Contact

Dr. Lennart Randau
Dr. Lennart Randau
Research Group Leader
Phone: +49 6421 178 600

Research Group Members

Dr. Alvaro Orell
Dr. Alvaro Orell
Postdoctoral Fellow
Phone: +49 6421 178 612
Michael Daume
Michael Daume
Ph.D. Student
Phone: +49 6421 178 611
Hanna Müller Esparza
Hanna Müller Esparza
Ph.D. Student
Phone: +49 6421 178 630
Ahsen Özcan
Ahsen Özcan
Phone: +49 6421 178 612
Daniel Gleditzsch
Daniel Gleditzsch
Ph.D. Student
Phone: +49 6421 178 612
Julia Wiegel
Julia Wiegel
Technical Assistant
Phone: +49 6421 178 611
Fax: +49 6421 178 599

Dr. Lennart Randau - Prokaryotic Small RNA Biology

Dr. Lennart Randau

Curriculum Vitae

Lennart Randau (born 1978)
Diplom (Biology), TU Braunschweig, Germany, 2002
Ph.D. (Dr. rer. nat.), TU Braunschweig, Germany, 2006
Post-doc, Yale University, USA, 2006 - 2010)
Head of the Max Planck Research Group "Prokaryotic Small RNA Biology" at the MPI for Terrestrial Microbiology, Marburg, since 12/2010

Research area: Prokaryotic Small RNA Biology

Our research is aimed at understanding the processing of small RNAs involved in the defense against integrative elements (e.g. viruses) in Bacteria and Archaea. First, we investigate the RNAs that play the central role in the prokaryotic CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) immune system. Second, we study the evolution of diverse disruptive elements within archaeal transfer RNA (tRNA) genes. These systems will be exploited for the modulation of prokaryotic immunity and the creation of gene knock-down technology. Our research uses an interdisciplinary approach combining computational, biochemical and microbiological techniques.
More about "Prokaryotic Small RNA Biology"
MPI homepage  

The group of Lennart Randau as per October 2015 Zoom Image
The group of Lennart Randau as per October 2015

Recent publications

Gleditzsch, D., Müller-Esparza, H., Pausch, P., Sharma, K., Dwarakanath, S., Urlaub, H., Bange, G. and Randau, L. (2016) Modulating the Cascade architecture of a minimal Type I-F CRISPR-Cas system. Nucleic Acids Res. [in press]

Plagens, A., Daume, M., Wiegel, J. and Randau, L. (2015) Circularization restores signal recognition particle RNA functionality in Thermoproteus. eLIFE, 10.7554/eLife.11623

Dwarakanath, S., Brenzinger, S., Gleditzsch, D., Plagens, A., Klingl, A., Thormann, K. and Randau, L. (2015) Interference activity of a minimal Type I CRISPR-Cas system from Shewanella putrefaciens. Nucleic Acids Res [in press].

Dennis, P., Tripp, V., Lui, L, Lowe, T. and Randau, L (2015) C/D box sRNA-guided 2'-O-methylation patterns of archaeal rRNA molecules. BMC Genomics [in press].

Plagens, A., Richter, H., Charpentier, E. and Randau L. (2015) DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes. FEMS Microbiol Rev, 39, 442-463.

Randau, L. (2015) Evolution of small guide RNA genes in hyperthermophilic archaea. Ann N Y Acad Sci, 1341, 188-193.

Publications since 2004

 
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