Publications

2023
Journal Article
Abbood, N.; Effert, J.; Bozhüyük, K. A. J.; Bode, H. B.: Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases. ACS Synth. Biol. 12 (8), pp. 2432 - 2443 (2023)
Preprint
Abbood, N.; Effert, J.; Bozhüyük, K. A. J.; Bode, H. B.: Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases. (2023)
Book Chapter
Abbood, N.; Präve, L.; Bozhüyük, K. A. J.; Bode, H. B.: A Practical Guideline to Engineering Nonribosomal Peptide Synthetases. In: Non-Ribosomal Peptide Biosynthesis and Engineering. Methods in Molecular Biology,, Vol. 2670 (Eds. Burkart, M.; Ishikawa, F.). Humana, New York, NY, New York (2023)
Journal Article
Awori, R. M.; Waturu, C. N.; Pidot, S. J.; Amugune, N. O.; Bode, H. B.: Draft genomes, phylogenomic reconstruction and comparative genome analysis of three Xenorhabdus strains isolated from soil dwelling nematodes in Kenya. Access Microbiology 5 (5), acmi000531.v4 (2023)
Journal Article
Bode, E.; Assmann, D.; Happel, P.; Meyer, E.; Münch, K.; Roessel, N.; Bode, H. B.: easyPACId, a Simple Method for Induced Production, Isolation, Identification, and Testing of Natural Products from Proteobacteria. Bio-protocol 13 (13), p. e4709 (2023)
Journal Article
Cai, X.; Zhao, L.; Bode, H. B.: Engineering of Specific Single-Module Nonribosomal Peptide Synthetases of the RXP Type for the Production of Defined Peptides. ACS SYNTHETIC BIOLOGY 12 (1), pp. 203 - 212 (2023)
Journal Article
Huber, E. M.; Kreling, L.; Heinrich, A. K.; Dunnebacke, M.; Pothig, A.; Bode, H. B.; Groll, M.: A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments. Structure (London, England: 1993) 31 (5), 573-583.e5. (2023)
2022
Journal Article
Shi, Y.-M.; Crames, J. J.; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Claus, P.; Paczia, N.; Ruckert, C. et al.; Kalinowski, J.; Bange, G.; Bode, H. B.: Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria. Angew Chem Int Ed Engl (2022)
Journal Article
Muangpat, P.; Meesil, W.; Ngoenkam, J.; Teethaisong, Y.; Thummeepak, R.; Sitthisak, S.; Tandhavanant, S.; Chantratita, N.; Bode, H. B.; Vitta, A. et al.; Thanwisai, A.: Genome analysis of secondary metabolitebiosynthetic gene clusters of Photorhabdus akhurstii subsp. akhurstii and its antibacterial activity against antibiotic-resistant bacteria. PLoS One 17 (9), p. e0274956 (2022)
Journal Article
Muangpat, P.; Meesil, W.; Ngoenkam, J.; Teethaisong, Y.; Thummeepak, R.; Sitthisak, S.; Tandhavanant, S.; Chantratita, N.; Bode, H. B.; Vitta, A. et al.; Thanwisai, A.: Genome analysis of secondary metabolite-biosynthetic gene clusters of Photorhabdus akhurstii subsp. akhurstii and its antibacterial activity against antibiotic-resistant bacteria. PLOS ONE 17 (9), e0274956 (2022)
Journal Article
Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Bode, H. B.: Cleavage Off-Loading and Post-assembly-Line Conversions Yield Products with Unusual Termini during Biosynthesis. ACS Chem Biol 17 (8), pp. 2221 - 2228 (2022)
Journal Article
Ahmed, S.; Tafim Hossain Hrithik, M.; Chandra Roy, M.; Bode, H. B.; Kim, Y.: Phurealipids, produced by the entomopathogenic bacteria, Photorhabdus, mimic juvenile hormone to suppress insect immunity and immature development. J Invertebr Pathol 193, p. 107799 (2022)
Journal Article
Gulsen, S. H.; Tileklioglu, E.; Bode, E.; Cimen, H.; Ertabaklar, H.; Ulug, D.; Ertug, S.; Wenski, S. L.; Touray, M.; Hazir, C. et al.; Bilecenoglu, D. K.; Yildiz, I.; Bode, H. B.; Hazir, S.: Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach. Sci Rep 12 (1), p. 10779 (2022)
Journal Article
Abbood, N.; Vo, T. D.; Watzel, J.; Bozhueyuek, K. A. J.; Bode, H. B.: Type S Non-Ribosomal Peptide Synthetases for the Rapid Generation of Tailormade Peptide Libraries. CHEMISTRY-A EUROPEAN JOURNAL 28 (26), e202103963 (2022)
Journal Article
Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Ahmed, S.; Abebew, D.; Tobias, N. J.; Grun, P.; Crames, J. J.; Pöschel, L.; Kuttenlochner, W. et al.; Richter, C.; Herrmann, J.; Muller, R.; Thanwisai, A.; Pidot, S. J.; Stinear, T. P.; Groll, M.; Kim, Y.; Bode, H. B.: Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nat Chem (2022)
Journal Article
Abbood, N.; Bozhüyük, K. A. J.; Bode, H. B.: Synthetische Zipper für die Biosynthese neuer Naturstoffderivate. BIOspektrum 28 (4), pp. 446 - 449 (2022)
Journal Article
Abebew, D.; Sayedain, F.; Bode, E.; Bode, H. B.: Uncovering Nematicidal Natural Products from Xenorhabdus Bacteria. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)
Preprint
Bozhüyük, K. A. J.; Präve, L.; Kegler, C.; Kaiser, S.; Shi, Y.-N.; Kuttenlochner, W.; Schenk, L.; Mohiuddin, T. M.; Groll, M.; Hochberg, G. K. A. et al.; Bode, H. B.: Evolution Inspired Engineering of Megasynthetases. (2022)
Journal Article
Kavakli, S.; Grammbitter, G. L. C.; Bode, H. B.: Biosynthesis of the multifunctional isopropylstilbene in Photorhabdus laumondii involves cross-talk between specialized and primary metabolism. Tetrahedron 128, 133116 (2022)
Preprint
Kavakli, S.; Grammbitter, G. L. C.; Bode, H. B.: Biosynthesis of the Multifunctional Isopropylstilbene in <em>Photorhabdus laumondii</em> Involves Cross-Talk between Specialized and Primary Metabolism. (2022)
Preprint
Pandi, A.; Adam, D.; Zare, A.; Trinh, V. T.; Schaefer, S. L.; Wiegand, M.; Klabunde, B.; Bobkova, E.; Kushwaha, M.; Foroughijabbari, Y. et al.; Braun, P.; Spahn, C. K.; Preußer, C.; von Strandmann, E. P.; Bode, H. B.; Buttlar, H.; Bertrams, W.; Jung, A. L.; Abendroth, F.; Schmeck, B.; Hummer, G.; Vázquez, O.; Erb, T. J.: Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. (2022)
Journal Article
Sarawi, S.; Shi, Y.-N.; Lotz-Winter, H.; Reschke, K.; Bode, H. B.; Piepenbring, M.: Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. (Agaricales). PHYTOCHEMISTRY 195, 113069 (2022)
Journal Article
Zolfaghariyan, S.; Shakeri, A.; Asili, J.; Tarighi, S.; Grün, P.; Shi, Y.-M.; Bode, H. B.; Karimi, J.: Cyclic Depsipeptides and Linear Peptides With Cytotoxic and Antiphytopathogenic Activities From Symbiotic Bacteria of Xenorhabdus (Enterobacteriales: Morganellaceae) Genus. Annals of the Entomological Society of America (2022)
2021
Journal Article
Zhao, L.; Le Chapelain, C.; Brachmann, A. O.; Kaiser, M.; Groll, M.; Bode, H. B.: Activation, Structure, Biosynthesis and Bioactivity of Glidobactin-like Proteasome Inhibitors from Photorhabdus laumondii. CHEMBIOCHEM 22 (9), pp. 1582 - 1588 (2021)
Journal Article
Brachmann, A. O.; Probst, S. I.; Ruethi, J.; Dudko, D.; Bode, H. B.; Piel, J.: A Desaturase-Like Enzyme Catalyzes Oxazole Formation in Pseudomonas Indolyloxazole Alkaloids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 (16), pp. 8781 - 8785 (2021)
Journal Article
Watzel, J.; Sarawi, S.; Duchardt-Ferner, E.; Bode, H. B.; Woehnert, J.: NMR resonance assignments for a docking domain pair with an attached thiolation domain from the PAX peptide-producing NRPS from Xenorhabdus cabanillasii. BIOMOLECULAR NMR ASSIGNMENTS 15 (1), pp. 229 - 234 (2021)
Journal Article
Vo, T. D.; Spahn, C.; Heilemann, M.; Bode, H. B.: Microbial Cationic Peptides as a Natural Defense Mechanism against Insect Antimicrobial Peptides. ACS CHEMICAL BIOLOGY 16 (3), pp. 447 - 451 (2021)
Journal Article
Schorn, M. A.; Verhoeven, S.; Ridder, L.; Huber, F.; Acharya, D. D.; Aksenov, A. A.; Aleti, G.; Moghaddam, J. A.; Aron, A. T.; Aziz, S. et al.; Bauermeister, A.; Bauman, K. D.; Baunach, M.; Beemelmanns, C.; Beman, J. M.; Berlanga-Clavero, M. V.; Blacutt, A. A.; Bode, H. B.; Boullie, A.; Brejnrod, A.; Bugni, T. S.; Calteau, A.; Cao, L.; Carrion, V. J.; Castelo-Branco, R.; Chanana, S.; Chase, A. B.; Chevrette, M. G.; Costa-Lotufo, L. V.; Crawford, J. M.; Currie, C. R.; Cuypers, B.; Dang, T.; de Rond, T.; Demko, A. M.; Dittmann, E.; Du, C.; Drozd, C.; Dujardin, J. C.; Dutton, R. J.; Edlund, A.; Fewer, D. P.; Garg, N.; Gauglitz, J. M.; Gentry, E. C.; Gerwick, L.; Glukhov, E.; Gross, H.; Gugger, M.; Guillen Matus, D. G.; Helfrich, E. J. N.; Hempel, B. F.; Hur, J. S.; Iorio, M.; Jensen, P. R.; Kang, K. B.; Kaysser, L.; Kelleher, N. L.; Kim, C. S.; Kim, K. H.; Koester, I.; Konig, G. M.; Leao, T.; Lee, S. R.; Lee, Y. Y.; Li, X.; Little, J. C.; Maloney, K. N.; Mannle, D.; Martin, H. C.; McAvoy, A. C.; Metcalf, W. W.; Mohimani, H.; Molina-Santiago, C.; Moore, B. S.; Mullowney, M. W.; Muskat, M.; Nothias, L. F.; O'Neill, E. C.; Parkinson, E. I.; Petras, D.; Piel, J.; Pierce, E. C.; Pires, K.; Reher, R.; Romero, D.; Roper, M. C.; Rust, M.; Saad, H.; Saenz, C.; Sanchez, L. M.; Sorensen, S. J.; Sosio, M.; Sussmuth, R. D.; Sweeney, D.; Tahlan, K.; Thomson, R. J.; Tobias, N. J.; Trindade-Silva, A. E.; van Wezel, G. P.; Wang, M.; Weldon, K. C.; Zhang, F.; Ziemert, N.; Duncan, K. R.; Crusemann, M.; Rogers, S.; Dorrestein, P. C.; Medema, M. H.; van der Hooft, J. J. J.: A community resource for paired genomic and metabolomic data mining. Nat Chem Biol 17 (4), pp. 363 - 368 (2021)
Journal Article
Behsaz, B.; Bode, E.; Gurevich, A.; Shi, Y.-N.; Grundmann, F.; Acharya, D.; Caraballo-Rodriguez, A. M.; Bouslimani, A.; Panitchpakdi, M.; Linck, A. et al.; Guan, C.; Oh, J.; Dorrestein, P. C.; Bode, H. B.; Pevzner, P. A.; Mohimani, H.: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery (vol 12, 3225, 2021). NATURE COMMUNICATIONS 12 (1), 4318 (2021)
Journal Article
Behsaz, B.; Bode, E.; Gurevich, A.; Shi, Y.-N.; Grundmann, F.; Acharya, D.; Caraballo-Rodriguez, A. M.; Bouslimani, A.; Panitchpakdi, M.; Linck, A. et al.; Guan, C.; Oh, J.; Dorrestein, P. C.; Bode, H. B.; Pevzner, P. A.; Mohimani, H.: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. NATURE COMMUNICATIONS 12 (1), 3225 (2021)
Journal Article
Bozhüyük, K. A. J.; Watzel, J.; Abbood, N.; Bode, H. B.: Synthetic Zippers as an Enabling Tool for Engineering of Non-Ribosomal Peptide Synthetases**. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 (32), pp. 17531 - 17538 (2021)
Journal Article
Cimen, H.; Touray, M.; Gulsen, S. H.; Erincik, O.; Wenski, S. L.; Bode, H. B.; Shapiro-Ilan, D.; Hazir, S.: Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 105 (13), pp. 5517 - 5528 (2021)
Journal Article
Erkoc, P.; Schmitt, M.; Ingelfinger, R.; Bischoff-Kont, I.; Kopp, L.; Bode, H. B.; Schiffmann, S.; Fuerst, R.: Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells. BIOMEDICINE & PHARMACOTHERAPY 140, 111765 (2021)
Journal Article
Incedayi, G.; Cimen, H.; Ulug, D.; Touray, M.; Bode, E.; Bode, H. B.; Yaylagul, E. O.; Hazir, S.; Cakmak, I.: Relative potency of a novel acaricidal compound from Xenorhabdus, a bacterial genus mutualistically associated with entomopathogenic nematodes. SCIENTIFIC REPORTS 11 (1), 11253 (2021)
Journal Article
Machado, R. A. R.; Muller, A.; Ghazal, S. M.; Thanwisai, A.; Pages, S.; Bode, H. B.; Hussein, M. A.; Khalil, K. M.; Tisa, L. S.: Photorhabdus heterorhabditis subsp. aluminescens subsp. nov., Photorhabdus heterorhabditis subsp. heterorhabditis subsp. nov., Photorhabdus australis subsp. thailandensis subsp. nov., Photorhabdus australis subsp. australis subsp. nov., and Photorhabdus aegyptia sp. nov. isolated from Heterorhabditis entomopathogenic nematodes. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY 71 (1), 004610 (2021)
Journal Article
Maher, A. M. D.; Asaiyah, M.; Quinn, S.; Burke, R.; Wolff, H.; Bode, H. B.; Griffin, C. T.: Competition and Co-existence of TwoPhotorhabdusSymbionts with a Nematode Host. MICROBIAL ECOLOGY 81 (1), pp. 223 - 239 (2021)
Journal Article
Miethke, M.; Pieroni, M.; Weber, T.; Bronstrup, M.; Hammann, P.; Halby, L.; Arimondo, P. B.; Glaser, P.; Aigle, B.; Bode, H. B. et al.; Moreira, R.; Li, Y.; Luzhetskyy, A.; Medema, M. H.; Pernodet, J.-L.; Stadler, M.; Tormo, J. R.; Genilloud, O.; Truman, A. W.; Weissman, K. J.; Takano, E.; Sabatini, S.; Stegmann, E.; Brotz-Oesterhelt, H.; Wohlleben, W.; Seemann, M.; Empting, M.; Hirsch, A. K. H.; Loretz, B.; Lehr, C.-M.; Titz, A.; Herrmann, J.; Jaeger, T.; Alt, S.; Hesterkamp, T.; Winterhalter, M.; Schiefer, A.; Pfarr, K.; Hoerauf, A.; Graz, H.; Graz, M.; Lindvall, M.; Ramurthy, S.; Karlen, A.; van Dongen, M.; Petkovic, H.; Keller, A.; Peyrane, F.; Donadio, S.; Fraisse, L.; Piddock, L. J. V.; Gilbert, I. H.; Moser, H. E.; Muller, R.: Towards the sustainable discovery and development of new antibiotics. NATURE REVIEWS CHEMISTRY 5 (10), pp. 726 - 749 (2021)
Journal Article
Murray, A. E.; Freudenstein, J.; Gribaldo, S.; Hatzenpichler, R.; Hugenholtz, P.; Kampfer, P.; Konstantinidis, K. T.; Lane, C. E.; Papke, R. T.; Parks, D. H. et al.; Rossello-Mora, R.; Stott, M. B.; Sutcliffe, I. C.; Thrash, J. C.; Venter, S. N.; Whitman, W. B.; Acinas, S. G.; Amann, R. I.; Anantharaman, K.; Armengaud, J.; Baker, B. J.; Barco, R. A.; Bode, H. B.; Boyd, E. S.; Brady, C. L.; Carini, P.; Chain, P. S. G.; Colman, D. R.; DeAngelis, K. M.; de los Rios, M. A.; de los Santos, P.; Dunlap, C. A.; Eisen, J. A.; Emerson, D.; Ettema, T. J. G.; Eveillard, D.; Girguis, P. R.; Hentschel, U.; Hollibaugh, J. T.; Hug, L. A.; Inskeep, W. P.; Ivanova, E. P.; Klenk, H.-P.; Li, W.-J.; Lloyd, K. G.; Loffler, F. E.; Makhalanyane, T. P.; Moser, D. P.; Nunoura, T.; Palmer, M.; Parro, V.; Pedros-Alio, C.; Probst, A. J.; Smits, T. H. M.; Steen, A. D.; Steenkamp, E. T.; Spang, A.; Stewart, F. J.; Tiedje, J. M.; Vandamme, P.; Wagner, M.; Wang, F.-P.; Yarza, P.; Hedlund, B. P.; Reysenbach, A.-L.: Roadmap for naming uncultivated Archaea and Bacteria (vol 5, pg 987, 2020). NATURE MICROBIOLOGY 6 (1), p. 136 - 136 (2021)
Journal Article
Reyes-Fernandez, E. Z.; Shi, Y.-M.; Gruen, P.; Bode, H. B.; Boelker, M.: An Unconventional Melanin Biosynthesis Pathway in Ustilago maydis. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 87 (3), e01510-20 (2021)
Journal Article
Sayedain, F. S.; Ahmadzadeh, M.; Fattah-Hosseini, S.; Bode, H. B.: Soil application of entomopathogenic nematodes suppresses the root-knot nematodeMeloidogyne javanicain cucumber. JOURNAL OF PLANT DISEASES AND PROTECTION 128 (1), pp. 215 - 223 (2021)
Journal Article
Singh, G.; Calchera, A.; Schulz, M.; Drechsler, M.; Bode, H. B.; Schmitt, I.; Dal Grande, F.: Climate-specific biosynthetic gene clusters in populations of a lichen-forming fungus. ENVIRONMENTAL MICROBIOLOGY 23 (8), pp. 4260 - 4275 (2021)
Journal Article
Watzel, J.; Duchardt-Ferner, E.; Sarawi, S.; Bode, H. B.; Wohnert, J.: Cooperation between a T Domain and a Minimal C-Terminal Docking Domain to Enable Specific Assembly in a Multiprotein NRPS. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Journal Article
Wenski, S. L.; Berghaus, N.; Keller, N.; Bode, H. B.: Structure and biosynthesis of deoxy-polyamine in Xenorhabdus bovienii. SI 48 (3-4), kuab006 (2021)
2020
Journal Article
Neubacher, N.; Tobias, N. J.; Huber, M.; Cai, X.; Glatter, T.; Pidot, S. J.; Stinear, T. P.; Lutticke, A. L.; Papenfort, K.; Bode, H. B.: Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat Microbiol 5 (12), pp. 1481 - 1489 (2020)
Journal Article
Braeuer, A.; Zhou, Q.; Grammbitter, G. L. C.; Schmalhofer, M.; Ruehl, M.; Kaila I, V. R.; Bode, H. B.; Groll, M.: Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis. NATURE CHEMISTRY 12 (8) (2020)
Journal Article
Kegler, C.; Bode, H. B.: Artificial Splitting of a Non-Ribosomal Peptide Synthetase by Inserting Natural Docking Domains. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 (32), pp. 13463 - 13467 (2020)
Journal Article
Machado, R. A. R.; Thoenen, L.; Arce, C. C. M.; Theepan, V.; Prada, F.; Wuethrich, D.; Robert, C. A. M.; Vogiatzaki, E.; Shi, Y.-M.; Schaeren, O. P. et al.; Notter, M.; Bruggmann, R.; Hapfelmeier, S.; Bode, H. B.; Erb, M.: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm (Feb, 10.1038/s41587-020-0419-1, 2020). NATURE BIOTECHNOLOGY 38 (5), p. 649 - 649 (2020)
Journal Article
Machado, R. A. R.; Thonen, L.; Arce, C. C. M.; Theepan, V.; Prada, F.; Wuthrich, D.; Robert, C. A. M.; Vogiatzaki, E.; Shi, Y.-M.; Schaeren, O. P. et al.; Notter, M.; Bruggmann, R.; Hapfelmeier, S.; Bode, H. B.; Erb, M.: Engineering bacterial symbionts of nematodes improves biocontrol potential of the western corn rootworm. NATURE BIOTECHNOLOGY 38 (5) (2020)
Journal Article
Murray, A. E.; Freudenstein, J.; Gribaldo, S.; Hatzenpichler, R.; Hugenholtz, P.; Kaempfer, P.; Konstantinidis, K. T.; Lane, C. E.; Papke, R. T.; Parks, D. H. et al.; Rossello-Mora, R.; Stott, M. B.; Sutcliffe, I. C.; Thrash, J. C.; Venter, S. N.; Whitman, W. B.; Acinas, S. G.; Amann I, R.; Anantharaman, K.; Armengaud, J.; Baker, B. J.; Barco, R. A.; Bode, H. B.; Boyd, E. S.; Brady, C. L.; Carini, P.; Chain, P. S. G.; Colman, D. R.; DeAngelis, K. M.; de los Rios, M. A.; Estrada-de los Santos, P.; Dunlap, C. A.; Eisen, J. A.; Emerson, D.; Ettema, T. J. G.; Eveillard, D.; Girguis, P. R.; Hentschel, U.; Hollibaugh, J. T.; Hug, L. A.; Inskeep, W. P.; Ivanova, E. P.; Klenk, H.-P.; Li, W.-J.; Lloyd, K. G.; Lffler, F. E.; Makhalanyane, T. P.; Moser, D. P.; Nunoura, T.; Palmer, M.; Parro, V.; Pedros-Alio, C.; Probst, A. J.; Smits, T. H. M.; Steen, A. D.; Steenkamp, E. T.; Spang, A.; Stewart, F. J.; Tiedje, J. M.; Vandamme, P.; Wagner, M.; Wang, F.-P.; Hedlund, B. P.; Reysenbach, A.-L.: Roadmap for naming uncultivated Archaea and Bacteria. NATURE MICROBIOLOGY 5 (8), pp. 987 - 994 (2020)
Journal Article
Siebels, I.; Nowak, S.; Heil, C. S.; Tufar, P.; Cortina, N. S.; Bode, H. B.; Grininger, M.: Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. ACS SYNTHETIC BIOLOGY 9 (9), pp. 2418 - 2426 (2020)
Journal Article
Tietze, A.; Shi, Y.-N.; Kronenwerth, M.; Bode, H. B.: Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains. CHEMBIOCHEM 21 (19), pp. 2750 - 2754 (2020)
Journal Article
Tobias, N. J.; Brehm, J.; Kresovic, D.; Brameyer, S.; Bode, H. B.; Heermann, R.: New Vocabulary for Bacterial Communication. CHEMBIOCHEM 21 (6), pp. 759 - 768 (2020)
Journal Article
Watzel, J.; Hacker, C.; Duchardt-Ferner, E.; Bode, H. B.; Woehnert, J.: A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from Xenorhabdus bovienii. ACS CHEMICAL BIOLOGY 15 (4), pp. 982 - 989 (2020)
Journal Article
Wenskil, S. L.; Cimen, H.; Berghaus, N.; Fuchs, S. W.; Hazir, S.; Bode, H. B.: Fabclavine diversity in Xenorhabdus bacteria. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 16, pp. 956 - 965 (2020)
Journal Article
Zhao, L.; Vo, T. D.; Kaiser, M.; Bode, H. B.: Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity. CHEMBIOCHEM 21 (9), pp. 1288 - 1292 (2020)
2019
Journal Article
Reinheimer, C.; Buttner, D.; Proschak, E.; Bode, H. B.; Kempf, V. A. J.; Wichelhaus, T. A.: Anti-tubercular activity of a natural stilbene and its synthetic derivatives. GMS Infect Dis 6, p. Doc01 (2019)
Journal Article
Armaleo, D.; Mueller, O.; Lutzoni, F.; Andresson, O. S.; Blanc, G.; Bode, H. B.; Collart, F. R.; Dal Grande, F.; Dietrich, F.; Grigoriev, I. V. et al.; Joneson, S.; Kuo, A.; Larsen, P. E.; Logsdon Jr., J. M.; Lopez, D.; Martin, F.; May, S. P.; McDonald, T. R.; Merchant, S. S.; Miao, V.; Morin, E.; Oono, R.; Pellegrini, M.; Rubinstein, N.; Sanchez-Puerta, M. V.; Savelkoul, E.; Schmitt, I.; Slot, J. C.; Soanes, D.; Szovenyi, P.; Talbot, N. J.; Veneault-Fourrey, C.; Xavier, B. B.: The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata. BMC GENOMICS 20, 605 (2019)
Journal Article
Berry, D.; Mace, W.; Grage, K.; Wesche, F.; Gore, S.; Schardl, C. L.; Young, C. A.; Dijkwel, P. P.; Leuchtmann, A.; Bode, H. B. et al.; Scott, B.: Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (51), pp. 25614 - 25623 (2019)
Journal Article
Bode, E.; Heinrich, A. K.; Hirschmann, M.; Abebew, D.; Shi, Y.-N.; Tien Vo, D.; Wesche, F.; Shi, Y.-M.; Gruen, P.; Simonyi, S. et al.; Keller, N.; Engel, Y.; Wenski, S.; Bennet, R.; Beyer, S.; Bischoff, I.; Buaya, A.; Brandt, S.; Cakmak, I.; Cimen, H.; Eckstein, S.; Frank, D.; Fuerst, R.; Gand, M.; Geisslinger, G.; Hazir, S.; Henke, M.; Heermann, R.; Lecaudey, V.; Schaefer, W.; Schiffmann, S.; Schueffler, A.; Schwenk, R.; Skaljac, M.; Thines, E.; Thines, M.; Ulshoefer, T.; Vilcinskas, A.; Wichelhaus, T. A.; Bode, H. B.: Promoter Activation in Delta hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (52), pp. 18957 - 18963 (2019)
Journal Article
Bozhueyuek, K. A. J.; Linck, A.; Tietze, A.; Kranz, J.; Wesche, F.; Nowak, S.; Fleischhacker, F.; Shi, Y.-N.; Gruen, P.; Bode, H. B.: Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains. NATURE CHEMISTRY 11 (7), pp. 653 - 661 (2019)
Journal Article
Cai, X.; Zhao, L.; Bode, H. B.: Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides. ORGANIC LETTERS 21 (7), pp. 2116 - 2120 (2019)
Journal Article
Calchera, A.; Dal Grande, F.; Bode, H. B.; Schmitt, I.: Biosynthetic Gene Content of the "Perfume Lichens' Evernia prunastri and Pseudevernia furfuracea. MOLECULES 24 (1), 203 (2019)
Journal Article
Drummond, L.; Kschowak, M. J.; Breitenbach, J.; Wolff, H.; Shi, Y.-M.; Schrader, J.; Bode, H. B.; Sandmann, G.; Buchhaupt, M.: Expanding the Isoprenoid Building Block Repertoire with an IPP Methyltransferase from Streptomyces monomycini. ACS SYNTHETIC BIOLOGY 8 (6), pp. 1303 - 1313 (2019)
Journal Article
Grammbitter, G. L. C.; Schmalhofer, M.; Karimi, K.; Shi, Y.-M.; Schoener, T. A.; Tobias, N. J.; Morgner, N.; Groll, M.; Bode, H. B.: An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 141 (42), pp. 16615 - 16623 (2019)
Journal Article
Hasan, A.; Yeom, H.-S.; Ryu, J.; Bode, H. B.; Kim, Y.: Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor. SCIENTIFIC REPORTS 9, 20358 (2019)
Journal Article
Kissoyan, K. A. B.; Drechsler, M.; Stange, E.-L.; Zimmermann, J.; Kaleta, C.; Bode, H. B.; Dierking, K.: Natural C-elegans Microbiota Protects against Infection via Production of a Cyclic Lipopeptide of the Viscosin Group. CURRENT BIOLOGY 29 (6), pp. 1030 - + (2019)
Journal Article
Ozkan, H. D.; Cimen, H.; Ulug, D.; Wenski, S.; Ozer, S. Y.; Telli, M.; Aydin, N.; Bode, H. B.; Hazir, S.: Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis. FRONTIERS IN MICROBIOLOGY 10, 2672 (2019)
Journal Article
Schmidt, R.; Ulanova, D.; Wick, L. Y.; Bode, H. B.; Garbeva, P.: Microbe-driven chemical ecology: past, present and future. ISME JOURNAL 13 (11), pp. 2656 - 2663 (2019)
Journal Article
Shi, Y.-M.; Brachmann, A. O.; Westphalen, M. A.; Neubacher, N.; Tobias, N. J.; Bode, H. B.: Dual phenazine gene clusters enable diversification during biosynthesis. NATURE CHEMICAL BIOLOGY 15 (4), pp. 331 - + (2019)
Journal Article
Shi, Y.-N.; Pusch, S.; Shi, Y.-M.; Richter, C.; Macia-Vicente, J. G.; Schwalbe, H.; Kaiser, M.; Opatz, T.; Bode, H. B.: (+/-)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp. JOURNAL OF ORGANIC CHEMISTRY 84 (17), pp. 11203 - 11209 (2019)
Journal Article
Sonner, J. K.; Keil, M.; Falk-Paulsen, M.; Mishra, N.; Rehman, A.; Kramer, M.; Deumelandt, K.; Roewe, J.; Sanghvi, K.; Wolf, L. et al.; von Landenberg, A.; Wolff, H.; Bharti, R.; Oezen, I.; Lanz V, T.; Wanke, F.; Tang, Y.; Brandao, I.; Mohapatra, S. R.; Epping, L.; Grill, A.; Roeth, R.; Niesler, B.; Meuth, S. G.; Opitz, C. A.; Okun, J. G.; Reinhardt, C.; Kurschus, F. C.; Wick, W.; Bode, H. B.; Rosenstiel, P.; Platten, M.: Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. NATURE COMMUNICATIONS 10, 4877 (2019)
Journal Article
Tobias, N. J.; Bode, H. B.: Heterogeneity in Bacterial Specialized Metabolism. SI 431 (23), pp. 4589 - 4598 (2019)
Journal Article
Tobias, N. J.; Parra-Rojas, C.; Shi, Y.-N.; Shi, Y.-M.; Simonyi, S.; Thanwisai, A.; Vitta, A.; Chantratita, N.; Hernandez-Vargas, E. A.; Bode, H. B.: Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand. ENVIRONMENTAL MICROBIOLOGY 21 (8), pp. 2921 - 2932 (2019)
Journal Article
Wang, G.; Zhao, Z.; Ke, J.; Engel, Y.; Shi, Y.-M.; Robinson, D.; Bingol, K.; Zhang, Z.; Bowen, B.; Louie, K. et al.; Wang, B.; Evans, R.; Miyamoto, Y.; Cheng, K.; Kosina, S.; De Raad, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, D. W.; Francavilla, C.; Otani, H.; Deutsch, S.; Washton, N. M.; Rubin, E. M.; Mouncey, N. J.; Visel, A.; Northen, T.; Cheng, J.-F.; Bode, H. B.; Yoshikuni, Y.: CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. NATURE MICROBIOLOGY 4 (12), pp. 2498 - 2510 (2019)
Journal Article
Wenski, S. L.; Kolbert, D.; Grammbitter, G. L. C.; Bode, H. B.: Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL. SI 46 (3-4), pp. 565 - 572 (2019)
Journal Article
Wesche, F.; Adihou, H.; Wichelhaus, T. A.; Bode, H. B.: Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 15, pp. 535 - 541 (2019)
Journal Article
Zhao, L.; Awori, R. M.; Kaiser, M.; Gross, J.; Opatz, T.; Bode, H. B.: Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1. JOURNAL OF NATURAL PRODUCTS 82 (12), pp. 3499 - 3503 (2019)
Journal Article
Zhao, L.; Bode, H. B.: Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68.1. ORGANIC & BIOMOLECULAR CHEMISTRY 17 (34), pp. 7858 - 7862 (2019)
Journal Article
Zhou, Q.; Braeuer, A.; Adihou, H.; Schmalhofer, M.; Saura, P.; Grammbitter, G. L. C.; Kaila, V. R. I.; Groll, M.; Bode, H. B.: Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens. CHEMICAL SCIENCE 10 (25), pp. 6341 - 6349 (2019)
2018
Journal Article
Bozhueyuek, K. A. J.; Fleischhacker, F.; Linck, A.; Wesche, F.; Tietze, A.; Niesert, C.-P.; Bode, H. B.: De novo design and engineering of non-ribosomal peptide synthetases. NATURE CHEMISTRY 10 (3), pp. 275 - 281 (2018)
Report
Bozhüyük, K. A. J.; Bode, H. B.: Innovative Anti-Infectives – Synthetic Biology for the Production of Complex Peptides. (2018)
Report
Bozhüyük, K. A. J.; Bode, H. B.: Wirkstoff-Forschung: Herstellung maßgeschneiderter komplexer Peptide. (2018)
Journal Article
Hacker, C.; Cai, X.; Kegler, C.; Zhao, L.; Weickhmann, A. K.; Wurm, J. P.; Bode, H. B.; Woehnert, J.: Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. NATURE COMMUNICATIONS 9, 4366 (2018)
Journal Article
Macia-Vicente, J. G.; Shi, Y.-N.; Cheikh-Ali, Z.; Gruen, P.; Glynou, K.; Kia, S. H.; Piepenbring, M.; Bode, H. B.: Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery. ENVIRONMENTAL MICROBIOLOGY 20 (3), pp. 1253 - 1270 (2018)
Journal Article
Shi, Y.-M.; Bode, H. B.: Chemical language and warfare of bacterial natural products in bacteria-nematode-insect interactions. NATURAL PRODUCT REPORTS 35 (4), pp. 309 - 335 (2018)
Journal Article
Shi, Y.-M.; Richter, C.; Challinor, V. L.; Gruen, P.; del Rio, A. G.; Kaiser, M.; Schueffler, A.; Piepenbring, M.; Schwalbe, H.; Bode, H. B.: Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus. ORGANIC LETTERS 20 (6), pp. 1563 - 1567 (2018)
Journal Article
Thieme, K. G.; Gerke, J.; Sasse, C.; Valerius, O.; Thieme, S.; Karimi, R.; Heinrich, A. K.; Finkernagel, F.; Smith, K.; Bode, H. B. et al.; Freitag, M.; Ram, A. F. J.; Braus, G. H.: Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism (vol 14, e1007511, 2018). PLOS GENETICS 14 (8), e1007638 (2018)
Journal Article
Thieme, K. G.; Gerke, J.; Sasse, C.; Valerius, O.; Thieme, S.; Karimi, R.; Heinrich, A. K.; Finkernagel, F.; Smith, K.; Bode, H. B. et al.; Freitag, M.; Ram, A. F. J.; Braus, G. H.: Velvet domain protein VosA represses the zinc cluster transcription factor ScIB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism. PLOS GENETICS 14 (7), e1007511 (2018)
Journal Article
Tobias, N. J.; Linck, A.; Bode, H. B.: Natural Product Diversification Mediated by Alternative Transcriptional Starting. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57 (20), pp. 5699 - 5702 (2018)
Journal Article
Tobias, N. J.; Shi, Y.-M.; Bode, H. B.: Refining the Natural Product Repertoire in Entomopathogenic Bacteria. TRENDS IN MICROBIOLOGY 26 (10), pp. 833 - 840 (2018)
Journal Article
Wesche, F.; Adihou, H.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Kaiser, M.; Bode, H. B.: Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides. JOURNAL OF MEDICINAL CHEMISTRY 61 (9), pp. 3930 - 3938 (2018)
Journal Article
Wolff, H.; Bode, H. B.: The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis. PLOS ONE 13 (3), e0194297 (2018)
Journal Article
Zhao, L.; Cai, X.; Kaiser, M.; Bode, H. B.: Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli. JOURNAL OF NATURAL PRODUCTS 81 (10), pp. 2292 - 2295 (2018)
Journal Article
Zhao, L.; Kaiser, M.; Bode, H. B.: Rhabdopeptide/Xenortide-like Peptides from Xenorhabdus innexi with Terminal Amines Showing Potent Antiprotozoal Activity. ORGANIC LETTERS 20 (17), pp. 5116 - 5120 (2018)
2017
Journal Article
Bode, E.; He, Y.; Tien Vo, D.; Schultz, R.; Kaiser, M.; Bode, H. B.: Biosynthesis and function of simple amides in Xenorhabdus doucetiae. ENVIRONMENTAL MICROBIOLOGY 19 (11), pp. 4564 - 4575 (2017)
Book Chapter
Bozhueyuek, K. A. J.; Zhou, Q.; Engel, Y.; Heinrich, A.; Perez, A.; Bode, H. B.: Natural Products from Photorhabdus and Other Entomopathogenic Bacteria. In: MOLECULAR BIOLOGY OF PHOTORHABDUS BACTERIA, pp. 55 - 79 (2017)
Journal Article
Cai, X.; Challinor, V. L.; Zhao, L.; Reimer, D.; Adihou, H.; Gruen, P.; Kaiser, M.; Bode, H. B.: Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria. ORGANIC LETTERS 19 (4), pp. 806 - 809 (2017)
Journal Article
Cai, X.; Nowak, S.; Wesche, F.; Bischoff, I.; Kaiser, M.; Fuerst, R.; Bode, H. B.: Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. NATURE CHEMISTRY 9 (4), pp. 379 - 386 (2017)
Journal Article
Cai, X.; Shi, Y.-M.; Poehlmann, N.; Revermann, O.; Bahner, I.; Pidot, S. J.; Wesche, F.; Lackner, H.; Buechel, C.; Kaiser, M. et al.; Richter, C.; Schwalbe, H.; Stinear, T. P.; Zeeck, A.; Bode, H. B.: Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Go66. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56 (18), pp. 4945 - 4949 (2017)
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