Publications

2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000

2020

Neubacher, N., Tobias, N. J., Huber, M., Cai, X., Glatter, T., Pidot, S. J., Stinear, T. P., Lütticke, A. L., Papenfort, K. and Bode, H. B. (2020)
Symbiosis, virulence and natural product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat. Microbiol. 2020 Nov 2. doi: 10.1038/s41564-020-00797-5.

Maher, A. M. D., Asaiyah, M., Quinn, S., Burke, R., Wolff, H., Bode, H. B. and Griffin, C. T. (2020)
Competition and co-existence of two photorhabdus symbionts with a nematode host. Microb. Ecol. 2020 Aug 21. doi: 10.1007/s00248-020-01573-y.

Siebels, I., Nowak, S., Heil, C. S., Tufar, P., Cortina, N. S., Bode, H. B. and Grininger, M. (2020)
Cell-free synthesis of natural compounds from genomic DNA of biosynthetic gene clusters. ACS Synth Biol. 9 (9), 2418-2426. doi: 10.1021/acssynbio.0c00186.

Bräuer, A., Zhou, Q., Grammbitter, G. L. C., Schmalhofer, M., Rühl, M., Kaila, V. R. I., Bode, H. B. and Groll, M. (2020)
Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis. Nat. Chem.12 (8), 755-763. doi: 10.1038/s41557-020-0491-7.

Murray, A. E., Freudenstein, J., Gribaldo, S., Hatzenpichler, R., Hugenholtz, P., Kämpfer, P., Konstantinidis, K. T., Lane, C. E., Papke, R. T., Parks, D. H., Rossello-Mora, R., Stott, M. B., Sutcliffe, I. C., Thrash, J. C., Venter, S. N., Whitman, W. B., Acinas, S. G., Amann, R. I., Anantharaman, K., Armengaud, J., Baker, B. J., Barco, R. A., Bode, H. B., Boyd, E. S., Brady, C. L., Carini, P., Chain, P. S. G., Colman, D. R., DeAngelis, K. M., de Los Rios, M. A., Estrada-de Los Santos, P., Dunlap, C. A., Eisen, J. A., Emerson, D., Ettema, T. J. G., Eveillard, D., Girguis, P. R., Hentschel, U., Hollibaugh, J. T., Hug, L. A., Inskeep, W. P., Ivanova, E. P., Klenk, H. P., Li, W. J., Lloyd, K. G., Löffler, F. E., Makhalanyane, T. P., Moser, D. P., Nunoura, T., Palmer, M., Parro, V., Pedrós-Alió, C., Probst, A. J., Smits, T. H.M., Steen, A. D., Steenkamp, E. T., Spang, A., Stewart, F. J., Tiedje, J. M., Vandamme, P., Wagner, M., Wang, F. P., Hedlund, B. P. and Reysenbach, A. L. (2020)
Roadmap for naming uncultivated Archaea and Bacteria. Nat Microbiol5 (8), 987-994. doi: 10.1038/s41564-020-0733-x.

Wenski, S. L., Cimen, H., Berghaus, N., Fuchs, S. W., Hazir, S. and Bode, H. B. (2020)
Fabclavine diversity in Xenorhabdus bacteria. Beilstein J. Org. Chem. 16, 956-965. doi: 10.3762/bjoc.16.84.

Tietze, A., Shi, Y. N., Kronenwerth, M. and Bode, H. B. (2020)
Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains. ChemBioChem. 21 (19), 2750-2754. doi: 10.1002/cbic.202000176.

Kegler, C. and Bode, H. B. (2020)
Artificial Splitting of a Non-Ribosomal Peptide Synthetase by Inserting Natural Docking Domains. Angew. Chem. Int. Ed. Engl. 59(32), 13463-13467. doi: 10.1002/anie.201915989.

Watzel, J., Hacker, C., Duchardt-Ferner, E., Bode, H. B. and Wöhnert, J. (2020)
A new docking domain type in the peptide-antimicrobial-Xenorhabdus peptide producing nonribosomal peptide synthetase from Xenorhabdus bovienii. ACS Chem. Biol. 15 (4), 982-989. doi: 10.1021/acschembio.9b01022.

Machado, R. A. R., Thönen, L., Arce, C. C. M., Theepan, V., Prada, F., Wüthrich, D., Robert, C. A. M., Vogiatzki, E., Shi, Y. M., Schaeren, O. P., Notter, M., Bruggmann, R., Hapfelmeier, S., Bode, H. B. and Erb, M. (2020)
Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm. Nat. Biotechnol. 38 (5), 649. doi: 10.1038/s41587-020-0478-3.

Zhao, L., Vo, T. D., Kaiser, M., Bode, H. B. (2020)
Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity. ChemBioChem. 21 (9), 1288-1292. doi: 10.1002/cbic.201900665.

 

2019

Tobias, N. J., Brehm, J., Kresovic, D., Brameyer, S., Bode, H. B. and Heermann, R. (2019)
New Vocabulary for Bacterial Communication. ChemBioChem. 21 (6), 759-768. doi: 10.1002/cbic.201900580.

Schmidt, R., Ulanova, D., Wick, L. Y., Bode, H. B. and Garbeva, P. (2019)
Microbe-driven chemical ecology: past, present and future. ISME J. 13, 2656-2663. doi: 10.1038/s41396-019-0469-x.

Tobias, N. J. and Bode, H. B. (2019)
Heterogeneity in Bacterial Specialized Metabolism. J. Mol. Biol. 431 (23), 4589-4598. doi: 10.1016/j.jmb.2019.04.042.

Hasan, A., Yeom, H. S., Ryu, J., Bode, H. B. & Kim, Y. (2019)
Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor. Sci Rep. 9 (1), 20358. doi: 10.1038/s41598-019-56892-z.

Donmez Ozkan, H., Cimen, H., Ulug, D., Wenski, S., Yigit Ozer, S., Telli, M., Aydin, N., Bode, H . B. & Hazir, S. (2019)
Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis. Front Microbiol. 10, 2672. doi: 10.3389/fmicb.2019.02672.

Zhao, L., Awori, R. M., Kaiser, M., Groß, J., Opatz, T., Bode, H. B. (2019)
Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1. J. Nat. Prod. 82 (12), 3499-3503. doi: 10.1021/acs.jnatprod.9b00932

Berry, D., Mace, W., Grage, K., Wesche, F., Gore, S., Schardl, C. L., Young, C.A., Dijkwel, P. P., Leuchtmann, A., Bode, H. B. & Scott, B. (2019)
Efficient non-enzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS. PNAS 116 (51), 25614-25623. doi: 10.1073/pnas.1913080116

Bode, E., Heinrich, A. K., Hirschmann, M., Abebew, D., Shi, Y. N., Vo, T. D., Wesche, F., Shi, Y. M., Grün, P., Simonyi, S., Keller, N., Engel, Y., Wenski, S., Bennet, R., Beyer, S., Bischoff, I., Buaya,  A., Brandt, S., Cakmak, I., Çimen, H., Eckstein, S., Frank, D., Fürst, R., Gand, M., Geisslinger, G., Hazir, S., Henke, M., Heermann, R., Lecaudey, V., Schäfer, W., Schiffmann, S., Schüffler, A., Schwenk, R., Skaljac, M., Thines, M., Thines, E., Ulshöfer, T., Vilcinskas, A., Wichelhaus, T. A. & Bode, H. B. (2019)
Promoter activation in ∆hfq mutants as an efficient tool for specialized metabolite production enabling direct bioactivity testing. Angew. Chem. Int. Ed. 58, 18957-18963. doi: 10.1002/anie.201910563, VIP paper.

Sonner, J. K., Keil, M., Falk-Paulsen, M., Mishra, N., Rehman, A., Kramer, M., Deumelandt, K., Röwe, J., Sanghvi, K., Wolf, L., von Landenberg, A., Wolff, H., Bharti, R., Oezen, I., Lanz, T. V., Wanke, F., Tang, Y., Brandao, I., Mohapatra, S. R., Epping, L., Grill, A., Röth, R., Niesler, B., Meuth, S. G., Opitz, C. A., Okun, J. G., Reinhardt, C., Kurschus, F. C.,  Wick, W., Bode, H. B., Rosenstiel, P. & Platten, M. (2019)
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. Nat. Commun. 10 (1), 4877. doi: 10.1038/s41467-019-12776-4.

Wang, G., Zhao, Z., Ke, J., Engel, Y., Shi, Y. M., Robinson, D., Bingol, K., Zhang, Z., Bowen, B., Louie, K., Wang, B., Evans, R., Miyamoto, Y., Cheng, K., Kosina, S., De Raad, M., Silva, L., Luhrs, A., Lubbe, A., Hoyt, D. W., Francavilla, C., Otani, H., Deutsch, S., Washton, N. C., Rubin, E. M., Mouncey, N. J., Visel, A., Northen, T., Cheng, J. F., Bode, H. B. and Yoshikuni, Y. (2019)
Chassis-independent recombinase-assisted genome engineering enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. Nat. Microbiol.4, 2498-2510. doi: 10.1038/s41564-019-0573-8.

Shi, Y. N., Pusch, S., Shi, Y. M., Richter, C., Macia-Vicente, J. G., Schwalbe, H., Kaiser, M., Opatz, T. and Bode, H. B. (2019)
 (±) Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp. J. Org. Chem. 84 (17), 11203-11209. doi: 10.1021/acs.joc.9b01229.

Zhao, L. and Bode, H. B. (2019)
Production of a photohexapaptide library from entomopathogenic Photorhabdus asymbiotics PB68.1. Org. Biomol. Chem. 17 (34), 7858-7862. doi: 10.1039/c9ob01489f.

Zhou, Q., Bräuer, A., Adihou, H., Schmalhofer, M., Saura, P., Grammbitter, G. L. C., Kaila, V. R. I., Groll, M. and Bode, H. B. (2019)
Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens. Chem. Sci. 10 (25), 6341-6349. doi: 10.1039/c9sc00749k.

Armaleo, D., Müller, O., Lutzoni, F., Andrésson, Ó. S., Blanc. G., Bode, H. B., Collart, F. R., Dal Grande, F., Dietrich, F., Grigoriev, I. V., Joneson, S., Kuo, A., Larsen, P. E., Logsdon, J. M. Jr., Lopez, D., Martin, F., May, S. P., McDonald, T. R., Merchant, S. S., Miao, V., Morin, E., Oono, R., Pellegrini, M., Rubinstein, N., Sanchez-Puerta, M. V., Savelkoul, E., Schmitt, I., Slot, J. C., Soanes, D., Szövényi, P., Talbot, N. J., Veneault-Fourrey, C. and Xavier, B. B. (2019)
The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata. BMC Genomics 20, 605. doi: 10.1186/s12864-019-5629-x.

Bozhüyük, K. A. J., Linck, A., Tietze, A., Kranz, J., Wesche, F., Nowak, S., Fleischhacker, F., Shi, Y. N., Grün, P. and Bode, H. B. (2019)
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains. Nat. Chem. 11 (7), 653-661. doi: 10.1038/s41557-019-0276-z.

Tobias, N. J., Parra-Rojas, C., Shi, Y. N., Shi, Y. M., Simonyi, S., Thanwisai, A., Vitta, A., Chantratita, N., Hernandez-Vargas, E. A. and Bode, H. B. (2019)
Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand. Environ. Microbiol. 21 (8), 2921-2932. doi: 10.1111/1462-2920.14685.

Drummond, L., Kschowak, M. J., Breitenbach, J., Wolff, H., Shi, Y. M., Schrader, J., Bode, H. B., Sandmann, G. and Buchhaupt, M. (2019)
Expanding the isoprenoid building block repertoire with an IPP methyltransferase from Streptomyces monomycini. ACS Synth Biol. 8 (6), 1303-1313. doi: 10.1021/acssynbio.8b00525

Grammbitter, G. L. C., Schmalhofer, M., Karimi, K., Shi, Y. M., Schöner, T. A., Tobias, N. J., Morgner, N., Groll, M. and Bode, H. B. (2019)
An uncommon type II PKS catalyzes biosynthesis of aryl polyene pigments. J. Am. Chem. Soc., 141 (42), 16615-16623. doi: 10.1021/jacs.8b10776.

Shi, Y. M., Brachmann, A. O., Westphalen, M., Neubacher, N., Tobias, N. J. and Bode, H, B. (2019)
Dual phenazine gene clusters enable diversification during biosynthesis. Nat. Chem. Biol. 15, 331-339. doi: 10.1038/s41589-019-0246-1.

Cai, X., Zhao, L. and Bode, H. B. (2019)
Reprogramming Promiscous Nonribosomal Peptide Synthetases for Production of Specific Peptides. Org. Lett. 21 (7), 2116-2120. doi: 10.1021/acs.orglett.9b00395

Wesche, F., Adihou, H., Wichelhaus, T. A. and Bode, H. B. (2019)
Synthesis and SAR of the antistapylococcal natural product nematophin from Xenorhabdus nematophila. Beilstein J. Org. Chem. 15, 535-541. doi: 10.3762/bjoc.15.47

Calchera, A., Dal Grande, F., Bode, H. B. and Schmitt, I. (2019)
Biosynthetic Gene Content of the ‘Perfume Lichens’ Evernia prunastri and Pseudevernia furfuracea. Molecules 24 (1), 203. doi: 10.3390/molecules24010203.

Wenski, S. L., Kolbert, D., Grammbitter, G. L.C. and Bode, H. B. (2019)
Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL. J. Ind. Microbiol. Biotechnol. 46 (3-4), 565-572. doi: 10.1007/s10295-018-02124-8.

Kissoyan, K. A. B., Drechsler, M., Stange, E. L., Zimmermann, J., Kaleta, C., Bode, H. B. and Dierking, K. (2019)
Natural C. elegans Microbiota protects against infection via production of a cyclic lipopeptide of the Viscosin group. Curr. Biol. 29 (6), 1030-1037. doi: 10.1016/j.cub.2019.01.050.

 

2018

Tobias, N. J., Shi, Y. M. and Bode, H. B. (2018)
Refining the natural product repertoire in entomopathogenic bacteria. Trends. Microbiol., 26, 833-840. doi: 10.1016/j.tim.2018.04.007.

Shi, Y. M. and Bode, H. B. (2018)
Chemical language and warfare of bacterial natural products in bacteria-nematode-insect interactions. Nat. Prod. Rep., 35, 309-335. doi: 10.1039/c7np00054e.

Reinheimer, C., Büttner, D., Proschak, E., Bode, H. B., Kempf, V. A. J. and Wichelhaus,  T. A. (2018)
Anti-Tubercular activity of a natural stilbene and its synthetic derivative. GMS Infect Dis. 6: Doc01. doi: 10.3205/id000036. eCollection 2018.

Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A. K., Wurm, J. P., Bode, H. B. and Wöhnert, J. (2018)
Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. Nat. Commun. 9 (1), 4366. doi: 10.1038/s41467-018-06712-1.

Zhao, L., Cai, X., Kaiser, M. and Bode, H. B. (2018)
Methionine-containing Rhabdopeptide/Xenortide-like peptides from heterologous expression of the biosynthetic gene cluster kj12ABC in Escherichia coli. J. Nat. Prod. 81 (10), 2292-2295. doi: 10.1021/acs.jnatprod.8b00425.

Zhao, L., Kaiser, M. and Bode, H. B. (2018)
Rhabdopeptide/Xenortide-like peptides from Xenorhabdus innexi with terminal amines showing potent antiprotozoal activity. Org. Lett. 20 (17), 5116–5120. doi: 10.1021/acs.orglett.8b01975.

Thieme, K. G., Gerke, J., Sasse, C., Valerius, O., Theme, S., Karimi, R., Heinrich, A. K., Finkernagel, F., Smith, K., Bode, H. B., Freitag, M., Ram, A. F. J., Braus, G. H. (2018)
Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism. PLoS Genetics, 14 (8): e1007511. doi: 10.1371/journal.pgen.1007638.

Wesche, F., Adihou, H., Kaiser, A., Wurglics, M., Schubert-Zsilavecz, M., Kaiser, M. and Bode, H. B. (2018)
Combined approach of backbone amide linking and on-resin N-methylation for the synthesis of bioactive and metabolically stable peptides. J. Med. Chem. 61, 3930-3938. doi: 10.1021/acs.jmedchem.7b01809.

Wolff, H. and Bode, H. B. (2018)
The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis. PLoS One, 13: e0194297. doi: 10.1371/journal.pone.0194297.

Tobias, N. J., Linck, A. and Bode, H. B. (2018)
Natural product diversification mediated by alternative transcriptional starting. Angew. Chem. Int. Ed. 57, 5699-5702. doi: 10.1002/anie.201713199.

Shi, Y. M., Richter, C., Challinor, V. L., Grün, P., Girela Del Rio, A., Kaiser, M., Schüffler, A., Piepenbring, M., Schwalbe, H. and Bode, H. B. (2018)
Georatusin, a specific antiparasitic polyketide-peptide hybrid from the fungus Geomyces auratus, Org. Lett. 20, 1563-1567. doi: 10.1021/acs.orglett.8b00293.

Macia-Vicente, J. G., Shi, Y.-N., Cheikh-Ali, Z., Grün, P., Glynou, K., Kia, S. H., Piepenbring, M. and Bode, H. B. (2018)
Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery, Environ. Microbiol. 20, 1252-1270. doi: 10.1111/1462-2920.14072.

Bozhüyük, K. A. J., Fleischhacker, F., Linck, A., Wesche, F., Tietze, A., Niesert, C.-P. and Bode, H. B. (2018)
De novo design and engineering of non-ribosomal peptide synthetases. Nat. Chem. 10, 275-281. doi: 10.1038/nchem.2890.

 

2017

Bozhüyük, K. A., Zhou, Q., Engel, Y., Heinrich, A., Pérez, A. and Bode, H. B. (2017)
Natural products from Photorhabdus and other entomopathogenic bacteria. Curr. Top Microbiol, Immunol. 402, 55-79. doi: 10.1007/82_2016_24.

Gottardi, M., Grün, P., Bode, H. B., Hoffmann, T., Schwab, W., Oreb, M., Boles, E. (2017)
Optimization of trans-cinnamic acid and hydrocinnamoyl alcohol with recombinant Saccharomyces cerevisiae and identification of cinnamyl methyl ketone as a by-product. FEMS Yeast Res., 17 (8). doi: 10.1093/femsyr/fox091.

Tobias, N. J., Wolff, H., Djahanschiri, B., Grundmann, F., Kronenwerth, M., Shi, Y.-M., Simonyi, S., Grün, P., Shapiro-Ilan, D., Pidot, S. J., Stinear, T. P., Ebersberger, I. and Bode, H. B. (2017)
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat. Microbio.2, 1676-1685. doi: 10.1038/s41564-017-0039-9.

Bode, E., He, Y., Vo, T. D., Schultz, R., Kaiser, M. and Bode, H. B. (2017)
Biosynthesis and function of simple amides in Xenorhabdus doucetiae. Environ. Microbiol. 19, 4564-4575. doi: 10.1111/1462-2920.13919.

Petersen, L. M., LaCourse, K., Schöner, T. A., Bode, H. and Tisa, L. S. (2017)
Inactivation of the major hemolysin gene influences expression of the nonribosomal peptides synthetase gene swrA in the insect pathogen Serratia sp. strain SCB1. J. Bacteriol. 199, pii: JB.00333-17. doi: 10.1128/JB.00333-17.

Muangpat, P., Yooyangket, T., Fukruksa, C., Suwannaroj, M., Yimthin, T., Sitthisak, S., Chantratita, N., Vitta, A., Tobias, N. J., Bode, H. B. and Thanwisai, A. (2017)
Screening of the antimicrobial activity against drug resistant bacteria of Photorhabdus and Xenorhabdus ssociated with entomopathogenic nematodes from Mae Wong National Park, Thailand. Front. Microbiol. 8, 1142. doi: 10.3389/fmicb.2017.01142.

Hirschmann, M., Grundmann, F. and Bode, H. B. (2017)
Identification and occurrence of the hydroxamate siderophores aerobactin, putrebactin, avaroferrin and ochrobactin C as virulence factors from entomopathogenic bacteria. Environ. Microbiol. 19, 4080-4090. doi: 10.1111/1462-2920.13845.

Engel, Y., Windhorst, C., Lu, X., Goodrich-Blair, H., Bode, H. B. (2017)
The global regulators Lrp, LeuO, and HexA control secondary metabolism in entomopathogenic bacteria. Front. Microbiol. 8, 209. doi: 10.3389/fmicb.2017.00209.

Heinrich, A. K., Hirschmann, M., Neubacher, N. and Bode, H. B. (2017)
LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis in Photorhabdus and Xenorhabdus. Peer. J. 5: e3471. doi: 10.7717/peerj.3471.

Cai, X., Shi, Y.-M., Pöhlmann, N., Revermann, O., Bahner, I., Pidot, S. J., Wesche, F., Lackner, H., Büchel, C., Kaiser, M., Richter, C., Schwalbe, H., Stinear, T. P., Zeeck, A. and Bode, H. B. (2017)
Structure and biosynthesis of isatropolones, bioactive amine scavenging fluorescent natural products from Streptomyces Gö66. Angew. Chem. Int. Ed. 56, 4945-4949. doi: 10.1002/anie.201701223.

Pollmann, H., Breitenbach, J., Wolff, H., Bode, H. B. and Sandmann, G. (2017)
Combinatorial biosynthesis of novel multi-hydroxy carotenoids in the red yeast Xanthophyllomyces dendrorhous. J. Fungi 3 (1), 9. doi: 10.3390/jof3010009.

Wesche, F., He, Y. and Bode, H. B. (2017)
Solid-Phase Enrichment and Analysis of Electrophilic Natural Products. Beilstein. J. Org. Chem. 13, 405-409. doi: 10.3762/bjoc.13.43.

Cai, X., Challinor, V. L., Zhao, L., Reimer, D., Adihou, H., Grün, P., Kaiser, M., Bode, H. B. (2017)
Biosynthesis of the antibiotic nematophin and ist elongated derivatives in entomopathogenic bacteria. Org. Lett., 19, 806-809. doi: 10.1021/acs.orglett.6b03796.

Kämpfer, P., Tobias, N. J., Ke, L. P., Bode, H. B. and Glaeser, S.P. (2017)
Xenorhabdus thuongxuanensis sp. nov. and Xenorhabdus eapokensis sp. nov. Isolated from Steinernema species. Int. J. Syst. Evol. Microbiol. 67, 1107-1114. doi: 10.1099/ijsem.0.001770.

Glaeser, S. P., Tobias, N. J., Thanwisai, A., Chantratita, N., Bode, H. B. and Kämpfer, P. (2017)
Photorhabdus luminescens subsp. namnaoensis subsp. nov., isolated from Heterorhabditis baujardi nematodes in Nam Nao district of central Thailand. Int. J. Syst. Evol. Microbiol. 67, 1046-1051. doi: 10.1099/ijsem.0.001761.

Cai, X., Nowak, S., Wesche, F., Bischoff, I., Kaiser, M., Fürst, R. and Bode, H. B. (2017)
Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nat. Chem. 9 (4), 379-386. doi: 10.1038/nchem.2671.

Tobias, N. J., Heinrich, A. K., Eresmann, H., Wright, P. R., Neubacher, N., Backofen, R. and Bode, H. B. (2017)
Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation of secondary metabolites, Environ. Microbiol. 19, 119-129. doi: 10.1111/1462-2920.13502.

 

2016

Heinrich, A. K., Glaeser, A., Tobias, N. J., Heermann, R. and Bode, H. B. (2016)
Heterogeneous regulation of bacterial natural product biosynthesis via a novel transcription factor. Heliyon, 2: e00197. doi: 10.1016/j.heliyon.2016.e00197.

Tobias, N. J., Ahrendt, T., Schell, U., Miltenberger, M., Hilbi, H. and Bode, H. B. (2016)
Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase. PeerJ., 4:e2720. doi: 10.7717/peerj.2720.

Orozco, R.A., Molnár, I., Bode, H. B. and Stock, S. P. (2016)
Bioprospecting for secondary metabolites in the entomopathogenic bacterium Photorhabdus luminescens subsp. Sonorensis. J. Invertebr. Pathol., 141, 45-52. doi: 10.1016/j.jip.2016.09.008.

Haack, F. S., Poehlein, A., Kröger, C., Voigt, C. A., Piepenbring, M., Bode, H. B., Daniel, R., Schäfer, W. and Streit, W. R. (2016)
Molecular keys to the Janthinobacterium and Duganella spp. interaction with the plant pathogen Fusarium graminearum, Front. Microbiol. 7, 1668. doi: 10.3389/fmicb.2016.01668.

Tobias, N. J., Mishra, B., Gupta, D. K., Sharma, R., Thines, M., Stinear, T. P. and Bode, H. B. (2016)
Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle, BMC Genomics, 17, 537. doi:10.1186/s12864-016-2862-4.

Hennicke, F., Cheikh-Ali, Z., Liebisch, T., Maciá-Vicente, J. G., Bode, H. B., Piepenbring, M. (2016)
Distinguishing commercially grown Ganoderma lucidum from Ganoderma lingzhi from Europe and East Asia on the basis of morphology, molecular phylogeny, and triterpenic acid profiles, Phytochemistry, 127, 29-37. doi: 10.1016/j.phytochem.2016.03.012.

Schimming, O., Schmitt, I. and Bode, H. B. (2016)
Identification of the Sfp-type PPTase EppA from the lichenized fungus Evernia prunastri, PLoS One, 11, e0145624. doi: 10.1371/journal.pone.0145624.

Ahrendt, T., Dauth, C., Bode, H. B. (2016)
An iso-15:0 O-alkylglycerol moiety is the key structure of the E-signal in Myxococcus xanthus. Microbiology, 162, 138-144. doi: 10.1099/mic.0.000169.

Schöner, T. A., Gassel, S., Osawa, A., Tobias, N.J., Okuno, Y., Sakakibara, Y., Shindo, K., Sandmann, G. and Bode, H.B. (2016)
Aryl Polyenes, a Highly Abundant Class of Bacterial Natural Products, Are Functionally Related to Antioxidative Carotenoids, Chem. Bio. Chem., 17, 247-253. doi: 10.1002/cbic.201500474.

Barka, F., Angstenberger, M., Ahrendt, T., Lorenzen, W., Bode, H. B. and Büchel, C. (2016)
Identification of a triacylglycerol lipase in the diatom Phaedactylum tricornutum. Biochim. Biophys. Acta., 1861, 239-248. doi: 10.1016/j.bbalip.2015.12.023.

Peréz, A. J., Wesche, F., Adihou, H. and Bode, H. B. (2016)
Solid phase enrichment and analysis of azide labelled natural products – fishing downstream of biological pathways. Chem. Eur. J., 22 (2), 639-645. doi: 10.1002/chem.201503781.

 

2015

Challinor, V. L. and Bode, H. B. (2015)
Bioactive natural products from novel microbial sources. Ann. N. Y. Acad. Sci. 1354, 82-97. doi: 10.1111/nyas.12954.

Bode, H. B. (2015)
The microbes inside us and the race for colibactin. Angew. Chem Int. Ed. 54, 10408-10411. doi: 10.1002/anie.201505341. doi: 10.1371/journal.pone.0144937.

Mulley, G., Beeton, M. L., Wilkinson, P., Vlisidou, I., Ockendon-Powell, N., Hapeshi, A., Tobias, N. J., Nollmann, F. I., Bode, H. B., van den Elsen, J., Ffrench-Constant, R. H. and Waterfield, N. R. (2015)
From insect to man: Photorhabdus sheds light on the emergence of human pathogenicity. PLoS One, 10 (12), e0144937. doi: 10.1371/journal.pone.0144937.

Schimming, O., Challinor, V. L., Tobias, N. J., Adihou, H., Grün, P., Pöschel, L., Richter, C., Schwalbe, H. and Bode, H. B. (2015)
Structure, biosynthesis, and occurrence of bacterial pyrrolizidine alkaloids. Angew. Chem. Int. Ed. 54 (43), 12702-12705. doi: 10.1002/anie.201504877.

Sharma, R., Xia, X., Cano, L. M., Evangelisti, E., Kemen, E., Judelson, H., Oome, S., Sambles, C., van den Hoogen, D. J., Kitner, M., Klein, J., Meijer, H. J., Spring, O., Win, J., Zipper, R., Bode, H. B., Govers, F., Kamoun, S., Schornack, S., Studholme, D. J., Van den Ackerveken, G. and Thines, M. (2015)
Genome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthora. BMC Genomics 16, 741.

Kresovic, D., Schempp, F., Cheikh-Ali, Z. and Bode, H. B. (2015)
A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis. Beilstein J. Org. Chem. 11, 1412-1427.

Cheikh-Ali, Z., Glynou, K., Ali, T., Ploch, S., Kaiser, M., Thines, M., Bode, H. B. and Maciá-Vicente, J.G. (2015)
Diversity of exophillic acid derivatives in strains of an endophytic Exophiala sp. Phytochemistry, 118, 83-93.

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., de Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M., Haines, A. S., Helfrich, E. J., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., van der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. and Glöckner, F. O. (2015)
Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 11, 625-631.

Schöner , T. A., Kresovic, D. and Bode, H. B. (2015)
Biosynthesis and function of bacterial dialkylresorcinol compounds. Appl. Microbiol. Biotechnol. 99, 8323-8328.

Brameyer, S., Bode, H. B. and Heermann, R. (2015)
Languages and dialects: bacterial communication beyond homoserine lactones. Trends Microbiol. 23, 521-523.

Ahrendt, T., Wolff, H., Bode, H. B. (2015)
Neutral and Phospholipids of the Myxococcus xanthus Lipodome during Fruiting Body Formation and Germination. Appl. Environ. Microbiol. 81, 6538-6547.

Bode, H. B. , Brachmann, A. O., Jadhav, K. B., Seyfarth, L., Dauth, C., Fuchs, S. W., Kaiser, M., Waterfield, N. R., Sack, H., Heinemann, S. H. and Arndt, H.-D. (2015)
Structure Elucidation and Activity of Kolossin A, the D-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase. Angew. Chem. Int. Ed. 54, 10352-10355 (selected as Hot-Paper).

Perez, A. J. and Bode, H. B. (2015)
 “Click Chemistry” for the simple determination of fatty-acid uptake and degradation: Revising the role of fatty-acid transporters, Chem. Bio. Chem. 16, 1588-1591.

Tobias, N. J., Mishra, B., Gupta, D. K., Phan Ke, L., Thines, M. and Bode, H. B. (2015)
Draft Genome Sequence of Ochrobactrum anthropi Strain ML7 Isolated from Soil Samples in Vinhphuc Province, Vietnam, Genome Announc. 3, e00218-15.

Bode, E., Brachmann, A. O., Kegler, C., Simsek, R., Dauth, C., Zhou, Q., Kaiser, M., Klemmt, P. and Bode, H. B. (2015)
Simple “on-demand” production of bioactive natural products, Chem. Bio. Chem. 16, 1115-1119.

Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y. Y., Phan Ke, L.,  Ke, Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., Vilcinskas, A., Stelzer, E., Goodrich-Blair, H., Hammock, B. D., and Bode, H. B. (2015)
A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. Chem. Bio. Chem. 16, 766-771.

Brameyer, S., Kresovic, D., Bode, H. B. and Heermann, R. (2015)
Dialkylresorcinols as bacterial signalling molecules, Proc. Natl. Acad. Sci. USA 112, 572-577.

Nollmann, F. I., Dauth, C., Mulley, G., Kegler, C., Kaiser, M., Waterfield, N. R. and Bode, H. B. (2015)
Insect-specific production of new GameXPeptides in Photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria. Chem. Bio. Chem. 16, 205-208.

Schuchmann, K., Schmidt, S., Martinez Lopez, A., Kaberline, C., Kuhns, M., Lorenzen, W., Bode, H. B., Joos, F. and Müller, V. (2015)
Nonacetogenic growth of the acetogen Acetobacter woodii on 1,2-propanediol, J. Bacteriol. 197, 382-391.

 

2014

Reimer, D. and Bode, H. B. (2014)
A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides. J. Nat. Prod. 31, 154-159.

Brameyer, S., Kresovic, D., Bode, H. B. and Heermann, R. (2014)
LuxR solos in Photorhabdus species, Front. Cell. Infect. Microbiol. 4, 166. doi: 10.3389/fcimb.2014.00166.

Kronenwerth, M., Bozhüyük, K. A. J., Kahnt, A. S., Steinhilber, D., Gaudriault, S., Kaiser, M. and Bode, H. B. (2014)
Characterisation of taxlllaids A-G; natural products from Xenorhabdus indica, Chem. Eur. J. 20, 17478-17487.

Lorenzen, W., Bozhüyük,, K. A. J., Cortina, N. S. and Bode, H. B. (2014)
A comprehensive insight into the lipid composition of Myxococcus xanthus by UPLC-ESI-MS. J. Lipid Res. 55, 2620-2633.

Morinaka, B. I., Vagstad, A. L., Helf, M. J., Gugger, M., Kegler, C., Freeman, M. F., Bode, H. B. and Piel, J. (2014)
Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products. Angew. Chem. Int. Ed. 53, 8503-8507.

Kronenwerth, M., Dauth, C., Kaiser, M., Pemberton, I. and Bode, H. B. (2014)
Facile synthesis of cyclohexanediones and dialkylresorcinols: bioactive natural products from entomopathogenic bacteria. Eur. J. Org. Chem. 8026-8028.

Kronenwerth, M., Brachmann, A. O., Kaiser, M. and Bode, H. B. (2014)
Bioactive Derivatives of isopropylstilbenes from mutasynthesis and chemical synthesis. Chem. Bio. Chem. 15, 2689-2691.

Reimer, D., Nollmann, F. I., Schultz, K., Kaiser, M. and Bode, H. B. (2014)
Xenortide biosynthesis by entomopathogenic Xenorhabdus nematophila. J. Nat. Prod. 77, 1976-1980.

Perez, A. J. and Bode, H. B. (2014)
w-Azido fatty acids as probes to detect fatty acid biosynthesis, degradation and modification. J. Lipid Res. 55, 1897-1901.

Lorenzen, W., Ahrendt, T., Bozhüyük, K. A. J. and Bode, H. B. (2014)
A multifunctional enzyme is involved in bacterial ether lipid biosynthesis. Nat. Chem. Biol. 10, 425-427.

Schimming, O., Fleischhacker, F., Nollmann, F. I. and Bode, H. B. (2014)
Yeast homologous recombination cloning leading to the novel peptides ambactin and xenolindicin. Chem. Bio. Chem. 15, 1290-1294.

Grundmann, F., Kaiser, M., Schiell, M., Kurz, M., Thanwisai, A., Chantratita, N. and Bode, H. B. (2014)
Antiparasitic Chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4, J. Nat. Prod. 77, 779-783.

Schild, H.-A., Fuchs, S. W., Bode, H. B. and Grünewald, B. (2014)
Low-molecular weight metabolites secreted by Paenibacillus larvae as potential virulence factors of American Foulbrood. Appl. Environ. Microbiol., 80, 2484-2492.

Kegler, D., Nollmann, F. I., Ahrendt, T., Fleischhacker, F., Bode, E. and Bode, H. B. (2014)
Rapid determination of the amino acid configuration of xenotetrapeptide. Chem. Bio. Chem. 15, 826-828.

Schöner, T. A., Fuchs, S. W., Reinhold-Hurek, B. and Bode, H. B. (2014)
Identification and biosynthesis of a novel xanthomonadin-dialkylresorcinol-hybrid from Azoarcus sp. BH72. PLoS ONE 9 (3), e90922.

Fuchs, S. W., Grundmann, F., Kurz, M., Kaiser, M. & Bode, H. B. (2014)
Fabclavines: bioactive peptide-polyketide-polyamino hybrids from Xenorhabdus, Chem. Bio. Chem. 15, 512-516.

Bhat, S., Ahrendt, T., Dauth, C., Bode, H. B. & Shimkets, L. J. (2014)
Two Lipid Signals Guide Fruiting Body Development of Myxococcus xanthus. mBIO 5 (1): e00939-13.

Schöner, T. A., Fuchs, S. W., Schönau, C. & Bode, H. B. (2014)
Initiation of the flexirubin biosynthesis in Chitinophaga pinensis. Microbial Biotechnol. doi: 10.1111/1751-7915.12110.

Proschak, A., Zhou, Q., Schöner, T., Thanwisai, A., Kresovic, D., Dowling, A., Ffrench-Constant, R., Proschak, E. & Bode, H. B. (2014)
Biosynthesis of the insecticidal xenocyloins in Xenorhabdus bovienii, Chem. Bio. Chem. 15, 369-372.

 

2013

Brachmann, A. O. & Bode, H. B. (2013)
Identification and bioanalysis of natural products from insect symbionts and pathogens. (Chapter 2.3) in: Adv. Biochem. Eng. Biotechnol. Vilcinskas, A. (Ed.). Yellow Biotechnology, Springer, 135, 123-155.

Lango-Scholey, L., Brachmann, A. O., Bode, H. B. & Clarke, D. (2013)
The expression of stlA in Photorhabdus luminescens is controlled by nutrient limitation. PLoS ONE 8: e82152.

Zhou, Q., Grundmann, F., Kaiser, M., Schiell, M., Gaudriault, S., Batzer, A., Kurz, M. & Bode, H. B. (2013)
Structure and biosynthesis of xenoamicines from entomopathogenic Xenohabdus. Chem. Eur. J. 19, 16772-16779.

Grundmann, F., Kaiser, M., Kurz, M., Schiell, M., Batzer, A. & Bode, H. B. (2013)
Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3. RSC Advance 3, 22072-22077.

Reimer, D., Cowles, K. N., Proschak, A., Nollmann, F. I., Dowling, A. J., Kaiser, M., Ffrench-Constant, R., Goodrich-Blair, H. & Bode, H. B. (2013)
Rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria. Chem. Bio. Chem. 14, 1991-1997.

Brachmann, A. O., Brameyer, S., Kresovic, D., Hiltkova, I., Kopp, Y., Manske, C., Schubert, K., Bode, H. B. & Heermann, R. (2013)
Pyrones as bacterial signaling molecules. Nat. Chem. Biol. 9, 573-578.

Ahrendt, T., Miltenberger, M., Haneburger, I., Kirchner, F., Kronenwerth, M., Brachmann, A.-O., Hilbi, H. & Bode, H. B. (2013)
Biosynthesis of the natural fluorophore legioliulin from Legionella. Chem. Bio. Chem. 14, 1415-1418.

Sahm, F., Oezen, I., Opitz, C. A., Radlwimmer, B., von Deimling, A., Ahrendt, T., Adams, S., Bode, H. B., Giullemin, G. J., Wick, W. & Platten, M. (2013)
The endogenous tryptophan metabolite and NAD+ precursor Quinolinic acid confers resistance of gliomas to oxidative stress, Cancer Res. 73, 3225-3234.

Proschak, A., Lubuta, P., Grün, P., Löhr, F., Wilharm, G., De Berardinis, V. & Bode, H. B. (2013)
Structure and biosynthesis of fimsbactins A-F, siderophores from Acinetobacter baumannii and Acinetobacter baylyi. Chem. Bio. chem. 14, 633-8.

Fuchs, S.W., Bozhüyük, K. A. J., Kresovic, D., Grundmann, F., Dill, V., Brachmann, A. O., Waterfield, N.R. & Bode, H. B. (2013)
Formation of 1,3-Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase. Angew. Chem. Int. Ed. 52, 4108-4112.

Buscató, E., Büttner, D., Brüggerhoff, A., Klingler, F.-M., Weber, J., Scholz, B., Živković, A., Marschalek, R., Stark, H., Steinhilber, D., Bode, H. B. & Proschak, E. (2013)
From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties. Chem. Med. Chem. 8, 919-923.

Hornung, C., Poehlein, A., Haack, F. S., Schmidt, M., Dierking, K., Pohlen, A., Schulenburg, H., Blokesch, M., Plener, L., Jung, L., Bonge, A., Krohn-Molt, I., Utpatel, C., Timmermann, G., Spieck, E., Pommerening-Röser, A., Bode, E., Bode, H. B., Daniel, R., Schmeisser, C., & Streit, W. R. (2013)
The Janthinobacterium sp. HH01 genome encodes a homologue of the V. cholerae CqsA and L. pneumophila LqsA autoinducer synthases. PLoS ONE 8(2):e55045.

 

2012

Zhou, Q., Dowling, A., Heide, H., Wöhnert, J., Brandt, U., Baum, J., Ffrench-Constant, R. & Bode, H. B. (2012)
Xentrivalpeptides A-Q: Depsipeptide diversification in Xenorhabdus. J. Nat. Prod. 75, 1717-1722.

Brat, D., Weber, C., Lorenzen, W., Bode, H. B. & Boles, E. (2012)
Cytosolic re-localization and optimization of valine synthesis and catabolism enables increased isobutanol production with the yeast Saccharomyces cerevisiae. Biotechnol. Biofuels 5, 65.

Brachmann, A. O., Reimer, D., Lorenzen, W., Augusto Alonso, E., Kopp, Y., Piel, J. & Bode, H. B. (2012)
Reciprocal crosstalk between fatty acid and antibiotic biosynthesis in a nematode symbiont, Angew. Chem. Int. Ed. 51, 12086-12089.

Hilbers, F., van Wonderen, J., Lorenzen, W., Bode, H. B., MacMillan, F., Ludwig, B. & Michel, H. (2012)
The catalase activity of the aa3 cytochrome c oxidase from Paracoccus denitrificans. Biochim. Biophys. Acta (BBA) – Bioenergetics 187, 108.

Thanwisai, A., Tandhavanant, S., Saiprom, N., Waterfield, N. R., Phan Ke, L., Bode, H. B., Peacock, S. J., Chantratita, N. (2012)
Diversity of Xenorhabdus and Photorhabdus spp. and their symbiotic entomopathogenic nematodes from Thailand, PLoS ONE 7, e43835.

Fuchs, S. W., Sachs, C. C., Kegler, C., Nollmann, F. I., Karas, M. & Bode, H. B. (2012)
Neutral loss fragmentation pattern based screening for arginine-rich natural products in Xenorhabdus and Photorhabdus, Anal. Chem. 84, 6948-6955.

Grundmann, F., Dill, V., Dowling, A., Thanwisai, A., Bode, E., Chantratita, N., Ffrench-Constant, R. & Bode, H. B. (2012)
Identification and isolation of insecticidal oxazoles from Pseudomonas sp., Beilstein J. Org. Chem. 8, 749-752.

Nollmann, F. I., Dowling, A., Kaiser, M., Deckmann, K., Grösch, S., Ffrench-Constant, R. & Bode, H. B. (2012)
Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum, Beilstein J. Org. Chem. 8, 528-533.

Bode, H. B., Reimer, D., Fuchs, S. W., Kirchner, F., Dauth, C., Kegler, D., Lorenzen, W., Brachmann, A. O. & Grün, P. (2012)
Determination of the absolute configuration of peptide natural products using stable isotope labeling and mass spectrometry, Chem. Eur. J. 18, 2342-2348.

Brachmann, A. O., Kirchner, F., Kegler, C., Kinski, S. W., Schmitt, I. & Bode, H. B. (2012)
Triggering the production of the cryptic blue pigment indigoidine from Photorhabdus luminescens. J. Biotechnol. 157, 96-99.

 

2011

Chaston, J.M., Suen, G., Tucker, S.L., Andersen, A. W., Bhasin, A., Bode, E., Bode, H. B., Brachmann, A. O., Cowles, C. E., Cowles, K. N., Darby, C., de Léon, L., Drace, K., Du, Z., Givaudan, A., Herbert Tran, E. E., Jewell, K. A., Knack, J. J., Krasomil-Osterfeld, K. C., Kukor, R., Lanois, A., Latreille, P., Leimgruber, N. K., Lipke, C. M., Liu, R., Lu, X., Martens, E. C., Marri, P. R., Médigue, C., Menard, M. L., Miller, N. M., Morales-Soto, N., Norton, S., Ogier, J.-C., Orchard, S. S., Park, D., Park, Y., Qurollo, B. A., Renneckar Sugar, D., Richards, G. R., Rouy, Z., Slominski, B., Slominski, K., Snyder, H., Tjaden, B. C., van der Hoeven, R., Welch, R. D., Wheeler, C., Xiang, B., Barbazuk, B., Gaudriault, S., Goodner, B., Slater, S. C., Forst, S., Goldman. B. S. & Goodrich-Blair, H. (2011)
The Entomopathogenic Bacterial Endosymbionts Xenorhabdus and Photorhabdus: Convergent Lifestyles from Divergent Genomes, PLoS ONE 6, e27909.

Reimer, D., Pos, K. M., Thines, M., Grün, P. & Bode, H. B. (2011)
A natural prodrug activation mechanism in nonribosomal peptide synthesis. Nat. Chem. Biol. 7, 888-890.

Proschak, A., Schultz, K., Herrmann, J., Dowling, A. J., Brachmann, A. O., Ffrench-Constant, R., Müller, R. & Bode, H. B. (2011)
Cytotoxic fatty acid amides from Xenorhabdus. Chem. Bio. Chem. 12, 2011-2015.

Kopp, M., Irschik, H., Gemperlein, K., Buntin, K., Meiser, P., Weissman, K. J., Bode, H. B. & Müller, R. (2011)
Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690. Mol. Biosyst. 7, 1549-1563.

Fuchs, S. W., Proschak, A., Jaskolla, T. W., Karas, M. & Bode, H. B. (2011)
Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila. Org. Biomol. Chem. 9, 3130-3132.

 

2010

Bode, H. B. (2010)
Insect-Associated Microorganisms as a Source for Novel Secondary Metabolites with Therapeutic Potential (Chapter 5) in: Vilcinskas, A. (Ed.) Insect Biotechnology, Springer, 77-93.

 

2009

Bode, H. B. (2009)
Entomopathogenic bacteria as source of new secondary metabolites, Curr. Opin. Chem. Biol. 13, 224-230.

Bode, H. B. (2009)
Insects: True pioneers in anti-infective therapy and what we can learn from them, Angew. Chem. Int. Ed. 48, 6394-6396.

Hoiczyk, E., Ring, M. W., McHugh, C. A., Schwär, G., Bode, E., Krug, D., Altmeyer, M. O., Lu, J. Z. & Bode, H. B. (2009)
Lipid body formation plays a critical role in cell fate determination during developmental differentiation of Myxococcus xanthus. Mol. Microbiol. 74, 497-517.

Park, D., Ciezki, K., van der Hoeven, R., Singh, S., Reimer, D., Bode, H. B. & Forst, S. (2009)
Genetic analysis of xenocoumacin antibiotic production in the mutualistic bacterium Xenorhabdus nematophila, Mol. Microbiol. 73, 938-949.

Reimer, D., Luxenburger, E., Brachmann, A. O. & Bode, H. B. (2009)
A new type of pyrrolidine biosynthesis is involved in the late steps of xenocoumacin production in Xenorhabdus nematophila, Chem. Bio. Chem. 10, 1997-2010.

Lorenzen, W., Schwär, G., Müller, R. & Bode, H. B. (2009)
Isoprenoids are required for fruiting body formation in M. xanthus, J. Bacteriol. 91, 5849-5853.

Ring, M.W., Schwär, G. & Bode, H. B. (2009)
Biosynthesis of 2‑hydroxy and iso‑even fatty acids is connected to sphingolipid formation in myxobacteria, Chem. Bio. Chem. 10, 2003-2010.

Ring, M.W., Bode, E., Schwär, G. & Bode, H. B. (2009)
Functional analysis of desaturases from the myxobacterium Myxococcus xanthus, FEMS Microbiol. Lett. 296, 124-130.

Zöllner, A., Dragan, C.A., Pistorius, D., Müller, R. & Bode, H. B., Peters, F.T., Maurer, H.H. & Bureik, M. (2009)
Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid, Biol. Chem. 390, 313-317.

Ohlendorf, B., Lorenzen, W., Kehraus, S., Krick, A., Bode, H. B. & König, G. M. (2009)
Myxotyrosides A and B, unusual Rhamnosides from Myxococcus sp. J. Nat. Prod. 72, 82-86.

Bode, H. B., Ring, M. W., Schwär, G., Altmeyer, M. O., Kegler, C., Jose, I. R., Singer, M. & Müller, R. (2009)
Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium M. xanthus. Chem. Bio. Chem. 10, 128-140.

 

2008

Waterfield, N. R., Sanchez-Contreras, M., Eleftherianos, I., Dowling, A., Wilkinson, P., Parkhill, J., Thomson, N., Reynolds, S. E., Bode, H. B., Dorus, S. & Ffrench-Constant, R. H. (2008)
Rapid Virulence Annotation (RVA): Identification of virulence factors using a bacterial genome library and multiple invertebrate hosts. Proc. Natl. Acad. Sci. USA 105, 15967-15972.

Wenzel, S. C., Bode, H. B., Kochems, I. & Müller, R. (2008)
A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin. Chem. Bio. Chem. 9, 2711-2721.

Meiser, P., Weissman, K. J., Bode, H. B., Dickschat, J. S., Sandmann, A. & Müller, R. (2008)
DKxanthene biosynthesis – Understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism. Chem. Biol. 15, 771-781.

Joyce, S. A., Brachmann, A. O., Glazer, I., Lango, L., Schwär, G., Clarke, D. J. & Bode, H. B. (2008)
Bacterial biosynthesis of a multipotent stilbene. Angew. Chem. Int. Ed., 47, 1942-1945 (selected as VIP-Paper).

 

2007

Bode, H. B. & Müller, R. (2007)
Secondary metabolism in Myxobacteria (Chapter 15) in: Whitworth, D. (Ed) Myxobacteria: multicellularity and differentiation. ASM press, Chicago.

Bode, H. B. & Müller, R. (2007)
Reversible sugar transfer by glycosyltransferases as a tool for natural product (bio)synthesis. Angew. Chem. Int. Ed. 46, 2147-2150.

Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel,  T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M., Meyer, F., Mormann, S., Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., Vorhölter, F. J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A. & Müller, R. (2007)
Complete sequence of the largest known bacterial genome from the myxobacterium Sorangium cellulosum. Nature Biotechnol. 25, 1281-1289.

Frank, B., Wenzel, S. C., Bode, H. B., Scharfe, M., Blöcker, H. & Müller, R. (2007)
From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes, J. Mol. Biol. 374, 24-38.

Bode, H. B., Meiser, P., Klefisch, T., Socorro d. J. Cortina, N., Krug, D., Göhring, A., Schwär, G., Mahmud, T., Elnakady, Y. A. & Müller, R. (2007)
Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B. Chem. Bio. Chem. 8, 2139-2144.

Latreille, P., Norton, S., Goldman, B. S., Henkhaus, J., Miller, N., Barbazuk, B.,  Bode, H. B., Darby, C., Du, Z., Forst, S., Gaudriault, S., Goodner, B., Goodrich-Blair, H. & Slater, S. (2007)
Optical Mapping as a Routine Tool for Bacterial Genome Sequence Finishing, BMC Genomics 8, 321.

Brachmann, A. O., Joyce, S. A., Jenke-Kodama, H., Schwär, G., Clarke, D. J. & Bode, H. B. (2007)
A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens. Chem. Bio. Chem. 8, 1721-1728.

 

2006

Bode, H.B. & Müller, R. (2006)
Analysis of myxobacterial secondary metabolism goes molecular, J. Ind. Biotechnol. Microbiol. 33, 577-588.

Brachmann, A.O., Forst, S., Furgani, G.M., Fodor, A. & Bode, H.B. (2006)
Xenofuranones A and B: Phenylpyruvate dimers from Xenorhabdus szentirmaii, J. Nat. Prod. 69, 1830-1832.

Meiser, P., Bode, H. B. & Müller, R. (2006)
The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation. Proc. Natl. Acad. Sci. USA 103,
19128-33.

Ring, M. W., Schwär, G., Thiel, V., Dickschat, J. S., Kroppenstedt, R. M., Schulz, S. & Bode, H. B. (2006)
Novel iso-branched etherlipids as specific markers of developmental sporulation in the myxobacterium Myxococcus xanthus. J. Biol. Chem. 281, 36691-36700.

Bode, H. B., Ring, M. W., Schwär, G., Kroppenstedt, R. M., Kaiser, D. & Müller, R. (2006)
3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in the biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation. J. Bacteriol. 188, 6524-6528.

Bode, H. B., Ring, M. W., Kaiser, D., David, A. C., Kroppenstedt, R. M. & Schwär, G. (2006)
Straight-chain fatty acids are dispensable in the myxobacterium Myxococcus xanthus. J. Bacteriol. 188, 5632-5634.

 

2005

Bode, H. B. & Müller, R. (2005)
The impact of bacterial genomics on natural product research, Angew. Chem. Int. Ed. 44, 6828-6846.

Dickschat, J. S., Bode, H. B., Mahmud, T., Müller, R. & Schulz, S. (2005)
A novel type of Geosmin biosynthesis in myxobacteria. J. Org. Chem. 70, 5174-82.

Dickschat, J. S., Bode, H. B., Kroppenstedt, R. M., Müller, R. & Schulz, S. (2005)
Biosynthesis of iso-fatty acids in myxobacteria. Org. Biomol. Chem. 3, 2824-31.

Dickschat, J. S., Bode, H. B., Wenzel, S. C., Müller, R. & Schulz, S. (2005)
Biosynthesis and Identification of Volatiles Released by the Myxobacterium Stigmatella aurantiaca. Chem. Bio. Chem. 6, 2023-2033.

Bode, H. B., Dickschat, J. S., Kroppenstedt, R. M., Schulz, S. & Müller, R. (2005)
Biosynthesis of iso-fatty acids in myxobacteria: iso-even fatty acids are derived from a-oxidation of iso-odd fatty acids. J. Am. Chem. Soc. 127, 532-533.

Mahmud, T., Wenzel, S. C., Wan, E., Wen, K. W., Bode, H. B., Gaitatzis, N. & Müller, R. (2005)
A Novel Biosynthetic Pathway to Isovaleryl-CoA in Myxobacteria: The Involvement of the Mevalonate Pathway. Chem. Bio. Chem. 6, 322-330.

 

2004

Wenzel, S. C. & Bode, H. B. (2004)
Novel polyene carboxylic acids from Streptomyces. J. Nat. Prod. 67, 1631-1633.

Bode, H.B., Wenzel, S. C., Irschik, H., Höfle, G. & Müller, R. (2004)
An unusual biosynthesis leading to the unique leupyrrin class of natural products in the myxobacterium Sorangium cellulosum. Angew. Chem. Int. Ed. Engl. 43, 4163-4167.

Dickschat, J.S., Wenzel, S.C., Bode, H. B., Mahmud, T., Müller, R. & Schulz, S. (2004)
Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chem. Bio. Chem. 5, 778-787.

 

2003

Bode, H. B. & Müller, R. (2003)
Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites. Plant Physiol. 132, 1153-1161.

Bode, H. B., Irschik, H., Wenzel, S. C., Reichenbach, H., Müller, R. & Höfle, G. (2003)
The Leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum. J. Nat. Prod. 66, 1203-1206.

Bode, H. B., Zeggel, B., Silakowski, B., Wenzel, S. C., Reichenbach, H. & Müller, R. (2003)
Steroid biosynthesis in prokaryotes: Identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Mol. Microbiol. 47, 471-481.

Busch, S., Bode, H. B., Brakhage, A. A. & Braus, G. H. (2003)
Impact of the cross-pathway control on the metabolic flux towards lysine and penicillin in Aspergillus nidulans. Curr. Genetics 42, 209-219.

 

2002

Bode, H. B., Höfs, R., Bethe, B. & Zeeck, A. (2002)
Big effects from small changes: possible ways to explore nature´s chemical diversity. Chem. Bio. Chem. 3, 619-627.

 

Mahmud, T., Bode, H. B., Silakowski, B., Kroppenstedt, R. M., Xu, M., Nordhoff, S., Höfle, G. & Müller, R. (2002)
A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria. J. Biol. Chem. 277, 32768-32774.

 

2001

Bode, H. B., Kerkhoff, K. & Jendrossek, D. (2001)
Bacterial degradation of natural and synthetic rubber. Biomacromolecules 2, 295-303.

 

2000

Bode, H. B., Zeeck, A., Plückhahn, K. & Jendrossek, D. (2000)
Physiological and chemical investigations into microbial degradation of synthetic poly(cis-1,4-isoprene). Appl. Environ. Microbiol. 66, 3680-3685.

Bode, H. B. & Zeeck, A. (2000)
Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces. J. Chem. Soc., Perkin Trans. 1, 323-328.

Bode, H. B. & Zeeck, A. (2000)
Biosynthesis of kendomycin: Origin of the oxygen atoms and further investigations, J. Chem. Soc., Perkin Trans. 1, 2665-2670.

Bode, H. B., Wegner, B. & Zeeck, A. (2000)
Biosynthesis of cladospirone bisepoxide, a member of the spirobisnaphthalene family.
J. Antibiotics 53, 153-157.

Bode, H. B. & Zeeck, A. (2000)
Sphaerolone and dihydrosphaerolone, two bisnaphthyl-pigments from the fungus Sphaeropsidales sp. F-24´707. Phytochemistry 54, 597-601.

Bode, H. B. & Zeeck, A. (2000)
UV mutagenesis and enzyme inhibitors as tools to elucidate the late biosynthesis of the spirobisnaphthalenes. Phytochemistry 55, 311-316.

Bode, H. B., Walker, M. & Zeeck, A. (2000)
Structure and biosynthesis of mutolide, a novel macrolide from a UV mutant of the fungus F-24´707. Eur. J. Org. Chem. 1451-1456.

Bode, H. B., Walker, M. & Zeeck, A. (2000)
Cladospirones B to I from Sphaeropsidales sp. F-24´707 by variation of culture conditions. Eur. J. Org. Chem. 3185-3193.

 

Additional publications (not peer-reviewed)

Shi, Y.-M. and Bode, H. B. (2017)
A new language for small talk. Nat. Chem. Biol. 13, 453-454.

Nollmann, F. I., Dauth, C., Reimer, D., Zhou, Q. and Bode, H. B. (2012)
Peptides in Xenorhabdus and Photorhabdus spp., Proceedings of the 32nd European Peptide Symposium (Ed. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas), 284-285.

Bode, H. B. (2012)
Insektenpathogene Bakterien als Quelle neuer Naturstoffe in D. Jahn (Ed.) Zellbiologie und Mikrobiologie – Das Beste aus BIOspektrum, 51-55.

Bode, H. B. (2012)
Drugs from bugs that kill bugs, Microbiology Today, 216-219.

Bode, H. B. (2010)
Insektenpathogene Bakterien als Quelle neuer Naturstoffe, Biospektrum, 266-270.

Brachmann, A. O., Schwär, G. and Bode, H. B. (2008)
Photorhabdus and Xenorhabdus: potent secondary metabolite producers, IOBC/WPRS 11th European meeting “Insect pathogens and entomoparasitic nematodes”, Bulletin IOLB SROP, 31, 151-156.

Bode, H. B. (2006)
No need to be pure: mix the cultures!, Chem. Biol. 13, 1245-1246.

Bode, H. B. (2006)
Mehr als nur Naturstoffe, transkript 12, 55 (Tagungsbericht über die 18. Irseer Naturstofftage (DECHEMA) vom 22.02.-24.02.2006).

Bode, H. B. (2001)
 „Junge“ Naturstoffchemie, Nachrichten aus der Chemie 49, 951 (Tagungsbericht über die 13. Irseer Naturstofftage (DECHEMA) vom 28.02.-02.03.2001).

 

Patents

Niesert, C. P., Bode, H. B., Bozhüyük, K. A. J. and Fleischhacker, F. (2017)
Artificial non-ribosomal peptide synthetases, WO2017020983(A1).

 

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