Prof. Dr. Victor Sourjik
Victor Sourjik (born 1970)
Diploma in Physics and Engineering and Magister in Molecular Biology, Moscow Institute of Physics and Technology, 1993
Ph.D. (Dr.rer.nat.), Department of Genetics, University of Regensburg, 1997
Postdoc, Department of Genetics, University of Regensburg, 1997
Postdoc, Department of Molecular and Cellular Biology, Harvard University, 1998
Junior group leader, ZMBH, University of Heidelberg, 2003
Professor of Molecular Biology (W3), ZMBH, University of Heidelberg, 2009
Director and Head of the Department of Systems and Synthetic Microbiology at the MPI in Marburg, part-time since 2013 and full-time since 2014
Professor of Biology and Physics, Philipps-Universität Marburg, since 2014
Research area: Microbial Networks
We are interested in a broad range of topics in quantitative microbiology, using both bacteria (E. coli, B. subtilis) and yeast (S. cerevisiae, S. pombe) as model systems. Our main focus is on quantitative analysis of the spatial organization and real-time functioning of cellular networks. To address these questions, we apply a range of fluorescence microscopy techniques, including FRET, super-resolution microscopy and automated imaging, combined with genomics, proteomics and computational modelling. We aim to elucidate properties that are common to most networks, such as capability to function robustly in a noisy environment, to integrate multiple extra- and intracellular cues, and to self-organize into large multi-protein complexes. We are also interested in combining theoretical and experimental approaches to better understanding the process of network evolution. Beyond individual cells, we investigate self-organization, signal exchange and gene regulation in multicellular microbial communities. Finally, we use our understanding of bacterial cellular networks to construct novel synthetic systems, from biosensors and artificial microbial communities to in-vitro reconstitution of essential cellular processes.
Center for Synthetic Microbiology (SYNMIKRO)
Our department has been established as a part of the
LOEWE Center for Synthetic Microbiology (SYNMIKRO), a joint initiative of the Philipps-Universität Marburg and the Max Planck Institute for Terrestrial Microbiology.
Homepage of V. Sourjik at SYNMIKRO
Selected recent publications
Typas A, Sourjik V (2015) Bacterial protein networks: properties and functions. Nat Rev Microbiol 13: 559-572.
Yang Y, A. P, Hofler C, Poschet G, Wirtz M, Hell R, Sourjik V (2015) Relation between chemotaxis and consumption of amino acids in bacteria. Mol Microbiol 96: 1272-1282.
Krembel AK, Neumann S, Sourjik V (2015) Universal response-adaptation relation in bacterial chemotaxis. J Bacteriol 197: 307-313.
Bubendorfer S, Koltai M, Rossmann F, Sourjik V, Thormann KM (2014) Secondary bacterial flagellar system improves bacterial spreading by increasing the directional persistence of swimming. Proc Natl Acad Sci U S A 111: 11485-11490.
Press MO, Li H, Creanza N, Kramer G, Queitsch C, Sourjik V, Borenstein E (2013) Genome-scale co-evolutionary inference identifies functions and clients of bacterial Hsp90. PLoS Genet 9: e1003631.
Neumann S, Grosse K, Sourjik V (2012) Chemotactic signaling via carbohydrate phosphotransferase systems in Escherichia coli. Proc Natl Acad Sci U S A 109: 12159-12164.
Kumar M, Sourjik V (2012) Physical map and dynamics of the chaperone network in Escherichia coli. Mol Microbiol 84: 736-747.
Oleksiuk O, Jakovljevic V, Vladimirov N, Carvalho R, Paster E, Ryu WS, Meir Y, Wingreen NS, Kollmann M, Sourjik V (2011) Thermal robustness of signaling in bacterial chemotaxis. Cell 145: 312-321.
Di Ventura B, Sourjik V (2011) Self-organized partitioning of dynamically localized proteins in bacterial cell division. Mol Syst Biol 7: 457.
Neumann S, Hansen CH, Wingreen NS, Sourjik V (2010) Differences in signalling by directly and indirectly binding ligands in bacterial chemotaxis. EMBO J 29: 3484-3495.
Kumar M, Mommer MS, Sourjik V (2010) Mobility of cytoplasmic, membrane, and DNA-binding proteins in Escherichia coli. Biophys J 98: 552-559.
Kentner D, Sourjik V (2010) Use of fluorescence microscopy to study intracellular signaling in bacteria. Annu Rev Microbiol 64: 373-390.
Lovdok L, Bentele K, Vladimirov N, Muller A, Pop FS, Lebiedz D, Kollmann M, Sourjik V (2009) Role of translational coupling in robustness of bacterial chemotaxis pathway. PLoS Biol 7: e1000171.
Kentner D, Sourjik V (2009) Dynamic map of protein interactions in the Escherichia coli chemotaxis pathway. Mol Syst Biol 5: 238.