Contact

Dr. Tobias Erb
Dr. Tobias Erb
Director
Phone: +49 6421 178 700
Fax: +49 6421 178 809
Carmen Stubner
Assistant
Phone: +49 6421 178 800
Fax: +49 6421 178 809

Research Group Members

Martina Carrillo Camacho
Phone: +49 6421 178 711
Dr. Nina Socorro Cortina
Scientific Staff Member
Phone: +49 6421 178 733
Fax: +49 6421 178 999
Sonja Fleissner
Phone: +49 6421 178 740
Patrick Gerlinger
Ph.D. Student
Phone: +49 6421 178 424
Kyra Geyer
Ph.D. Student
Phone: +49 6421 178 722
Iria Grundling
Ph.D. Student
Phone: +49 6421 178 711
Katharina Kremer
Katharina Kremer
Phone: +49 6421 178 722
Richard McLean
Richard McLean
Ph.D. Student
Phone: + 49 6421 178 811
Fax: + 49 6421 178 809
Tarryn Miller
Tarryn Miller
Ph.D. Student
Phone: +49 6421 178 741
Fax: +49 6421 178 999
Pascal Pfister
Phone: +49 6421 178 740
Dr. Lennart Schada von Borzyskowski
Dr. Lennart Schada von Borzyskowski
Postdoctoral Fellow
Phone: +49 6421 178 721
Fax: +49 6421 178 999
Marieke Scheffen
Marieke Scheffen
Ph.D. Student
Phone: +49 6421 178 430
Ole Schumann
Master Student
Thomas Schwander
Thomas Schwander
Ph.D. Student
Phone: +49 6421 178 733
Fax: +49 6421 178 999
Gabriele Stoffel
Gabriele Stoffel
Ph.D. Student
Phone: +49 6421 178 710
Dr. Srividhya Sundaram
Postdoctoral Fellow
Phone: +49 6421 178 742
Bastian Vögeli
Ph.D. Student
Phone: +49 6421 178 711
Fax: +49 6421 178 999
Dr. Jan Zarzycki
Phone: +49 6421 178 742

Dr. Tobias Erb - Understanding and Building Metabolism

Dr. Tobias Erb

Curriculum Vitae

Tobias Jürgen Erb (born 1979)
Diploma in Biology, University of Freiburg (D), 2005
Magister scientiarum in Chemistry & Biology, University of Freiburg (D), 2005
Visiting scholar, The Ohio State University (US), 2007
Dr. rer. nat., Institute of Microbiology, University of Freiburg (D), 2009
DFG-Postdoctoral fellow, University of Illinois (US), 2009-2011
ETH-Fellow, Institute of Microbiology, ETH Zürich (CH), 2011-2012
Jr. Group leader & SNF-Ambizione fellow, ETH Zürich (CH), 2012-2014
Elected member of the Junge Akademie at the BBAW and Leopoldina 2013
Max Planck Research Group Leader (free floater) at the MPI Marburg, 2014-2017
Director and Head of the Department of Biochemistry and Synthetic Metabolism at the MPI Marburg, since 2017

Research area: Understanding and building metabolism

Metabolism is one of the key features of living systems. In our everyday life we experience it in different forms: Plants, algae and many microorganism perform photosynthesis and convert carbon dioxide into carbohydrates. Other organisms (including us humans) consume the fixed carbon to cover their energetic needs, which closes the global cycle of carbon.

From a scientific point of view, metabolism can be defined as the dynamic biochemistry of life that provides cells with the energy and the building blocks required for their three- and four-dimensional self-organization.

In our lab, we aim at understanding and applying the fundamental design principles of metabolism. On the one hand, we study the function and organization of natural metabolism in the context of the living cell. On the other hand, we use our understanding to build novel, synthetic metabolism in a bottom-up fashion.

Our research is strongly team-oriented and highly interdisciplinary. Together we aim at transforming biology from an analytical-descriptive approach into a synthetic-constructive discipline that will allow us to find new solution for human needs (e.g., increased photosynthesis productivity or designer routes for the direct conversion of carbon dioxide into chemical and pharmaceutical building blocks or biofuels).

More about Understanding and Building Metabolism

The group of Tobias Erb as per August 2017
The group of Tobias Erb as per August 2017
 

Selected Recent Publications

Schwander, T., Schada von Borzyskowski, L., Burgener, S., Cortina, N.S., and *Erb, T.J. (2016) A synthetic pathway for the fixation of carbon dioxide in vitro. Science 354:901-904 http://science.sciencemag.org/content/354/6314/900

Rosenthal, R.G., Vögeli, B., Quade, N., Capitani, G., Kiefer, P., Vorholt, J.A., Ebert, M.-O., and *Erb, T.J. (2015) The use of ene adducts to study and engineer enoyl-thioester reductases. Nature Chemical Biology 11:398-400 http://www.nature.com/nchembio/journal/v11/n6/full/nchembio.1794.html

Könneke, M., Schubert, D.M., Brown, P.C., Hügler, M., Standfest, S., Schwander, T., Schada von Borzyskowski, L., Erb, T.J., Stahl, D.A. and Berg, I.A. (2014) Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation. Proceedings of the National Academy of Sciences 111:8239-8244 http://www.pnas.org/content/111/22/8239

Rosenthal, R.G., Ebert, M.-O., Kiefer, P., Peter, D.M., Vorholt, J.A. and *Erb, T.J. (2014) Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes. Nature Chemical Biology 10:50-55 http://www.nature.com/nchembio/journal/v10/n1/abs/nchembio.1385.html

Erb, T.J., Evans, B.S., Kyuil, C., Warlick, B.P., Sriram, J., Wood, B.M., Sweedler, J.V., Tabita, F.R., Gerlt, J.A. (2012). A RubisCO-like protein links SAM metabolism and isoprenoid biosynthesis. Nature Chemical Biology 8:926-923 http://www.nature.com/nchembio/journal/v8/n11/full/nchembio.1087.html

*Erb, T.J., Kiefer, P., Hattendorf, B., Günther, D., Vorholt, J.A. (2012) GFAJ-1 is an arsenate resistant, phosphate dependent organism. Science 337:467-70 http://science.sciencemag.org/content/early/2012/07/06/science.1218455

Selected Honors

VAAM-Research Award, Association of General & Applied Microbiology (D), 2017

Heinz Maier-Leibnitz-Prize, German Resarch Foundation (DFG) & German Federal Minstry of Education and Research (BMBF), 2016

C&EN "Talented 12": Up-and-coming chemists of 2015, American Chemical Society

ERC-Starting Grantee 2015

SGM-Encouragement award, Swiss Society of Microbiology, 2013

Election and appointment as member of die Junge Akademie, 2013

Poster Award 22nd Enzyme Mechanisms Conference (US), 2011

Richard I. Gumport Travel Award, University of Illinois at Urbana-Champaign (US), 2011

VAAM-PhD Award, Association of General & Applied Microbiology (D), 2010

Hans-Grisebach Prize, University of Freiburg (D), 2010

Alumni-Diploma Award, University of Freiburg (D), 2006

 
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