our recent advances in understanding the molecular determinants that allow these bacterial signaling pathways to efficiently transmit information minimizing cellular energy waste.