Publications

2021

R. Hartmann*, H. Jeckel*, E. Jelli*, P.K. Singh, S. Vaidya, M. Bayer, D. Rode, L. Vidakovic, F. Díaz-Pascual, J.C.N. Fong, A. Dragoš, O. Besharova, J.G. Thöming, N. Netter, S. Häussler, C.D. Nadell, V. Sourjik, A.T. Kovács, F.H. Yildiz, K. Drescher (2021)
Quantitative image analysis of microbial communities with BiofilmQ. Nature Microbiology 6, 151-156.

S. Wimmi, A. Balinovic, H. Jeckel, L. Selinger, D. Lampaki, E. Eisemann, I. Meuskens, D. Linke, K. Drescher, U. Endesfelder, A. Diepold (2021)
Dynamic relocalization of the cytosolic type III secretion system components ensures specific protein secretion. Nature Communications, in press.

H. Jeckel, K. Drescher (2021)
Advances and opportunities in image analysis of bacterial cells and communities. FEMS Microbiology Reviews, fuaa062.

K. Drescher, J. Dunkel (2021)
Learning principles of bacterial biofilm dynamics from the behavior of single cells. Physical Biology, in press.

D.J. Skinner, B. Song, H. Jeckel, E. Jelli, K. Drescher, J. Dunkel (2021)
Topological metric detects hidden order in disordered media. Physical Review Letters 126, 048101 

2020

M. Maestre‐Reyna, W.‐C. Huang, W.‐J. Wu, P.K. Singh, R. Hartmann, P.‐H. Wang, C.‐C. Lee, T. Hikima, M. Yamamoto, Y. Bessho, K. Drescher, M.‐D. Tsai, A.H.‐J. Wang (2020)
Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate‐dependent autoproteolysis activity. IUBMB Life 73, 418-431.

R. Herzog, N. Peschek, P.K. Singh, M. Sprenger, F. Meyer, K.S. Fröhlich, L. Schröger, M. Bramkamp, K. Drescher, K. Papenfort (2020)
RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio choleraeNature Communications 11, 6067.

D.K.H. Rode*, P.K. Singh*, K. Drescher (2020)
Multicellular and unicellular responses of microbial biofilms to stress. Biological Chemistry 401, 1365–1374.

T. Ishikawa, T.J. Pedley, K. Drescher, R.E. Goldstein (2020) 
Stability of dancing VolvoxJournal of Fluid Mechanics 903, A11. 

R. Hartmann*, M.C.F. van Teeseling*, M. Thanbichler, K. Drescher (2020)
BacStalk: a comprehensive and interactive image analysis software tool for bacterial cell biology. 
Molecular Microbiology 114, 140-150.

S.B. Otto, M. Martin, D. Schäfer, R. Hartmann, K. Drescher, S. Brix, A. Dragoš, A.T. Kovács (2020)
Privatization of biofilm matrix in structurally heterogeneous biofilms. 
mSystems 5, e00425-20.

C. Schwechheimer, K. Hebert, S. Tripathi, P.K. Singh, K.A. Floyd, E.R. Brown, M.E. Porcella, J. Osorio, J.T.M. Kiblen, F.A. Pagliai, K.Drescher, S.M. Rubin, F.H. Yildiz (2020)
A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae
PLOS Pathogens 16, e1008745.

A.L. Gallego-Hernandez, W.H. DePas, J.H. Park, J.K. Teschler, R. Hartmann, H. Jeckel, K. Drescher, S. Beyhan, D.K. Newman, F.H. Yildiz (2020)
Upregulation of virulence genes promotes Vibrio cholerae biofilm hyperinfectivity. PNAS 117, 11010–11017.

S. Brückner, R. Schubert, T. Kraushaar, R. Hartmann, D. Hoffmann, E. Jelli, K. Drescher, D.J. Müller, L.-O. Essen, H.-U. Mösch (2020)
Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family. 
eLife 9, e55587.

E.L. Simmons, M.C. Bond, B. Koskella, K. Drescher, V. Bucci, C.D. Nadell (2020)
Biofilm structure promotes coexistence of phage-resistant and phage-susceptible bacteria. mSphere 5, e00877-19.

2019

P. Pearce, B. Song, D.J. Skinner, R. Mok, R. Hartmann, P.K. Singh, H. Jeckel, J.S. Oishi, K. Drescher, J. Dunkel (2019)
Flow-induced symmetry breaking in growing bacterial biofilms. Physical Review Letters 123, 258101. (abstract)

Colin R, Drescher K, Sourjik V. (2019)
Chemotactic behaviour of Escherichia coli at high cell density. Nat Commun. 2019 Nov 25;10(1):5329. doi: 10.1038/s41467-019-13179-1.

Nisbett LM, Binnenkade L, Bacon BA, Hossain S, Kotloski NJ, Brutinel ED, Hartmann R, Drescher K, Arora DP, Muralidharan S, Thormann K, Gralnick JA, Boon EM. (2019)
NosP signaling modulates the NO/H-NOX-mediated multicomponent c-di-GMP network and biofilm formation in Shewanella oneidensis. Biochemistry. 2019 Nov 4. doi: 10.1021/acs.biochem.9b00706.

Díaz-Pascual F., Hartmann R., Lempp M., Vidakovic L., Song B., Jeckel H., Thormann KM., Yildiz FH., Dunkel J., Link H., Nadell CD., Drescher K. (2019)
Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function. Nat Microbiol. 2019 Oct 28. doi: 10.1038/s41564-019-0579-2.

Hartmann R., Singh PK., Pearce P., Mok R., Song B., Díaz-Pascual F., Dunkel J., Drescher K. (2019)
Emergence of three-dimensional order and structure in growing biofilms. Nat Phys. 2019 Apr 26;15(3):251-256. doi: 10.1038/s41567-018-0356-9

Jeckel H, Matthey N, Drescher K. (2019)
Common concepts for bacterial collectives.Elife. 2019 Apr 30;8. pii: e47019. doi: 10.7554/eLife.47019.

Jeckel H, Jelli E, Hartmann R, Singh PK, Mok R, Totz JF, Vidakovic L, Eckhardt B, Dunkel J, Drescher K. (2019)
Learning the space-time phase diagram of bacterial swarm expansion. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1489-1494. doi: 10.1073/pnas.1811722116.

2018

Beuter D, Gomes-Filho JV, Randau L, Díaz-Pascual F, Drescher K, Link H. (2018)
Selective Enrichment of Slow-Growing Bacteria in a Metabolism-Wide CRISPRi Library with a TIMER Protein. ACS Synth Biol. 2018 Dec 21;7(12):2775-2782. doi: 10.1021/acssynbio.8b00379.

A. Dragos, H.T. Kiesewalter, M. Martin, C.-Y. Hsu, R. Hartmann, T. Wechsler, K. Drescher, N. Stanley-Wall, R. Kümmerli, A.T. Kovacs (2018)
Division of labor during biofilm matrix production. Current Biology, 2018 Jun 18;28(12):1903-1913.e5. doi: 10.1016/j.cub.2018.04.046.

R. Martinez-Garcia, C.D. Nadell, R. Hartmann, K. Drescher, J.A. Bonachela (2018)
Cell adhesion and fluid flow jointly initiate biofilm genetic structure. PLOS Computational Biology, 2018 Apr 16;14(4):e1006094. doi: 10.1371/journal.pcbi.1006094

L. Vidakovic, P.K. Singh, R. Hartmann, C.D. Nadell, K. Drescher (2018)
Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Nature Microbiology 3, 26-31. doi: 10.1038/s41564-017-0050-1

M. Simmons, K. Drescher, C.D. Nadell, V. Bucci (2018)
Phage mobility is a core determinant of phage-bacteria coexistence in biofilms. ISME Journal 12, 531-543, doi: 10.1038/ismej.2017.190

2017

P.K. Singh, S. Bartalomej, R. Hartmann, H. Jeckel, L. Vidakovic, C.D. Nadell, K. Drescher (2017)
Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal. Current Biology 27, 1-8. (abstract)

J.C. Fong, A. Rogers, A.K. Michael, N.C. Parsley, W.C. Cornell, Y.C. Lin, P.K. Singh, R. Hartmann, K. Drescher, E. Vinogradov, L.E. Dietrich, C.L. Partch, F.H. Yildiz (2017)
Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. eLife 6, e26163. 

C.D. Nadell, D. Ricaurte, J. Yan, K. Drescher, B.L. Bassler (2017)
Flow environment and matrix structure interact to determine spatial competition in Pseudomonas aeruginosa biofilms. eLife 6, e21855. 

2016

C.D. Nadell, R. Hartmann, K. Drescher (2016)
An emerging grip on the growth of grounded bacteria. ACS Nano 10, 9109-9110 (2016).

O. Besharova, V.M. Suchanek, R. Hartmann, K. Drescher, V. Sourjik (2016)
Diversification of Gene Expression during Formation of Static Submerged Biofilms by Escherichia coli.Frontiers in Microbiology  7, 1568 (2016).

C.D. Nadell, K. Drescher, K.R. Foster (2016)
Spatial structure, cooperation, and competition in biofilms. Nature Reviews Microbiology 14, 589-600 (2016).

K. Drescher, J. Dunkel, C.D. Nadell, S. van Teeffelen, I. Grnja, N.S. Wingreen, H.A. Stone, B.L. Bassler (2016)
Architectural transitions in Vibrio cholerae biofilms at single-cell resolution. Proceedings of the National Academy of Sciences 113, E2066–E2072 (2016).

2015

A. Persat, C.D. Nadell, K.M. Kim, F. Ingremeau, A. Siryaporn, K. Drescher, N.S. Wingreen, B.L. Bassler, Z. Gitai, H.A. Stone (2015)
The mechanical world of bacteria. Cell 161, 988-997

C.D. Nadell, K. Drescher, N.S. Wingreen, B.L. Bassler (2015)
Extracellular matrix structure governs invasion resistance in bacterial biofilms. ISME Journal 9, 1700-1709

2014

K. Drescher, C.D. Nadell, H.A. Stone, N.S. Wingreen, B.L. Bassler (2014)
Solutions to the public goods dilemma in bacterial biofilms. Current Biology 24, 50-55

M.K. Kim, K. Drescher, O.S. Pak, B.L. Bassler, H.A. Stone (2014)
Filaments in curved streamlines: Rapid formation of Staphylococcus aureus biofilm streamers. New Journal of Physics 16, 065024

2013

C.T. O'Loughlin, L.C. Miller, A. Siryaporn, K. Drescher, M.F. Semmelhack, B.L. Bassler (2013)
A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proceedings of the National Academy of Sciences 110, 17981-17986

K. Drescher, Y. Shen, B.L. Bassler, H.A. Stone (2013)
Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems. Proceedings of the National Academy of Sciences 110, 4345-4350

J. Dunkel, S. Heidenreich, K. Drescher, H.H. Wensink, M. Bär, R.E. Goldstein (2013)
Fluid dynamics of bacterial turbulence. Physical Review Letters 110, 228102

C.D. Nadell, V. Bucci, K. Drescher, S.A. Levin, B.L. Bassler, J.B. Xavier (2013)
Cutting through the complexity of cell collectives. Proceedings of the Royal Society B 280, 20122770

S. Sareh, J. Rossiter, A. Conn, K. Drescher, R.E. Goldstein (2013)
Swimming like algae: biomimetic soft artificial cilia. Journal of the Royal Society Interface 10, 20120666

2012

H.H. Wensink, J. Dunkel, S. Heidenreich, K. Drescher, R.E. Goldstein, H. Löwen, J.M. Yeomans (2012)
Meso-scale turbulence in living fluids. Proceedings of the National Academy of Sciences 109, 14308-14313

2011

K. Drescher, J. Dunkel, L.H. Cisneros, S. Ganguly, R.E. Goldstein (2011)
Fluid dynamics and noise in bacterial cell-cell and cell-surface interactions. Proceedings of the National Academy of Sciences 108, 10940-10945

C.A. Solari, K. Drescher, R.E. Goldstein (2011)
The flagellar photoresponse in Volvox species. Journal of Phycology 47, 580-583

C.A. Solari, K. Drescher, S. Ganguly, J.O. Kessler, R.E. Michod, R.E. Goldstein (2011)
Flagellar phenotypic plasticity in volvocalean algae correlates with Péclet number. Journal of the Royal Society Interface 8, 1409-1417

2010

K. Drescher, R.E. Goldstein, N. Michel, M. Polin, I. Tuval  (2010)
Direct measurement of the flow field around swimming microorganisms. Physical Review Letters 105, 168101

K. Drescher, R.E. Goldstein, I. Tuval (2010)
Fidelity of adaptive phototaxis. Proceedings of the National Academy of Sciences 107, 11171-11176 (2010).

2009

M. Polin, I. Tuval, K. Drescher, J.P. Gollub, R.E. Goldstein (2009)
Chlamydomonas swims with two 'gears' in a eukaryotic version of run-and-tumble locomotion. Science 325, 487-490

K. Drescher, K.C. Leptos, I. Tuval, T. Ishikawa, T.J. Pedley, R.E. Goldstein (2009)
Dancing Volvox: Hydrodynamic bound states of swimming algae. Physical Review Letters 102, 168101

K. Drescher, K.C. Leptos, R.E. Goldstein (2009)
How to track protists in three dimensions. Review of Scientific Instruments 80, 014301

D.P. Bulte, K. Drescher, P. Jezzard (2009)
Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. Magnetic Resonance in Medicine 61, 391-398

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