Prof. Dr. Victor Sourjik

Microbial Networks

Curriculum Vitae

Victor Sourjik (born 1970)
Diploma in Physics and Engineering and Magister in Molecular Biology, Moscow Institute of Physics and Technology, 1993
Ph.D. (Dr.rer.nat.), Department of Genetics, University of Regensburg, 1997
Postdoc, Department of Genetics, University of Regensburg, 1997
Postdoc, Department of Molecular and Cellular Biology, Harvard University, 1998
Junior group leader, ZMBH, University of Heidelberg, 2003
Professor of Molecular Biology (W3), ZMBH, University of Heidelberg, 2009
Director and Head of the Department of Systems and Synthetic Microbiology at the MPI in Marburg, part-time since 2013 and full-time since 2014
Professor of Biology and Physics, Philipps-Universität Marburg, since 2014

Research area: Microbial Networks

We are interested in a broad range of topics in quantitative microbiology, using both bacteria (E. coli, B. subtilis) and yeast (S. cerevisiae, S. pombe) as model systems. Our main focus is on quantitative analysis of the organization and molecular and physiological functions of cellular networks in microorganisms. We use fluorescence microscopy and other techniques to investigate the ability of these networks to sense and integrate multiple environmental and internal stimuli, to reliably control cell behavior or physiology and to spatially organize within the cell. We further aim to better understand the relationship between the single-cell and collective behavior within microbial communities, including cell differentiation and communication. We use experimental evolution and competition to obtain insights into the selection pressure on cellular functions and their evolvability. In most of our work, we combine experiments with theoretical analysis and computational modeling to elucidate principles that are common to various biological systems, such as suppression and utilization of biological variation and self-organization. Finally, we explore how cellular functions might be reengineered for potential applications and aim for an in-vitro reconstitution of essential cellular processes. 

Center for Synthetic Microbiology (SYNMIKRO)

The group of Victor Sourjik as per November 2017

Our department has been established as a part of the
LOEWE Center for Synthetic Microbiology (SYNMIKRO), a joint initiative of the Philipps-Universität Marburg and the Max Planck Institute for Terrestrial Microbiology.
Homepage of V. Sourjik at SYNMIKRO

Selected recent publications

Schauer O, Mostaghaci B, Colin R, Hürtgen D, Kraus D, Sitti M, Sourjik V. (2018) Motility and chemotaxis of bacteria-driven microswimmers fabricated using antigen 43-mediated biotin display. Sci Rep., doi: 10.1038/s41598-018-28102-9.[link]

Lopes JG, Sourjik V. (2018) Chemotaxis of Escherichia coli to major hormones and polyamines present in human gut. ISME J., doi: 10.1038/s41396-018-0227-5. PMID: 29995838 [link]

Bi S, Jin F, Sourjik V. (2018) Inverted signaling by bacterial chemotaxis receptors. Nat Commun., 9, 2927, doi: 10.1038/s41467-018-05335-w. PMID: 30050034 [link]

Colin, R., Rosazza, C., Vaknin, A., and Sourjik, V. (2017). Multiple sources of slow activity fluctuations in a bacterial chemosensory network. eLife 6. [link]

Yuan, J., Jin, F., Glatter, T., and Sourjik, V. (2017). Osmosensing by the bacterial PhoQ/PhoP two-component system. Proc Natl Acad Sci USA, doi: 10.1073/pnas.1717272114.[link]

Paulick, A., Jakovljevic, V., Zhang, S., Erickstad, M., Groisman, A., Meir, Y., Ryu, W.S., Wingreen, N.S., and Sourjik, V. (2017) Mechanism of bidirectional thermotaxis in Escherichia coli. eLife 6[link]

Colin, R., and Sourjik, V. (2017). Emergent properties of bacterial chemotaxis pathway. Curr Opin Microbiol 39, 24-33. [link]

Murray, S., and Sourjik, V. (2017). Self-organisation and positioning of bacterial protein clusters. Nature Physics 13, 1006–1013. [link]

Ni, B., Ghosh, B., Paldy, F.S., Colin, R., Heimerl, T., and Sourjik, V. (2017). Evolutionary Remodeling of Bacterial Motility Checkpoint Control. Cell Rep 18, 866-877. [link]

Laganenka L, Colin R, Sourjik V (2016) Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli. Nat Commun 7: 12984. [link]

Besharova O, Suchanek VM, Hartmann R, Drescher K, Sourjik V (2016) Diversification of Gene Expression during Formation of Static Submerged Biofilms by Escherichia coli. Front Microbiol 7: 1568. [link]

Bi S, Pollard AM, Yang Y, Jin F, Sourjik V (2016) Engineering hybrid chemotaxis receptors in bacteria. ACS Synth Biol, 5: 989-1001 [link]

Banderas A, Koltai M, Anders A, Sourjik V (2016) Sensory input attenuation allows predictive sexual response in yeast. Nat Commun 7: 12590. [link]

Somavanshi R, Ghosh B, Sourjik V (2016) Sugar influx sensing by the phosphotransferase system of Escherichia coli. PLoS Biol 14: e2000074. [link]

Typas A, Sourjik V (2015) Bacterial protein networks: properties and functions. Nat Rev Microbiol 13: 559-572. [link]

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