Structure and function of [Fe]-hydrogenase

Research report (imported) 2012 - Max Planck Institute for Terrestrial Microbiology

Authors
Shima, Seigo
Departments
Forschungsgruppe Microbial Protein Structure, assoziiert mit der Emeritus-Gruppe R. Thauer
Summary
Hydrogen (H2) plays a crucial role in global carbon cycles. Hydrogenases - H2 producing and utilizing enzymes - are pivotally involved in biological systems for the turnover of H2. Three types of hydrogenases are known: [NiFe]-, [FeFe]- and [Fe]-hydrogenases. The [Fe]-hydrogenase functions in the methanogenic pathway of hydrogenotrophic methanogenic archaea. This new type of hydrogenase contains a unique iron-guanylylpyridinol (FeGP) cofactor. We are studying the structure and function of both the enzyme and cofactor as well as the FeGP cofactor biosynthesis.

For the full text, see the German version.

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