Structural variation of type I-F CRISPR RNA guided DNA surveillance

Graduate Students Mini-Symposium

  • Date: Oct 23, 2017
  • Time: 13:15
  • Speaker: Patrick Pausch
  • LOEWE, Molecular Plasticity of Microbial Adaptation
  • Location: MPI for Terrestrial Microbiology
  • Room: Lecture hall
  • Host: Dr. Gert Bange
  • Contact:

CRISPR-Cas systems are adaptive immune systems against invading nucleic acids. Interestingly, although the CRISPR-Cas machinery that extends the CRISPR array upon novel threads is highly conserved, the surveillance and effector modules diversified substantially during the course of evolution. The ongoing ‘bacteria-virus’ arms race is supposed to be the main driving force of the continuing co-evolution and structural diversification of bacterial defense and viral CRISPR evasion mechanisms. Our comparative structural analysis of the type I-F variant (I-Fv) CRISPR Cascade complex with the evolutionary closely related type I-F Cascade sheds light on the astonishingly high modularity of CRISPR-Cas systems that might have emerged in response to the ‘bacteria-virus’ arms race.

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