Publications

2024
Journal Article
Touray, M.; Ulug, D.; Gulsen, S. H.; Cimen, H.; Hazir, C.; Bode, H. B.; Hazir, S.: Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus. Pest Management Science (2024)
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Journal Article
Rill, A.; Zhao, L.; Bode, H. B.: Genetic toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling. Microbial Cell Factories 23, 98 (2024)
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Journal Article
Bozhüyük, K. A. J.; Präve, L.; Kegler, C.; Schenk, L.; Kaiser, S.; Schelhas, C. S.; Shi, Y.-N.; Kuttenlochner, W.; Schreiber, M.; Kandler, J. et al.; Alanjary, M.; Mohiuddin, T. M.; Groll, M.; Hochberg, G. K. A.; Bode, H. B.: Evolution-inspired engineering of nonribosomal peptide synthetases. Science 383 (6689), eadg4320 (2024)
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Journal Article
Schmalhofer, M.; Vagstad, A. L.; Zhou, Q.; Bode, H. B.; Groll, M.: Polyketide trimming shapes dihydroxynaphthalene-melanin and anthraquinone pigments. Advanced Science, e2400184 (2024)
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Journal Article
Palma, L.; Frizzo, L.; Kaiser, S.; Berry, C.; Caballero, P.; Bode, H. B.; Valle, D.; E., E.: Genome sequence analysis of native Xenorhabdus strains isolated from entomopathogenic nematodes in Argentina. Toxins 16 (2), 108 (2024)
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Preprint
Peters, L.; Drechsler, M.; Pees, B.; Angelidou, G.; Salzer, L.; Moors, K. A.; Paczia, N.; Schulenburg, H.; Shi, Y.-M.; Kaleta, C. et al.; Witting, M.; Bode, H. B.; Dierking, K.: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans. (2024)
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pre-print
Preprint
Su, L.; Huber, E. M.; Westphalen, M.; Gellner, J.; Bode, E.; Köbel, T.; Grün, P.; Alanjary, M. M.; Glatter, T.; Schindler, D. et al.; Groll, M.; Bode, H. B.: Identification, structure and function of the methyltransferase involved in the biosynthesis of the dithiolopyrrolone antibiotic xenorhabdin. (2024)
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Preprint
Rill, A.; Zhao, L.; Bode, H. B.: Genetic Toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling. (2024)
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2023
Preprint
Spahn, C. K.; Middlemiss, S.; Gómez-de-Mariscal, E.; Henriques, R.; Bode, H. B.; Holden, S.; Heilemann, M.: Transertion and cell geometry organize the Escherichia coli nucleoid during rapid growth. (2023)
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Preprint
Touray, M.; Cimen, H.; Bode, E.; Bode, H. B.; Hazir, S.: Effects of Xenorhabdus and Photorhabdus bacterial metabolites on the ovipositional activity of Aedes albopictus. (2023)
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Journal Article
Abbood, N.; Effert, J.; Bozhüyük, K. A. J.; Bode, H. B.: Guidelines for optimizing type S nonribosomal peptide synthetases. ACS Synthetic Biology 12 (8), pp. 2432 - 2443 (2023)
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Book Chapter
Abbood, N.; Präve, L.; Bozhüyük, K. A. J.; Bode, H. B.: A practical guideline to engineering nonribosomal peptide synthetases. In: Non-Ribosomal Peptide Biosynthesis and Engineering. Methods in Molecular Biology,, Vol. 2670 (Eds. Burkart, M.; Ishikawa, F.). Humana, New York, NY, New York (2023)
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Journal Article
Huber, E. M.; Kreling, L.; Heinrich, A. K.; Dunnebacke, M.; Pothig, A.; Bode, H. B.; Groll, M.: A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments. Structure 31 (5), 573-583.e5. (2023)
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Preprint
Abbood, N.; Effert, J.; Bozhüyük, K. A. J.; Bode, H. B.: Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases. (2023)
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Journal Article
Awori, R. M.; Waturu, C. N.; Pidot, S. J.; Amugune, N. O.; Bode, H. B.: Draft genomes, phylogenomic reconstruction and comparative genome analysis of three Xenorhabdus strains isolated from soil dwelling nematodes in Kenya. Access Microbiology 5 (5), acmi000531.v4 (2023)
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Full
Journal Article
Bode, E.; Assmann, D.; Happel, P.; Meyer, E.; Münch, K.; Roessel, N.; Bode, H. B.: easyPACId, a simple method for induced production, isolation, identification, and testing of natural products from Proteobacteria. Bio-protocol 13 (13), e4709 (2023)
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Journal Article
Cai, X.; Zhao, L.; Bode, H. B.: Engineering of specific single-module nonribosomal peptide synthetases of the RXP type for the production of defined peptides. ACS Synthetic Biology 12 (1), pp. 203 - 212 (2023)
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Journal Article
Jin, G.; Hrithik, M. T. H.; Lee, D.-H.; Kim, I.-H.; Jung, J.-S.; Bode, H. B.; Kim, Y.: Manipulation of GameXPeptide synthetase gene expression by a promoter exchange alters the virulence of an entomopathogenic bacterium, Photorhabdus temperata temperata, by modulating insect immune responses. Frontiers in Microbiology 14, 1271764 (2023)
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Journal Article
Meesil, W.; Muangpat, P.; Sitthisak, S.; Rattanarojpong, T.; Chantratita, N.; Machado, R. A. R.; Shi, Y.-M.; Bode, H. B.; Vitta, A.; Thanwisai, A.: Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria. Scientific Reports 13, 20764 (2023)
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Journal Article
Pandi, A.; Adam, D.; Zare, A.; Trinh, V. T.; Schaefer, S. L.; Burt, M.; Klabunde, B.; Bobkova, E.; Kushwaha, M.; Foroughijabbari, Y. et al.; Braun, P.; Spahn, C. K.; Preußer, C.; Pogge von Strandmann, E.; Bode, H. B.; von Buttlar, H.; Bertrams, W.; Jung, A. L.; Abendroth, F.; Schmeck, B.; Hummer, G.; Vázquez, O.; Erb, T. J.: Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nature Communications 14 (1), 7197 (2023)
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2022
Preprint
Pandi, A.; Adam, D.; Zare, A.; Trinh, V. T.; Schaefer, S. L.; Wiegand, M.; Klabunde, B.; Bobkova, E.; Kushwaha, M.; Foroughijabbari, Y. et al.; Braun, P.; Spahn, C. K.; Preußer, C.; von Strandmann, E. P.; Bode, H. B.; Buttlar, H.; Bertrams, W.; Jung, A. L.; Abendroth, F.; Schmeck, B.; Hummer, G.; Vázquez, O.; Erb, T. J.: Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. (2022)
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Preprint
Bozhüyük, K. A. J.; Präve, L.; Kegler, C.; Kaiser, S.; Shi, Y.-N.; Kuttenlochner, W.; Schenk, L.; Mohiuddin, T. M.; Groll, M.; Hochberg, G. K. A. et al.; Bode, H. B.: Evolution inspired engineering of megasynthetases. (2022)
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Journal Article
Kavakli, S.; Grammbitter, G. L. C.; Bode, H. B.: Biosynthesis of the multifunctional isopropylstilbene in Photorhabdus laumondii involves cross-talk between specialized and primary metabolism. Tetrahedron 128, 133116 (2022)
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Preprint
Kavakli, S.; Grammbitter, G. L. C.; Bode, H. B.: Biosynthesis of the multifunctional isopropylstilbene in Photorhabdus laumondii involves cross-talk between specialized and primary metabolism. (2022)
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Journal Article
Shi, Y.-M.; Crames, J. J.; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Claus, P.; Paczia, N.; Ruckert, C. et al.; Kalinowski, J.; Bange, G.; Bode, H. B.: Genome mining enabled by biosynthetic characterization uncovers a class of benzoxazolinate-containing natural products in diverse bacteria. Angewandte Chemie, International Edition in English 61 (51), e202206106 (2022)
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Journal Article
Muangpat, P.; Meesil, W.; Ngoenkam, J.; Teethaisong, Y.; Thummeepak, R.; Sitthisak, S.; Tandhavanant, S.; Chantratita, N.; Bode, H. B.; Vitta, A. et al.; Thanwisai, A.: Genome analysis of secondary metabolitebiosynthetic gene clusters of Photorhabdus akhurstii subsp. akhurstii and its antibacterial activity against antibiotic-resistant bacteria. PLOS ONE 17 (9), e0274956 (2022)
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Journal Article
Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Bode, H. B.: Cleavage off-loading and post-assembly-line conversions yield products with unusual termini during biosynthesis. ACS Chemical Biology 17 (8), pp. 2221 - 2228 (2022)
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Journal Article
Ahmed, S.; Tafim Hossain Hrithik, M.; Chandra Roy, M.; Bode, H. B.; Kim, Y.: Phurealipids, produced by the entomopathogenic bacteria, Photorhabdus, mimic juvenile hormone to suppress insect immunity and immature development. Journal of Invertebrate Pathology 193, 107799 (2022)
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Journal Article
Gulsen, S. H.; Tileklioglu, E.; Bode, E.; Cimen, H.; Ertabaklar, H.; Ulug, D.; Ertug, S.; Wenski, S. L.; Touray, M.; Hazir, C. et al.; Bilecenoglu, D. K.; Yildiz, I.; Bode, H. B.; Hazir, S.: Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach. Scientific Reports 12 (1), 10779 (2022)
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Journal Article
Abbood, N.; Vo, T. D.; Watzel, J.; Bozhueyuek, K. A. J.; Bode, H. B.: Type S non-ribosomal peptide synthetases for the rapid generation of tailormade peptide libraries. Chemistry – A European Journal 28 (26), e202103963 (2022)
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Journal Article
Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Ahmed, S.; Abebew, D.; Tobias, N. J.; Grun, P.; Crames, J. J.; Pöschel, L.; Kuttenlochner, W. et al.; Richter, C.; Herrmann, J.; Muller, R.; Thanwisai, A.; Pidot, S. J.; Stinear, T. P.; Groll, M.; Kim, Y.; Bode, H. B.: Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nature Chemistry 14, pp. 701 - 712 (2022)
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Journal Article
Sarawi, S.; Shi, Y.-N.; Lotz-Winter, H.; Reschke, K.; Bode, H. B.; Piepenbring, M.: Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. (Agaricales). Phytochemistry 195, 113069 (2022)
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Journal Article
Abebew, D.; Sayedain, F.; Bode, E.; Bode, H. B.: Uncovering nematicidal natural products from Xenorhabdus bacteria. Journal of Agricultural and Food Chemistry 70 (2), pp. 498 - 506 (2022)
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Journal Article
Gerke, J.; Köhler, A. M.; Wennrich, J.-P.; Große, V.; Shao, L.; Heinrich, A. K.; Bode, H. B.; Chen, W.; Surup, F.; Braus, G. H.: Biosynthesis of antibacterial iron-chelating tropolones in Aspergillus nidulans as response to glycopeptide-producing Streptomycetes. Frontiers in Fungal Biology 2, 777474 (2022)
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Magazine Article
Abbood, N.; Bozhüyük, K. A. J.; Bode, H. B.: Synthetische Zipper für die Biosynthese neuer Naturstoffderivate. (2022)
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Full
Journal Article
Zolfaghariyan, S.; Shakeri, A.; Asili, J.; Tarighi, S.; Grün, P.; Shi, Y.-M.; Bode, H. B.; Karimi, J.: Cyclic depsipeptides and linear peptides with cytotoxic and antiphytopathogenic activities from symbiotic bacteria of Xenorhabdus (Enterobacteriales: Morganellaceae) genus. Annals of the Entomological Society of America 116 (2), pp. 114 - 124 (2022)
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2021
Preprint
Kranz, J.; Wenski, S. L.; Dichter, A. A.; Bode, H. B.; Bozhüyük, K. A. J.: Influence of condensation domains on activity and specificity of adenylation domains. (2021)
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Journal Article
Miethke, M.; Pieroni, M.; Weber, T.; Bronstrup, M.; Hammann, P.; Halby, L.; Arimondo, P. B.; Glaser, P.; Aigle, B.; Bode, H. B. et al.; Moreira, R.; Li, Y.; Luzhetskyy, A.; Medema, M. H.; Pernodet, J.-L.; Stadler, M.; Tormo, J. R.; Genilloud, O.; Truman, A. W.; Weissman, K. J.; Takano, E.; Sabatini, S.; Stegmann, E.; Brotz-Oesterhelt, H.; Wohlleben, W.; Seemann, M.; Empting, M.; Hirsch, A. K. H.; Loretz, B.; Lehr, C.-M.; Titz, A.; Herrmann, J.; Jaeger, T.; Alt, S.; Hesterkamp, T.; Winterhalter, M.; Schiefer, A.; Pfarr, K.; Hoerauf, A.; Graz, H.; Graz, M.; Lindvall, M.; Ramurthy, S.; Karlen, A.; van Dongen, M.; Petkovic, H.; Keller, A.; Peyrane, F.; Donadio, S.; Fraisse, L.; Piddock, L. J. V.; Gilbert, I. H.; Moser, H. E.; Muller, R.: Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry 5 (10), pp. 726 - 749 (2021)
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Journal Article
Erkoc, P.; Schmitt, M.; Ingelfinger, R.; Bischoff-Kont, I.; Kopp, L.; Bode, H. B.; Schiffmann, S.; Fuerst, R.: Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells. Biomedicine & Pharmacotherapy 140, 111765 (2021)
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Journal Article
Cimen, H.; Touray, M.; Gulsen, S. H.; Erincik, O.; Wenski, S. L.; Bode, H. B.; Shapiro-Ilan, D.; Hazir, S.: Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii. Applied Microbiology and Biotechnology 105 (13), pp. 5517 - 5528 (2021)
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Journal Article
Behsaz, B.; Bode, E.; Gurevich, A.; Shi, Y.-N.; Grundmann, F.; Acharya, D.; Caraballo-Rodriguez, A. M.; Bouslimani, A.; Panitchpakdi, M.; Linck, A. et al.; Guan, C.; Oh, J.; Dorrestein, P. C.; Bode, H. B.; Pevzner, P. A.; Mohimani, H.: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery (vol 12, 3225, 2021). Nature Communications 12 (1), 4318 (2021)
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Journal Article
Singh, G.; Calchera, A.; Schulz, M.; Drechsler, M.; Bode, H. B.; Schmitt, I.; Dal Grande, F.: Climate-specific biosynthetic gene clusters in populations of a lichen-forming fungus. Environmental Microbiology 23 (8), pp. 4260 - 4275 (2021)
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Journal Article
Behsaz, B.; Bode, E.; Gurevich, A.; Shi, Y.-N.; Grundmann, F.; Acharya, D.; Caraballo-Rodriguez, A. M.; Bouslimani, A.; Panitchpakdi, M.; Linck, A. et al.; Guan, C.; Oh, J.; Dorrestein, P. C.; Bode, H. B.; Pevzner, P. A.; Mohimani, H.: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. Nature Communications 12 (1), 3225 (2021)
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Journal Article
Incedayi, G.; Cimen, H.; Ulug, D.; Touray, M.; Bode, E.; Bode, H. B.; Yaylagul, E. O.; Hazir, S.; Cakmak, I.: Relative potency of a novel acaricidal compound from Xenorhabdus, a bacterial genus mutualistically associated with entomopathogenic nematodes. Scientific Reports 11 (1), 11253 (2021)
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Journal Article
Bozhüyük, K. A. J.; Watzel, J.; Abbood, N.; Bode, H. B.: Synthetic zippers as an enabling tool for engineering of non-ribosomal peptide synthetases**. Angewandte Chemie International Edition 60 (32), pp. 17531 - 17538 (2021)
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Journal Article
Zhao, L.; Le Chapelain, C.; Brachmann, A. O.; Kaiser, M.; Groll, M.; Bode, H. B.: Activation, structure, biosynthesis and bioactivity of glidobactin-like proteasome inhibitors from Photorhabdus laumondii. ChemBioChem 22 (9), pp. 1582 - 1588 (2021)
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Journal Article
Watzel, J.; Duchardt-Ferner, E.; Sarawi, S.; Bode, H. B.; Wohnert, J.: Cooperation between a T domain and a minimal C-terminal docking domain to enable specific assembly in a multiprotein NRPS. Angewandte Chemie International Edition 60 (25), pp. 13685 - 14194 (2021)
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Journal Article
Brachmann, A. O.; Probst, S. I.; Ruethi, J.; Dudko, D.; Bode, H. B.; Piel, J.: A desaturase-like enzyme catalyzes oxazole formation in Pseudomonas indolyloxazole alkaloids. Angewandte Chemie International Edition 60 (16), pp. 8781 - 8785 (2021)
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Journal Article
Watzel, J.; Sarawi, S.; Duchardt-Ferner, E.; Bode, H. B.; Woehnert, J.: NMR resonance assignments for a docking domain pair with an attached thiolation domain from the PAX peptide-producing NRPS from Xenorhabdus cabanillasii. Biomolecular NMR Assignments 15 (1), pp. 229 - 234 (2021)
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Journal Article
Schorn, M. A.; Verhoeven, S.; Ridder, L.; Huber, F.; Acharya, D. D.; Aksenov, A. A.; Aleti, G.; Moghaddam, J. A.; Aron, A. T.; Aziz, S. et al.; Bauermeister, A.; Bauman, K. D.; Baunach, M.; Beemelmanns, C.; Beman, J. M.; Berlanga-Clavero, M. V.; Blacutt, A. A.; Bode, H. B.; Boullie, A.; Brejnrod, A.; Bugni, T. S.; Calteau, A.; Cao, L.; Carrion, V. J.; Castelo-Branco, R.; Chanana, S.; Chase, A. B.; Chevrette, M. G.; Costa-Lotufo, L. V.; Crawford, J. M.; Currie, C. R.; Cuypers, B.; Dang, T.; de Rond, T.; Demko, A. M.; Dittmann, E.; Du, C.; Drozd, C.; Dujardin, J. C.; Dutton, R. J.; Edlund, A.; Fewer, D. P.; Garg, N.; Gauglitz, J. M.; Gentry, E. C.; Gerwick, L.; Glukhov, E.; Gross, H.; Gugger, M.; Guillen Matus, D. G.; Helfrich, E. J. N.; Hempel, B. F.; Hur, J. S.; Iorio, M.; Jensen, P. R.; Kang, K. B.; Kaysser, L.; Kelleher, N. L.; Kim, C. S.; Kim, K. H.; Koester, I.; Konig, G. M.; Leao, T.; Lee, S. R.; Lee, Y. Y.; Li, X.; Little, J. C.; Maloney, K. N.; Mannle, D.; Martin, H. C.; McAvoy, A. C.; Metcalf, W. W.; Mohimani, H.; Molina-Santiago, C.; Moore, B. S.; Mullowney, M. W.; Muskat, M.; Nothias, L. F.; O'Neill, E. C.; Parkinson, E. I.; Petras, D.; Piel, J.; Pierce, E. C.; Pires, K.; Reher, R.; Romero, D.; Roper, M. C.; Rust, M.; Saad, H.; Saenz, C.; Sanchez, L. M.; Sorensen, S. J.; Sosio, M.; Sussmuth, R. D.; Sweeney, D.; Tahlan, K.; Thomson, R. J.; Tobias, N. J.; Trindade-Silva, A. E.; van Wezel, G. P.; Wang, M.; Weldon, K. C.; Zhang, F.; Ziemert, N.; Duncan, K. R.; Crusemann, M.; Rogers, S.; Dorrestein, P. C.; Medema, M. H.; van der Hooft, J. J. J.: A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology 17 (4), pp. 363 - 368 (2021)
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Journal Article
Vo, T. D.; Spahn, C.; Heilemann, M.; Bode, H. B.: Microbial cationic peptides as a natural defense mechanism against insect antimicrobial peptides. ACS Chemical Biology 16 (3), pp. 447 - 451 (2021)
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Journal Article
Sayedain, F. S.; Ahmadzadeh, M.; Fattah-Hosseini, S.; Bode, H. B.: Soil application of entomopathogenic nematodes suppresses the root-knot nematode Meloidogyne javanicain cucumber. Journal of Plant Diseases and Protection 128 (1), pp. 215 - 223 (2021)
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Journal Article
Wenski, S. L.; Berghaus, N.; Keller, N.; Bode, H. B.: Structure and biosynthesis of deoxy-polyamine in Xenorhabdus bovienii. Journal of Industrial Microbiology & Biotechnology 48 (3-4), kuab006 (2021)
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Journal Article
Machado, R. A. R.; Muller, A.; Ghazal, S. M.; Thanwisai, A.; Pages, S.; Bode, H. B.; Hussein, M. A.; Khalil, K. M.; Tisa, L. S.: Photorhabdus heterorhabditis subsp. aluminescens subsp. nov., Photorhabdus heterorhabditis subsp. heterorhabditis subsp. nov., Photorhabdus australis subsp. thailandensis subsp. nov., Photorhabdus australis subsp. australis subsp. nov., and Photorhabdus aegyptia sp. nov. isolated from Heterorhabditis entomopathogenic nematodes. International Journal of Systematic and Evolutionary Microbiology 71 (1), 004610 (2021)
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Journal Article
Reyes-Fernandez, E. Z.; Shi, Y.-M.; Gruen, P.; Bode, H. B.; Boelker, M.: An unconventional melanin biosynthesis pathway in Ustilago maydis. Applied and Environmental Microbiology 87 (3), e01510-20 (2021)
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Journal Article
Maher, A. M. D.; Asaiyah, M.; Quinn, S.; Burke, R.; Wolff, H.; Bode, H. B.; Griffin, C. T.: Competition and co-existence of two Photorhabdus symbionts with a nematode host. Microbial Ecology 81 (1), pp. 223 - 239 (2021)
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Journal Article
Murray, A. E.; Freudenstein, J.; Gribaldo, S.; Hatzenpichler, R.; Hugenholtz, P.; Kampfer, P.; Konstantinidis, K. T.; Lane, C. E.; Papke, R. T.; Parks, D. H. et al.; Rossello-Mora, R.; Stott, M. B.; Sutcliffe, I. C.; Thrash, J. C.; Venter, S. N.; Whitman, W. B.; Acinas, S. G.; Amann, R. I.; Anantharaman, K.; Armengaud, J.; Baker, B. J.; Barco, R. A.; Bode, H. B.; Boyd, E. S.; Brady, C. L.; Carini, P.; Chain, P. S. G.; Colman, D. R.; DeAngelis, K. M.; de los Rios, M. A.; de los Santos, P.; Dunlap, C. A.; Eisen, J. A.; Emerson, D.; Ettema, T. J. G.; Eveillard, D.; Girguis, P. R.; Hentschel, U.; Hollibaugh, J. T.; Hug, L. A.; Inskeep, W. P.; Ivanova, E. P.; Klenk, H.-P.; Li, W.-J.; Lloyd, K. G.; Loffler, F. E.; Makhalanyane, T. P.; Moser, D. P.; Nunoura, T.; Palmer, M.; Parro, V.; Pedros-Alio, C.; Probst, A. J.; Smits, T. H. M.; Steen, A. D.; Steenkamp, E. T.; Spang, A.; Stewart, F. J.; Tiedje, J. M.; Vandamme, P.; Wagner, M.; Wang, F.-P.; Yarza, P.; Hedlund, B. P.; Reysenbach, A.-L.: Roadmap for naming uncultivated Archaea and Bacteria (vol 5, pg 987, 2020). Nature Microbiology 6 (1), p. 136 - 136 (2021)
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2020
Preprint
Grammbitter, G. L. C.; Shi, Y.-M.; Shi, Y.-N.; Vemulapalli, S. P. B.; Richter, C.; Schwalbe, H.; Alanjary, M.; Schüffler, A.; Witt, M.; Griesinger, C. et al.; Bode, H. B.: The chemical structure of widespread microbial aryl polyene lipids. (2020)
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Journal Article
Neubacher, N.; Tobias, N. J.; Huber, M.; Cai, X.; Glatter, T.; Pidot, S. J.; Stinear, T. P.; Lutticke, A. L.; Papenfort, K.; Bode, H. B.: Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat Microbiol 5 (12), pp. 1481 - 1489 (2020)
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Full
Journal Article
Braeuer, A.; Zhou, Q.; Grammbitter, G. L. C.; Schmalhofer, M.; Ruehl, M.; Kaila I, V. R.; Bode, H. B.; Groll, M.: Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis. NATURE CHEMISTRY 12 (8) (2020)
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Journal Article
Kegler, C.; Bode, H. B.: Artificial Splitting of a Non-Ribosomal Peptide Synthetase by Inserting Natural Docking Domains. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 (32), pp. 13463 - 13467 (2020)
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Journal Article
Machado, R. A. R.; Thoenen, L.; Arce, C. C. M.; Theepan, V.; Prada, F.; Wuethrich, D.; Robert, C. A. M.; Vogiatzaki, E.; Shi, Y.-M.; Schaeren, O. P. et al.; Notter, M.; Bruggmann, R.; Hapfelmeier, S.; Bode, H. B.; Erb, M.: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm (Feb, 10.1038/s41587-020-0419-1, 2020). NATURE BIOTECHNOLOGY 38 (5), p. 649 - 649 (2020)
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Journal Article
Machado, R. A. R.; Thonen, L.; Arce, C. C. M.; Theepan, V.; Prada, F.; Wuthrich, D.; Robert, C. A. M.; Vogiatzaki, E.; Shi, Y.-M.; Schaeren, O. P. et al.; Notter, M.; Bruggmann, R.; Hapfelmeier, S.; Bode, H. B.; Erb, M.: Engineering bacterial symbionts of nematodes improves biocontrol potential of the western corn rootworm. NATURE BIOTECHNOLOGY 38 (5) (2020)
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Murray, A. E.; Freudenstein, J.; Gribaldo, S.; Hatzenpichler, R.; Hugenholtz, P.; Kaempfer, P.; Konstantinidis, K. T.; Lane, C. E.; Papke, R. T.; Parks, D. H. et al.; Rossello-Mora, R.; Stott, M. B.; Sutcliffe, I. C.; Thrash, J. C.; Venter, S. N.; Whitman, W. B.; Acinas, S. G.; Amann I, R.; Anantharaman, K.; Armengaud, J.; Baker, B. J.; Barco, R. A.; Bode, H. B.; Boyd, E. S.; Brady, C. L.; Carini, P.; Chain, P. S. G.; Colman, D. R.; DeAngelis, K. M.; de los Rios, M. A.; Estrada-de los Santos, P.; Dunlap, C. A.; Eisen, J. A.; Emerson, D.; Ettema, T. J. G.; Eveillard, D.; Girguis, P. R.; Hentschel, U.; Hollibaugh, J. T.; Hug, L. A.; Inskeep, W. P.; Ivanova, E. P.; Klenk, H.-P.; Li, W.-J.; Lloyd, K. G.; Lffler, F. E.; Makhalanyane, T. P.; Moser, D. P.; Nunoura, T.; Palmer, M.; Parro, V.; Pedros-Alio, C.; Probst, A. J.; Smits, T. H. M.; Steen, A. D.; Steenkamp, E. T.; Spang, A.; Stewart, F. J.; Tiedje, J. M.; Vandamme, P.; Wagner, M.; Wang, F.-P.; Hedlund, B. P.; Reysenbach, A.-L.: Roadmap for naming uncultivated Archaea and Bacteria. NATURE MICROBIOLOGY 5 (8), pp. 987 - 994 (2020)
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Siebels, I.; Nowak, S.; Heil, C. S.; Tufar, P.; Cortina, N. S.; Bode, H. B.; Grininger, M.: Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. ACS SYNTHETIC BIOLOGY 9 (9), pp. 2418 - 2426 (2020)
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Tietze, A.; Shi, Y.-N.; Kronenwerth, M.; Bode, H. B.: Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains. CHEMBIOCHEM 21 (19), pp. 2750 - 2754 (2020)
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Tobias, N. J.; Brehm, J.; Kresovic, D.; Brameyer, S.; Bode, H. B.; Heermann, R.: New Vocabulary for Bacterial Communication. CHEMBIOCHEM 21 (6), pp. 759 - 768 (2020)
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Watzel, J.; Hacker, C.; Duchardt-Ferner, E.; Bode, H. B.; Woehnert, J.: A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from Xenorhabdus bovienii. ACS CHEMICAL BIOLOGY 15 (4), pp. 982 - 989 (2020)
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Wenskil, S. L.; Cimen, H.; Berghaus, N.; Fuchs, S. W.; Hazir, S.; Bode, H. B.: Fabclavine diversity in Xenorhabdus bacteria. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 16, pp. 956 - 965 (2020)
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Zhao, L.; Vo, T. D.; Kaiser, M.; Bode, H. B.: Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity. CHEMBIOCHEM 21 (9), pp. 1288 - 1292 (2020)
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2019
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Reinheimer, C.; Buttner, D.; Proschak, E.; Bode, H. B.; Kempf, V. A. J.; Wichelhaus, T. A.: Anti-tubercular activity of a natural stilbene and its synthetic derivatives. GMS Infect Dis 6, p. Doc01 (2019)
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Full
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Armaleo, D.; Mueller, O.; Lutzoni, F.; Andresson, O. S.; Blanc, G.; Bode, H. B.; Collart, F. R.; Dal Grande, F.; Dietrich, F.; Grigoriev, I. V. et al.; Joneson, S.; Kuo, A.; Larsen, P. E.; Logsdon Jr., J. M.; Lopez, D.; Martin, F.; May, S. P.; McDonald, T. R.; Merchant, S. S.; Miao, V.; Morin, E.; Oono, R.; Pellegrini, M.; Rubinstein, N.; Sanchez-Puerta, M. V.; Savelkoul, E.; Schmitt, I.; Slot, J. C.; Soanes, D.; Szovenyi, P.; Talbot, N. J.; Veneault-Fourrey, C.; Xavier, B. B.: The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata. BMC GENOMICS 20, 605 (2019)
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Berry, D.; Mace, W.; Grage, K.; Wesche, F.; Gore, S.; Schardl, C. L.; Young, C. A.; Dijkwel, P. P.; Leuchtmann, A.; Bode, H. B. et al.; Scott, B.: Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (51), pp. 25614 - 25623 (2019)
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Bode, E.; Heinrich, A. K.; Hirschmann, M.; Abebew, D.; Shi, Y.-N.; Tien Vo, D.; Wesche, F.; Shi, Y.-M.; Gruen, P.; Simonyi, S. et al.; Keller, N.; Engel, Y.; Wenski, S.; Bennet, R.; Beyer, S.; Bischoff, I.; Buaya, A.; Brandt, S.; Cakmak, I.; Cimen, H.; Eckstein, S.; Frank, D.; Fuerst, R.; Gand, M.; Geisslinger, G.; Hazir, S.; Henke, M.; Heermann, R.; Lecaudey, V.; Schaefer, W.; Schiffmann, S.; Schueffler, A.; Schwenk, R.; Skaljac, M.; Thines, E.; Thines, M.; Ulshoefer, T.; Vilcinskas, A.; Wichelhaus, T. A.; Bode, H. B.: Promoter Activation in Delta hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (52), pp. 18957 - 18963 (2019)
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Bozhueyuek, K. A. J.; Linck, A.; Tietze, A.; Kranz, J.; Wesche, F.; Nowak, S.; Fleischhacker, F.; Shi, Y.-N.; Gruen, P.; Bode, H. B.: Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains. NATURE CHEMISTRY 11 (7), pp. 653 - 661 (2019)
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Cai, X.; Zhao, L.; Bode, H. B.: Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides. ORGANIC LETTERS 21 (7), pp. 2116 - 2120 (2019)
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Calchera, A.; Dal Grande, F.; Bode, H. B.; Schmitt, I.: Biosynthetic Gene Content of the "Perfume Lichens' Evernia prunastri and Pseudevernia furfuracea. MOLECULES 24 (1), 203 (2019)
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Drummond, L.; Kschowak, M. J.; Breitenbach, J.; Wolff, H.; Shi, Y.-M.; Schrader, J.; Bode, H. B.; Sandmann, G.; Buchhaupt, M.: Expanding the Isoprenoid Building Block Repertoire with an IPP Methyltransferase from Streptomyces monomycini. ACS SYNTHETIC BIOLOGY 8 (6), pp. 1303 - 1313 (2019)
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Grammbitter, G. L. C.; Schmalhofer, M.; Karimi, K.; Shi, Y.-M.; Schoener, T. A.; Tobias, N. J.; Morgner, N.; Groll, M.; Bode, H. B.: An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 141 (42), pp. 16615 - 16623 (2019)
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Hasan, A.; Yeom, H.-S.; Ryu, J.; Bode, H. B.; Kim, Y.: Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor. SCIENTIFIC REPORTS 9, 20358 (2019)
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Kissoyan, K. A. B.; Drechsler, M.; Stange, E.-L.; Zimmermann, J.; Kaleta, C.; Bode, H. B.; Dierking, K.: Natural C-elegans Microbiota Protects against Infection via Production of a Cyclic Lipopeptide of the Viscosin Group. CURRENT BIOLOGY 29 (6), pp. 1030 - + (2019)
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Ozkan, H. D.; Cimen, H.; Ulug, D.; Wenski, S.; Ozer, S. Y.; Telli, M.; Aydin, N.; Bode, H. B.; Hazir, S.: Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis. FRONTIERS IN MICROBIOLOGY 10, 2672 (2019)
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Schmidt, R.; Ulanova, D.; Wick, L. Y.; Bode, H. B.; Garbeva, P.: Microbe-driven chemical ecology: past, present and future. ISME JOURNAL 13 (11), pp. 2656 - 2663 (2019)
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Shi, Y.-M.; Brachmann, A. O.; Westphalen, M. A.; Neubacher, N.; Tobias, N. J.; Bode, H. B.: Dual phenazine gene clusters enable diversification during biosynthesis. NATURE CHEMICAL BIOLOGY 15 (4), pp. 331 - + (2019)
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Shi, Y.-N.; Pusch, S.; Shi, Y.-M.; Richter, C.; Macia-Vicente, J. G.; Schwalbe, H.; Kaiser, M.; Opatz, T.; Bode, H. B.: (+/-)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp. JOURNAL OF ORGANIC CHEMISTRY 84 (17), pp. 11203 - 11209 (2019)
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Tobias, N. J.; Bode, H. B.: Heterogeneity in Bacterial Specialized Metabolism. SI 431 (23), pp. 4589 - 4598 (2019)
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Tobias, N. J.; Parra-Rojas, C.; Shi, Y.-N.; Shi, Y.-M.; Simonyi, S.; Thanwisai, A.; Vitta, A.; Chantratita, N.; Hernandez-Vargas, E. A.; Bode, H. B.: Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand. ENVIRONMENTAL MICROBIOLOGY 21 (8), pp. 2921 - 2932 (2019)
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Wang, G.; Zhao, Z.; Ke, J.; Engel, Y.; Shi, Y.-M.; Robinson, D.; Bingol, K.; Zhang, Z.; Bowen, B.; Louie, K. et al.; Wang, B.; Evans, R.; Miyamoto, Y.; Cheng, K.; Kosina, S.; De Raad, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, D. W.; Francavilla, C.; Otani, H.; Deutsch, S.; Washton, N. M.; Rubin, E. M.; Mouncey, N. J.; Visel, A.; Northen, T.; Cheng, J.-F.; Bode, H. B.; Yoshikuni, Y.: CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. NATURE MICROBIOLOGY 4 (12), pp. 2498 - 2510 (2019)
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Wenski, S. L.; Kolbert, D.; Grammbitter, G. L. C.; Bode, H. B.: Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL. SI 46 (3-4), pp. 565 - 572 (2019)
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Wesche, F.; Adihou, H.; Wichelhaus, T. A.; Bode, H. B.: Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 15, pp. 535 - 541 (2019)
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Zhao, L.; Awori, R. M.; Kaiser, M.; Gross, J.; Opatz, T.; Bode, H. B.: Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1. JOURNAL OF NATURAL PRODUCTS 82 (12), pp. 3499 - 3503 (2019)
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Zhao, L.; Bode, H. B.: Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68.1. ORGANIC & BIOMOLECULAR CHEMISTRY 17 (34), pp. 7858 - 7862 (2019)
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Zhou, Q.; Braeuer, A.; Adihou, H.; Schmalhofer, M.; Saura, P.; Grammbitter, G. L. C.; Kaila, V. R. I.; Groll, M.; Bode, H. B.: Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens. CHEMICAL SCIENCE 10 (25), pp. 6341 - 6349 (2019)
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2018
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Bozhueyuek, K. A. J.; Fleischhacker, F.; Linck, A.; Wesche, F.; Tietze, A.; Niesert, C.-P.; Bode, H. B.: De novo design and engineering of non-ribosomal peptide synthetases. NATURE CHEMISTRY 10 (3), pp. 275 - 281 (2018)
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Report
Bozhüyük, K. A. J.; Bode, H. B.: Innovative Anti-Infectives – Synthetic Biology for the Production of Complex Peptides. (2018)
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Bozhüyük, K. A. J.; Bode, H. B.: Wirkstoff-Forschung: Herstellung maßgeschneiderter komplexer Peptide. (2018)
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Hacker, C.; Cai, X.; Kegler, C.; Zhao, L.; Weickhmann, A. K.; Wurm, J. P.; Bode, H. B.; Woehnert, J.: Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. NATURE COMMUNICATIONS 9, 4366 (2018)
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Macia-Vicente, J. G.; Shi, Y.-N.; Cheikh-Ali, Z.; Gruen, P.; Glynou, K.; Kia, S. H.; Piepenbring, M.; Bode, H. B.: Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery. ENVIRONMENTAL MICROBIOLOGY 20 (3), pp. 1253 - 1270 (2018)
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