How anaerobic bacteria and archaea conserve energy

Research report (imported) 2014 - Max Planck Institute for Terrestrial Microbiology


Buckel, Wolfgang

Max Planck Fellow; Mechanism of Enzymes from Anaerobic Bacteria
In clostridia the exergonic reduction of crotonyl-CoA to butyryl-CoA by NADH is coupled to the endergonic reduction of ferredoxin by NADH – a process called flavin-based electron bifurcation, catalyzed by a two-FAD-containing electron transferring flavoptrotein (Etf) and butyryl-CoA dehydrogenase (Bcd). This, and similar systems are wide-spread in anaerobic bacteria and archaea, which reduce ferredoxin for H2 formation in fermentations, for generation of ΔµNa+ via a ferredoxin-NAD reductase (Rnf) and in aceto-and methanogenesis for CO2 reduction by H2.

For the full text, see the German version.

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