Controlling the T3SS in health and disease
The better understanding about the molecular function and regulation of the T3SS that we want to achieve has important practical implications, and we directly apply our research results to be able to efficiently control the function of the T3SS. By comparing regulatory principles of the T3SS of various pathogens during infection, we can identify conserved targets that allow to inhibit toxin delivery, and subsequently virulence, in many important pathogens. In addition, we use our knowledge on the regulation of the T3SS to engineer bacteria, for example for controlled protein delivery to host cells through the T3SS. Beyond their direct potential in biotech and medicine, both approaches will advance our understanding of T3SS function and regulation, and therefore feed back into our core research.