Publications

Publications

Members of the Metabolomics Core Facility are only included in the authors list, if they contributed intellectually to a paper. In cases where we provide only standard analytical services, we kindly ask to be mentioned in the acknowledgement.


Hakobyan A, Zhu J, Glatter T, Paczia N, Liesack W. (2020)
Hydrogen utilization by Methylocystis sp. strain SC2 expands the known metabolic versatility of type IIa methanotrophs
Metab Eng. 2020 Sep;61:181-196. doi: 10.1016/j.ymben.2020.05.003. 

Burgener S, Cortina NS, Erb TJ. (2020)
Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids, Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5526-5530. doi: 10.1002/anie.201915155.

Milne-Davies B, Helbig C, Wimmi S, Cheng DWC, Paczia N & Diepold A (2019)
Life After Secretion - Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions. Frontiers in Microbiology 10:2128, doi: 10.3389/fmicb.2019.02128

Cotton CA, Bernhardsgrütter I, He H, Burgener S, Schulz L, Paczia N, Dronsella B, Erban A, Toman S, Dempfle M, De Maria A, Kopka J, Lindner SN, Erb TJ, Bar-Even A. (2020)
Underground isoleucine biosynthesis pathways in E. coli. Elife. 2020 Aug 24;9:e54207. doi: 10.7554/eLife.54207.

Miller TE, Beneyton T, Schwander T, Diehl C, Girault M, McLean R, Chotel T, Claus P, Cortina NS, Baret JC, Erb TJ. (2020)
Light-powered CO2 fixation in a chloroplast mimic with natural and synthetic parts. Science. 2020 May 8;368(6491):649-654. doi: 10.1126/science.aaz6802.

Schada von Borzyskowski L, Severi F, Krüger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ. (2019) 
Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle Nature. 2019 Nov;575(7783):500-504. doi: 10.1038/s41586-019-1748-4. Epub 2019 Nov 13. 

Schymanski E.L., Baker N.C., Williams A.J., Singh R.R., Trezzi J.P., Wilmes P., Kolber P.L., Kruger R., Paczia N., Linster C.L., Balling R. (2019)
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. Environ Sci Process Impacts. 2019 Sep 18;21(9):1426-1445. doi: 10.1039/c9em00068b.

Bernhardsgrütter I, Vögeli B, Wagner T, Peter DM, Cortina NS, Kahnt J, Bange G, Engilberge S, Girard E, Riobé F, Maury O, Shima S, Zarzycki J, Erb TJ. (2018)
The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. Nat Chem Biol. 2018 Dec;14(12):1127-1132. doi: 10.1038/s41589-018-0153-x. Epub 2018 Oct 29.

Vögeli B, Rosenthal RG, Stoffel GMM, Wagner T, Kiefer P, Cortina NS, Shima S, Erb TJ. (2018)
InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis. J Biol Chem. 2018 Nov 2;293(44):17200-17207. doi: 10.1074/jbc.RA118.005405. Epub 2018 Sep 14.

Vögeli B, Geyer K, Gerlinger PD, Benkstein S, Cortina NS, Erb TJ. (2018)
Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis. Cell Chem Biol. 2018 Jul 19;25(7):833-839.e4. doi: 10.1016/j.chembiol.2018.04.009. Epub 2018 May 3. 

Zarzycki J, Sutter M, Cortina NS, Erb TJ, Kerfeld CA. (2017)
In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment. Sci Rep. 2017 Feb 16;7:42757. doi: 10.1038/srep42757. 

Gajewski, J., Buelens, F., Serdjukow, S, Janßen, M., Cortina, N., Grubmüller, H., Grininger, M. (2017)
Engineering fatty acid synthases for directed polyketide production, Nature Chemical Biology 13, 363-365.

Zarzycki, J., Sutter, M., Cortina, N.S. Erb, T.J., Kerfeld, C. (2017)
In Vitro characterization and concerted function of three core enzymes of a glycyl radical enzyme - associated bacterial microcompartment, Scientific Reports 7, 42757.

Peter, D. M., Vogeli, B., Cortina, N. S., and Erb, T. J. (2016)
A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters, Molecules 21, 517.

Schwander, T., Schada von Borzyskowski, L., Burgener, S., Cortina, N. S., and Erb, T. J. (2016)
A synthetic pathway for the fixation of carbon dioxide in vitro, Science 354, 900-904.

Other Publications/Patents of Nicole Paczia

Paczia N and Becker-Kettern J (equal contribution), Conrotte J, Cifuente J, Guerun M, Linster C (2019)
3-Phosphoglycerate transhydrogenation instead of dehydrogenation alleviates redox state dependency of yeast Biochemistry, January 2019 Volume 58, Issue 1

Van Bergen N., Guo Y, Ranik J. and Paczia N (equal contribution) et al (2019)
NAD(P)HX Dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. Brain, Volume 142, Issue 1, 1 January 2019, Pages 50–58, https://doi.org/10.1093/brain/awy310

Veiga-da-Cunha M., Chevalier N., Stephenne X., Dufour JP., Paczia N., Ferster A., Linster C., Bommer G. and Van Schaftingen E. (2019)
Failure to eliminate a phosphorylated glucose-analog leads to neutropenia in patients with G6PT and G6PC3 deficiency PNAS published ahead of print January 9, 2019. https://doi.org/10.1073/pnas.1816143116

Becker-Kettern J, Paczia N, Conrotte J, Yhu C., Fiehn O., Jung P, Steinmets L., Linster C (2018)
NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS 11 August 2018 https://doi.org/10.1111/febs.14631ePDFPDF

Jung PP, Zhang Z, Paczia N, Jaeger C, Ignac T, May P, Linster CL. (2018)
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. NPJ Aging Mech Dis. 2018 Mar 12;4:3. doi: 10.1038/s41514-018-0022-6. eCollection 2018.

Berger E, Magliaro C, Paczia N, Monzel A, Antony P, Linster C, Bolognin S, Ahluwalia A and Schwamborn J (2018)
Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab Chip, 2018,18, 3172

Peracchi A, Veiga-da-Cunha M, Kuhara T, Ellens K, Paczia N, Stroobant V, Seliga A, Marlaire S, Jaisson S, Bommer G, Sun J, Huebner K, Linster C, Cooper A, Van Schaftingen E (2017)
„Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione” PNAS, Apr, 114(16):E3233-E3242

Becker-Kettern J and Paczia N (equal contribution), Conrotte J, Kay D, Guignard C, Jung P, Linster C (2016)
”Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase” Journal of Biological Chemistry, 291, 6036-6058.

Unthan S, Grünberger A, van Ooyen J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S (2013)
„Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium“ Biotechnology and Bioengineering, 2013 Sep, online

Paczia N, Nilgen A, Lehmann T, Gätgens J, Wiechert W, Noack S (2012) 
Extensive Exometabolome Analysis Reveals Extended Overflow Metabolism in various Microorganisms. Microbial Cell Factories, 11(1):122.

Tillack J and Paczia N (equal contribution), Katharina Nöh, Wolfgang Wiechert and Stephan Noack (2012)
Error Propagation Analysis for Quantitative Intracellular Metabolomics. Metabolites, 2(4), 1012-1030;

Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L,  Wiechert W, Noack S, Kohlheyer D (2012) 
A disposable picoliter bioreactor for cultivation and investigation of industrially relevant bacteria on single cell level.  Lab on a Chip, 12: 1060-2068  

Grünberger A, van Ooyen J, Paczia N, Rohe P, Schendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S (2012) 
"Beyond growth rate 0.6: C. glutamicum cultivated in highly diluted environments“, Biotechnology and Bioengineering, Aug, 110(1):220-8.

Oldiges M, Noack S, Paczia N (2012) 
Metabolomics in Biotechnology (microbial metabolomics) in: Lämmerhofer M, Weckwerth W (Hg.) “Metabolomics in Practice – Successful strategies to generate and analyze metabolic data” Wiley-VCH Verlag GmbH & Co.KGaA (Weinheim)

Patents

Paczia N, Jung P, Shah P, Linster C, Dimaki M, Svendson W. (2018)
Microfluidic system for yeast aging analysis. World Intellectual Property Organization, patent no. WO 2020/043786 A1

Paczia N, Schramm C, Noack S (2016)
Vorrichtung und Verfahren zur Zellseparation. Deutsches Patent- und Markenamt, patent no. 102012009088

von Lieres E, Motyll S, Paczia N (2012)
Probeentnahmevorrichtung und Verfahren zur Entnahme einer Probe aus einem Bioreaktor. Deutsches Patent- und Markenamt, patent no. 102012003113

 

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