Contact

Dr. Hannes Link
Dr. Hannes Link
Research Group Leader
Phone: +49 6421 28 21624

Research Group Members

Dr. Peter Temitope Adeboye
Dr. Peter Temitope Adeboye
Scientific Staff Member
Phone: +49 6421 28 21486
Dominik Beuter
Dominik Beuter
Ph.D. Student
Phone: +49 6421 28 21623
Stefano Donati
Stefano Donati
Ph.D. Student
Niklas Farke
Niklas Farke
Ph.D. Student
Martin Müller
Martin Müller
Ph.D. Student
Phone: +49 6421 28 21623
Dusica Rados
Dusica Rados
Postdoctoral Fellow
Phone: +49 6421 28 21486
Timur Sander
Timur Sander
Ph.D. Student
Phone: +49 6421 28 21623
Thorben Schramm
Thorben Schramm
Ph.D. Student
Phone: +49 6421 28 21486
Chun-Ying Wang
Chun-Ying Wang
Ph.D. Student
Phone: +49 6421 28 21623

Dr. Hannes Link - Dynamic Control of Metabolic Networks

Dr. Hannes Link

Curriculum Vitae

Hannes Link (born 1979)
Diploma in Chemical Engineering, TU Munich, 2005
Ph.D., Institute of Biochemical Engineering, TU Munich, 2009
Postdoc, Institute of Molecular Systems Biology, ETH Zürich, 2010
Research group leader at the MPI in Marburg, since January 2015

Research Area: Dynamic Control of Metabolic Networks

Metabolic networks respond rapidly to internal and external perturbations by changing fluxes, metabolite concentrations and enzyme levels. Our group is interested in the regulation of these responses and their functional relevance in microbes. Therefore, we investigate known metabolic control circuits, map novel regulatory interactions and engineer synthetic metabolic regulation. The ultimate goal is to improve metabolically engineered strains by enabling self-optimization of overproduction pathways for chemicals.

Group of Hannes Link by February 2018 Zoom Image
Group of Hannes Link by February 2018

Interested in joining our team?

We are currently looking for Postdocs and PhD students to join the ERC project MapMe, especially persons with a background in computational biology or biophysics. If you are interested please contact hannes.link@synmikro.mpi-marburg.mpg.de 

Selected Publications

Donati S, Sander T, Link H (2017) Crosstalk between transcription and metabolism: how much enzyme is enough for a cell? WIREs Syst Biol Med. doi 10.1002/wsbm.1396

Guder JC , Schramm T, Sander T, Link H (2017) Time-Optimized Isotope Ratio LC-MS/MS for High-Throughput Quantification of Primary Metabolites. Analytical Chemistry 89 (3): 1624–1631.

Liu Y*, Link H*, Liu L, Du G, Chen J, Sauer U. (2016) A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis. Nature Comm. 7: 11933. *equal contr.

Link H, Fuhrer T, Gerosa L, Zamboni N, Sauer U. (2015) Real-time metabolome profiling of the metabolic switch between starvation and growth. Nature Methods 12(11):1091-1097

Link H, Christodoulou D, Sauer U. (2014) Advancing metabolic models with kinetic information. Curr Opin Biotechnol 13,29C:8-14.

Link H, Kochanowski K, Sauer U. (2013) Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo. Nature Biotechnol 31(4):357-61.

Link H, Buescher JM, Sauer U. (2012) Targeted and quantitative metabolomics in bacteria. Methods in Microbiology 39:127-150.

For a full list of publications see   Google Scholar

 
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