Transmission modes in two-component systems

Microbiology Seminar Series

  • Date: Nov 1, 2021
  • Time: 04:00 PM (Local Time Germany)
  • Speaker: Felipe Trajtenberg, PhD
  • Institut Pasteur de Montevideo, Uruguay
  • Location: Online
  • Host: Dr. Ilka Bischofs-Pfeifer
  • Contact:

Cellular signaling systems transmit information over long distances using allosteric transitions and/or post-translational modifications. In two-component systems the sensor histidine kinase and response regulator are wired through phosphoryl-transfer reactions, using either a unidirectional or bi-directional transmission mode, allowing building richer regulatory networks. I will present our recent advances in understanding the molecular determinants that allow these bacterial signaling pathways to efficiently transmit information minimizing cellular energy waste.

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