Past seminars

Past seminars 2016-2018

Cell wall adhesins in fungal pathogens: A sticky business

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Cell wall stress sensing in the Gram-negative pathogen Vibrio cholerae

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Bacterial shapeshifting: Escherichia coli differentiation during urinary tract infection

Urinary tract infections are caused primarily by uropathogenic strains of Escherichia coli (UPEC). UPEC is known to transition through a series of distinct infection stages, displaying reversible morphological differentiation along the way. Initial steps involve bladder invasion by rod-shaped bacteria to establish intracellular bacterial communities consisting of coccoid cells. Subsequently, during exit from infected cells, UPEC regain their rod-shape and in some cases even form large filaments. Using a flow-chamber based tissue culture infection model we have studied UPEC gene expression during the course of infection. Our results reveal a novel SOS-independent mechanism of reversible cell-division control. [more]

SFB Mini Symposium

Sensing and responding: Terrein production in Aspergillus terreus

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SFB Mini Symposium

Together we are stronger: adaptive benefits drive a division of metabolic labour in bacteria

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Linking metabolic and cell cycle regulation

The cell division cycle consists of a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell cycle. I will present our recent findings that over half of all measured metabolites change significantly through the cell division cycle. We find that the cyclin-dependent kinase Cdk1, a major cell cycle regulator, also controls carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. This demonstrates how cell cycle regulation can entrain carbon metabolism to dynamically fuel biosynthesis during proliferation. [more]

Modeling chemotactic pattern formation in E. coli bacteria

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From ancient lipids to synthetic life

The function of the cell membrane as a barrier and a matrix for biochemical activity relies on the properties imparted by lipids. In eukaryotes, sterols are crucial for modulating the molecular order of membranes. Sterol ordering provides the basis for membrane lateral segregation and promotes a fluid, mechanically robust plasma membrane. How do organisms that lack sterols determine membrane order? Hopanoids are ancient bacterial membrane lipids that have been proposed as putative sterol surrogates. We now explore the role of hopanoids, their effect on membranes in Methylobacterium extorquens and reflect on the path to building functional synthetic membranes. [more]

Oxymonads – eukaryotes without mitochondrion

Mitochondrion is a key evolutionary inventions specific to the eukaryotic cell. Oxymonads remained as one of a few eukaryotic groups, where no mitochondrion has been revealed so far. We have performed detailed genomic and transcriptomic study of oxymonad Monocercomonoides sp., which demonstrates the absence of mitochondrial hallmark proteins. The most striking is the absence of canonical mitochondrial protein import machinery and the substitution of mitochondrial iron sulphur cluster biosynthetic pathway (ISC) by the sulphur mobilization system (SUF). We conclude that Monocercomonoides represents the first report of amitochondriate eukaryote demonstrating the fact that under some circumstances eukaryotes may entirely loose mitochondrion. [more]

SFB Mini Symposium

Global reprogramming of the Yersinia pseudotuberculosis transcriptional landscape in response to temperature and host signals

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SFB Mini Symposium

Understanding activation bacterial promoters

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Genomics-enabled natural product discovery

Natural products have been, without question, the most prolific source of all medicines, especially antibiotics. Genome sequencing has revealed that our knowledge of natural product structure and function is astonishingly incomplete. Therefore, exploration of uncharted natural product chemical space will undoubtedly lead to improved, and entirely new, medicines. Against this backdrop, our group focuses on elucidating the biosynthesis, structure, and function of natural products. This talk will highlight our recent advances in genomics-enabled natural product discovery while covering a few case studies in enzymatic biosynthesis that could be exploited to introduce new drug leads. [more]

Graduate Students Mini-Symposium

Structure and biochemical studies on biosynthesis of the [Fe]-hydrogenase cofactor

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Graduate Students Mini-Symposium

Sugar influx sensing by the phosphotransferase system of Escherichia coli

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SFB Mini Symposium

The Integron: Adaptation on demand

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SFB Mini Symposium

Microbial interactions from a molecular and evolutionary perspective

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Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

The effector protein Ten1 of Ustilago maydis

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Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

PhD Defense

Characterization of the division apparatus in the budding bacterium Hyphomonas neptunium (PhD defense)

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Special seminar

PhD Defense

Comprehensive analysis of peptidoglycan hydrolases in Caulobacter crescentus (PhD Defense)

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Physiology and proteomics of marine heterotrophic bacteria

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Structural features and signalling mechanisms of transmembrane chemoreceptors identified utilizing Nanodiscs

Transmembrane chemoreceptors are central components in the sensory system that mediates bacterial chemotaxis. Like many transmembrane proteins, these receptors are fully active only if inserted in a lipid bilayer. This requirement presents a challenge for in vitro analysis by many biochemical and structural techniques. The challenge is met by Nanodiscs, soluble, nanoscale (~10 nm diameter) particles of lipid bilayer surrounded by an annulus of amphipathic protein into which transmembrane proteins can be incorporated. Using Nanodiscs, we documented that chemoreceptor dimers bend at a specific locus along their 300 Å long axis, discovered that conformational differences between chemoreceptor signalling states were differential propensities of receptor helices to become momentarily unstructured, and determined that chemoreceptor signalling complexes activate and control the chemotaxis histidine kinase by altering its catalytic rate constant. [more]

Special seminar

Special seminar

Oomycete infections of fish

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Special seminar

Bacteria cell shape memory under mechanical stress: Residual strains regulate rod-like cell shape in bacteria

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Antrittsvorlesung

Biophysics of Biofilms

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Mechanistic and evolutionary aspects of gene expression noise in yeast

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Special seminar

Key microbial players for the bioremediation of petroleum hydrocarbons

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Special seminar

Light controlled self-assembly

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PhD Defense

Pan-archaeal analysis of C/D box sRNA biogenesis and methylation targets (PhD Defense)

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The physical ecology of (marine) microbes

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Special seminar

Metabolic lifestyle and energy conservation tricks of giant, symbiotic bacteria – the special case of Epulopiscium

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SFB Mini Symposium

Super complex formation of the denitirification respirasome of Pseudomonas aeruginosa

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SFB Mini Symposium

Regulation of phototaxis in cyanobacteria and how a small cell can detect the direction of light

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SFB Mini Symposium

Structure of mitochondrial complex I

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SFB Mini Symposium

Assembly and mechanism of respiratory complex I

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Skin Microbial Endocrinology: When host neurohormones control bacterial homeostasis

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Special seminar

How are Fe-S cofactors and proteins assembled in plant cells?: Focus on the late steps of the maturation process in organelles

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Mechanisms and regulation of bacterial cell wall growth

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Oxidoreductases for biocatalysis - from screening to function

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PhD Defense

Chromosome arrangement and dynamics in the budding bacterium Hyphomonas neptunium (PhD defense)

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Synchronization of synthetic gene oscillators

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The evolution of symbiosis in cockroaches: a genomic and phylogenetic perspective

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Special seminar

Bacterial chemoreceptors: diversity and conservation

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Special seminar

Deconstructing cell-size control into physiological modules in E. coli

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Special seminar

Bacterial chemoreceptors: diversity and conservation

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PhD Defense

Control of morphogenesis in the budding Alphaproteobacterium Hyphomonas neptunium (PhD defense)

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PhD Defense

Sweets for my sweet: Carbohydrate transport and its regulation in Sulfolobus acidocaldarius (PhD defense)

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SFB Mini Symposium

Sex pheromones and conjugation in gram-positive bacteria

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PhD Defense

Last but not least – Late cell division proteins in Caulobacter crescentus (PhD defense)

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SFB Mini Symposium

Signal transduction by reversible protein phosphorylation in the third domain of life

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SFB Mini Symposium

Inverse toeprinting - A new, high-throughput method for identifying and characterizing ribosome arresting peptides

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Special seminar

The NAD-dependent FdsABG formate dehydrogenase from Cupriavidus necators

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Special seminar

2nd Career Day

9:15 to 9:20Organizers of the 2nd Career DayWelcome9:20 to 9:55Dr. Thomas BühlerSenior Manager Analytical Services Quality - Microbiology (CSL Behring. Marburg, Germany)9:55 to 10:30Dr. Valeria GrassoPlant Pathologist (Syngenta Crop Protection AG. Stein, Switzerland)10:30 to 11:05Dr.-Ing. Ute DechertUnit Head Organisation & Processes (Brain AG. Zwingenberg, Germany)11:20 to 11:55Dr. Kerstin Lassak Trainee Patent Attorney (V.O. Patents & Trademarks. Munich, Germany)11:55 to 12:30Patricia Krause Senior Account Specialist Inhouse Services (Randstad. Marburg, Germany)13:30 to 14:05Dr. Carol Bacchus Vice President & Publishing Director, Research (Wiley-VCH Verlag GmbH & Co. KGaA. Weinheim, Germany)14:05 to 14:40Aileen D’Oria Recruiter - Talent Acquisition EMEA (Thermo Fisher Scientific, Darmstadt, Germany)14:55 to 15:30Thomas Glaeser Senior Recruiter EMEA (Leica Microsystems CMS GmbH. Wetzlar, Germany)15:30 to 16:05Dr. Tomasz Neiner Change Control Specialist (Abbott. Wiesbaden, Germany)16:05 to 16:15Concluding remarks [more]

Delivery and activity of Phytophthora effectors that suppress plant immunity

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SFB Mini Symposium

Bacterial small RNAs in regulatory circuits: interplay with transcription factors and mechanistic insights

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SFB Mini Symposium

Ploidy in prokaryotes: On the seldom cases of monoploidy and the many evolutionary advantages of polyploidy

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Special seminar

Horizon 2020: Presentation on Grants of the European Research Council and Marie Curie Fellowships

„Horizon 2020” – The Framework Programme for Research and Innovation is the main financial instrument supporting European research. Running from 2014 to 2020 with an €77 billion budget, Horizon 2020 lays down the foundations for funding instruments that can be important for researchers of the Max Planck Institutes, such as Grants of the European Research Council or Marie Curie Fellowships. [more]

PhD Defense

Functional characterization of the Ustilago maydis virulence gene scp2 (PhD defense)

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Microbiology Seminar Series

From commensalism to pathogenicity: stages of Candida albicans infections

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Microbiology Seminar Series: SFB Mini Symposium

Bacterial Modern Mass Spectrometric Methods in Life Science Research

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Coevolutionary strategies in tripartite host-virus-virophage systems

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Microbiology Seminar Series: SFB Mini Symposium

Drivers of assembly and coexistence in communities of arbuscular mycorrhizal fungi - the scale matters!

Arbuscular mycorrhizal (AM) fungi are asexual, obligately symbiotic fungi with unique morphology and genomic structure, which occupy a dual niche, that is, the soil and the host root. Consequently, the direct adoption of models for community assembly developed for other organism groups is not evident. Based on recent studies using high throughput molecular methods and their findings, I will give an overview on the factors driving AM fungal community assembly at different scales. By synthesizing these findings, I will show how modern coexistence and assembly theory can be adapted to arbuscular mycorrhizal fungi and that hierarchical spatial structure of arbuscular mycorrhizal fungal communities should be explicitly taken into account in future studies. This conceptual framework developed for arbuscular mycorrhizal fungi is also adaptable for other host-associated microbial communities. [more]

Microbiology Seminar Series: SFB Mini Symposium

Metabolite cross-feeding in synthetic microbial communities: from ecology to biotechnological applications

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Microbiology Seminar Series

Microbial symbionts of leaf-cutting ants (Atta and Acromyrmex)

Leaf-cutting ants harvest substantial amounts of leaf material to cultivate a specialized fungus for food (Leucoagaricus). This complex symbiosis includes at least four coevolved organisms: the farming ants, their fungal crop, a specialized mycoparasite of the ant’s fungal gardens (Escovopsis), and actinomycete bacteria (Pseudonocardia) that the ants culture on their bodies to obtain antibiotics against the parasites. We described an additional symbiosis with Nitrogen-fixing bacteria that colonize the fungus gardens and contribute to supplement the ants’ nutrition. Our present research efforts in Costa Rica focus on potential biotechnological applications of the ants’ microbial symbionts, including bioprospecting for new antibiotics and developing microbial-based biocontrol strategies. [more]

Graduate Students Mini-Symposium

Noise control in signaling pathways

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Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

The development of synthetic CO2 fixation pathways

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Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Bacterial chemotaxis towards compounds in the gut

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Graduate Students Mini-Symposium

Microbiology Seminar Series: SFB Mini Symposium

Light and the life of bacteria - examples from Amsterdam

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Microbiology Seminar Series: SFB Mini Symposium

Eyes of blue: Bacterial photoreceptors with multiple sensing and output functions

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Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Engineering of CO2 fixing reaction cascades to synthesize a diverse library of polyketide extender units

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Graduate Students Mini-Symposium

Synthesis, import and export of ectoines

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Special seminar

Seeking intersections of microbiology, fluid mechanics, and physical chemistry

In this talk I describe various problems involving the intersections of fluid mechanics, bacterial biofilms and physical chemistry. I first highlight our studies of the influence of fluid motion on surface-attached bacteria and biofilms, where we identify and characterize upstream migration of surface-attached bacteria in a flow. Second, I highlight the influence of flow on quorum sensing, which refers to bacterial communication and collective behavior regulated by secreted chemicals. Our results suggest that bacterial colonization and biofilm development under flow can lead to heterogeneous QS activation, which promotes diversity in the genetic programs that bacteria enact. As a consequence, genetically identical bacteria exhibit different behaviours at particular regions and at particular times under flow. Finally, I describe an out-of-equilibrium consequence of concentration gradients, which, perhaps surprisingly, allow movement of particles (e.g. vesicles, DNA) in simple geometries. In particular, with salt gradients, via a mechanism referred to as diffusiophoresis, we can remove particles from dead-end pores or deliver particles into such pores. We explore the phenomenon using experiments and modeling. We close by posing the question if there might be broader consequences of these out-of-equilibrium physical chemistry ideas in biological contexts. [more]

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Robust Population control in Synthetic Communities

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Graduate Students Mini-Symposium

Microbiology Seminar Series

The hidden cost of enzyme catalysis

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Microbiology Seminar Series: SFB Mini Symposium

Microbiology Seminar Series: SFB Mini Symposium

The beauvericin cluster in Fusarium fujikuroi is controlled by a network of pathway-specific and global regulators

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Special seminar

SFB Mini Symposium

Plant developmental rewiring during the AM symbiosis

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SFB Mini Symposium

SR1, the first dual-function sRNA from Bacillus subtilis. Base-pairing and peptide functions

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SFB Mini Symposium

Redox-sensing mechanisms under infection conditions in Staphylococcus aureus

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Microbiology Seminar Series

Speakers from Academia and Industry (see below)

Attendance at the symposium is free of charge, but registration is required. Please register here: http://synmikro.com/news/events/biofilms-in-nature-technology-and-medicine-symposium-2017/registration.html [more]

Microbiology Seminar Series

Lantibiotic resistance in the human pathogen Streptococcus agalactiae

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Microbiology Seminar Series

Effector proteins from the rice blast fungus Magnaporthe oryzae provide novel insight into plant-pathogen interactions

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Special seminar

TEM studies of plant-fungus interactions

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In-House Career Day

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SFB Mini Symposium

Rhodopsins - the green light sensing component of the fungal eye

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Microbiology Seminar Series

Microbiology Seminar Series

Special seminar

Microbiology Seminar Series

Special seminar

Microbiology Seminar Series

Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Metatranscriptomics reveals drainage effects on paddy soil microbiome across all three domains of life

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Graduate Students Mini-Symposium

About the creation and isolation of switching metabolic enzymes

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Graduate Students Mini-Symposium

Microbiology Seminar Series

Cell-wall remodelling drives engulfment during sporulation in Bacillus subtilis

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SFB Mini Symposium

Northern wetlands: a world of unique microbes with difficult characters

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Microbiology Seminar Series

Hyphal growth in oscillation

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Graduate Students Mini-Symposium

Graduate Students Mini-Symposium

Structural variation of type I-F CRISPR RNA guided DNA surveillance

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Graduate Students Mini-Symposium

Microbiology Seminar Series

Structure, function, assembly and engineering of bacterial microcompartments

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Microbiology Seminar Series

PhD Defense

Structure-function analysis of Cmu1, the secreted chorismate mutase from Ustilago maydis (PhD defense)

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SFB/Transregio TRR 174

How to distribute multiple chromosomes along the hyphal cell?

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Microbiology Seminar Series

SFB/Transregio TRR 174

Microbiology Seminar Series

Graduate Students Mini-Symposium

Shining light on the structural features of DNA repair in the PCSf

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Graduate Students Mini-Symposium

Biochemistry of the key spatial regulators MipZ and PopZ in Caulobacter crescentus

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Graduate Students Mini-Symposium

Regulation of peptidoglycan biosynthesis in Hyphomonas neptunium

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MPI Seminar

How proteins control electrons: Protons

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Transregio TRR 174 Seminar

PhD Defense

The design and realization of synthetic pathways for the fixation of carbon dioxide in vitro (PhD defence)

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PhD Defense

Biochemistry of the key spatial regulators MipZ and PopZ in Caulobacter crescentus (PhD defence)

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SFB 987 Mini-Symposium

Microbe-Electrode-Interactions

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SFB 987 Mini-Symposium

*** CANCELED *** Visualizing and quantifying the selfish uptake of high molecular weight polysaccharides by marine bacteria

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Microbiology Seminar Series

Graduate Students Mini-Symposium

Studies on catalytic mechanism of [Fe]-hydrogenase from methanogenic archaea

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Graduate Students Mini-Symposium

Architecture of Vibrio parahaemolyticus swarm-colonies

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Graduate Students Mini-Symposium

Cross-Kingdom RNAi and small RNA trafficking between plants and fungal pathogens

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Transregio TRR 174 Seminar

SFB 987 Mini-Symposium

C A N C E L L E D Chemical interaction between iron-cycling microbes: news from the chat room

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SFB 987 Mini-Symposium

Self-assembly of a bacterial nanomachine: Flagella grow through an injection-diffusion mechanism

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MPI Seminar

D-Amino acids shape the environmental microbial biodiversity

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MPI Seminar

Adaptive genome evolution in the vascular wilt pathogen Verticillium

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SFB 987 Mini-Symposium

Deadly conversation between bacteria

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SFB 987 Mini-Symposium

SFB 987 Mini-Symposium

Genetic circuit design

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SFB 987 Mini-Symposium

SFB 987 Mini-Symposium

Special seminar

Symbioses as sources of evolutionary innovation in insects

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Transregio TRR 174 Seminar

Physiology and cell biology of bacterial epithelia

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MPI Seminar

Molecular tricks of methanogenic archaea

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SFB 987 Mini-Symposium

Activation of the bacterial stringent response

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SFB 987 Mini-Symposium

Bacterial ribosome heterogeneity: Novel aspects of selective translation

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Transregio TRR 174 Seminar

High-resolution whole genome mapping of Sister Chromatid Contacts (Hi-SC2) in Vibrio cholerae

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Microbiology Seminar Series

Exploring molecular landscapes inside cells with in situ cryo-electron tomography

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Special seminar

Viruses of Archaea: what we can learn from them

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