Publications

2020 | 2019 | 2018 | 2017 | 2016 | 2015-2011 | 2010-2005 |

2019

Ni B, Colin R, Link H, Endres RG, Sourjik V. (2019)
Growth-rate dependent resource investment in bacterial motile behavior quantitatively follows potential benefit of chemotaxis. Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 201910849. doi: 10.1073/pnas.1910849117.

Díaz-Pascual F., Hartmann R., Lempp M., Vidakovic L., Song B., Jeckel H., Thormann KM., Yildiz FH., Dunkel J., Link H., Nadell CD., Drescher K. (2019)
Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function. Nat Microbiol. 2019 Oct 28. doi: 10.1038/s41564-019-0579-2.

Laganenka L, Sander T, Lagonenko A, Chen Y, Link H, Sourjik V (2019)
Quorum Sensing and Metabolic State of the Host Control Lysogeny-Lysis Switch of Bacteriophage T1. MBio. 2019 Sep 10;10(5). pii: e01884-19. doi: 10.1128/mBio.01884-19.

Lempp M, Farke N, Kuntz M, Freibert S, Lill R, Link H  (2019)
Systematic identification of metabolites controlling gene expression in E. coli. Nature Communications 10, 4463. doi: 10.1038/s41467-019-12474-1

Sander T, Wang CY, Glatter T, Link H (2019)
CRISPRi-based downregulation of transcriptional feedback improves growth and metabolism of arginine overproducing E. coli. ACS Synthetic Biology. doi: 10.1021/acssynbio.9b00183. 

Boecker S, Zahoor A, Schramm T, Link H, Klamt S (2019)
Broadening the Scope of Enforced ATP Wasting as a Tool for Metabolic Engineering in Escherichia coli. Biotechnol J. 2019 Mar 30:e1800438. doi: 10.1002/biot.201800438

Sander T, Farke N, Diehl C, Kuntz M, Glatter T, Link H (2019)
Allosteric feedback inhibition enables robust amino acid biosynthesis in E. coli by enforcing enzyme overabundance. Cell Systems 8, 1-10. doi: 10.1016/j.cels.2018.12.005

2018

Beuter D, Gomes-Filho J, Randau L, Díaz-Pascual F, Drescher K, Link H (2018
Selective enrichment of slow-growing bacteria in a metabolism-wide CRISPRi library with a TIMER protein. ACS Synthetic Biology. doi: 10.1021/acssynbio.8b00379

Christodoulou D, Link H, Fuhrer T, Kochanowski K, Gerosa L, Sauer U (2018) 
Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress. Cell Systems 6 (5), 569-578. e7 doi: 10.1016/j.cels.2018.04.009

Krink-Koutsoubelis N, Löchner AC, Lechner A, Link H, Denby C, Vögeli B, Erb TJ, Yuzawa S, Jakociunas T, Katz L, Jensen MK,  Sourjik V, Keasling, JD (2018)
Engineered production of short chain acyl-coenzyme A esters in S. cerevisiae. ACS Synthetic Biology 7 (4), 1105-1115 doi: 10.1021/acssynbio.7b00466

Donati S, Sander T, Link H (2018)
Crosstalk between transcription and metabolism: how much enzyme is enough for a cell? WIREs Syst Biol Med 10 (1), e1396 doi: 10.1002/wsbm.1396

2017

Han D, Link H, Liesack W (2017)
Response of Methylocystis sp. Strain SC2 to Salt Stress: Physiology, Global Transcriptome, and Amino Acid Profiles. Applied and Environmental Microbiology 83, e00866-17.           

Gundlach J, Herzberg C, Hertel D, Thürmer A, Daniel R, Link H, Stülke J (2017)
Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation. mBio 8, e00861-17.

Moretti M, Wang L, Grognet P, Lanver D, Link H, Kahmann R (2017)
Three regulators of G protein signaling differentially affect mating, morphology and virulence in the smut fungus Ustilago maydis. Molecular Microbiology 105, 901-921. 

Guder JC , Schramm T, Sander T, Link H (2017)
Time-Optimized Isotope Ratio LC-MS/MS for High-Throughput Quantification of Primary Metabolites. Analytical Chemistry 89 (3), 1624-1631.

2016

Liu Y*, Link H*, Liu L, Du G, Chen J, Sauer U (2016) 
A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis. Nature Communications 7: 11933. *equal contribution

2015 - 2011

Link H, Fuhrer T, Gerosa L, Zamboni N, Sauer U (2015)
Real-time metabolome profiling of the metabolic switch between starvation and growth. Nature Methods. doi:10.1038/nmeth.3584.
Research Highlight in: Miura G (2015) Metabolomics: Budgeting on a diet. Nature Chemical Biology 11: 828-828.

Link H, Christodoulou D, Sauer U (2014)
Advancing metabolic models with kinetic information. Current Opinion in Biotechnology 29, 8-14.

Botella E, Devine SK, Hubner S, Salzberg LI, Gale RT, Brown ED, Link H, Sauer U, Codée JD, Noone D, Devine KM (2014)
PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellular PAS domain during the PhoPR-mediated phosphate limitation response of Bacillus subtilis. Molecular Microbiology 94, 1242-1259.

Link H, Kochanowski K, Sauer U (2013)
Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo. Nature Biotechnology 31, 357-361.

Chubukov V, Uhr M, Le Chat L, Kleijn RJ, Jules M, Link H, Aymerich S, Stelling J, Sauer U (2013)
Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis. Molecular Systems Biology 9, 709.

Link H, Buescher JM, Sauer U (2012)
Targeted and quantitative metabolomics in bacteria. In Harwood C, Wipat A (ed.): Systems Biology of Bacteria. Methods in Microbiology, vol. 39 Elsevier, 127-150.

Braun M, Link H, Liu L, Schmid RD, Weuster-Botz D (2011)
Biocatalytic process optimization based on mechanistic modeling of cholic acid oxidation with cofactor regeneration. Biotechnology and Bioengineering 108, 1307-1317.

Link H, Weuster-Botz D (2011)
Upstream Processing: Medium Formulation and Development. In Murray Moo-Young (ed.): Comprehensive Biotechnology, vol. 2 Elsevier, 119-134.

2010 - 2005

Link H, Anselment B, Weuster-Botz D (2010)
Rapid media transition: An experimental approach for steady state analysis of metabolic pathways. Biotechnology Progress 26, 1-10.

Link H, Anselment B, Weuster-Botz D (2008)
Leakage of adenylates during cold methanol/ glycerol quenching of Escherichia coli. Metabolomics 4, 240-247.

Link H, Weuster-Botz D (2007)
Steady state analysis of metabolic pathways: comparing the double modulation method and the lin-log approach. Metabolic Engineering 9, 433-441.

Link H, Vera J, Torres NV, Weuster-Botz D, Franco-Lara E (2007)
Multi-objective steady state optimization of biochemical reaction networks using a constrained genetic algorithm. Computers and Chemical Engineering 32, 1707-1713.

Tiemeyer A, Link H, Weuster-Botz D (2007)
Kinetic studies on autohydrogenotrophic growth of Ralstonia eutropha with nitrate as terminal electron acceptor. Applied Microbiology and Biotechnology 76, 75-81.

Link H, Weuster-Botz D (2006)
Genetic algorithm for multi-objective experimental optimization. Bioprocess and Biosystems Engineering 29, 385-390.

Franco-Lara E, Link H, Weuster-Botz D (2006)
Evaluation of artificial neural networks for modelling and optimization of medium composition with a genetic algorithm. Process Biochemistry 41, 2200-2206.

Havel J, Link H, Hofinger M, Franco-Lara E, Weuster-Botz D (2006)
Comparison of genetic algorithms for experimental multi-objective optimization on the example of medium design for cyanobacteria. Biotechnology Journal 5, 549-555.

Amidjojo M, Franco-Lara E, Nowak A, Link H, Weuster-Botz D (2005)
Asymmetric synthesis of tert-butyl (3R, 5S) 6-chlorodihydroxyhexanoate with Lactobacillus kefir. Applied Microbiology and Biotechnology 69, 9-15.

Go to Editor View