Contact

Prof. Dr. Regine Kahmann
Prof. Dr. Regine Kahmann
Director
Phone: +49 6421 178 501
Fax: +49 6421 178 509
Vera Matschiske-Peters
Vera Matschiske-Peters
Secretary
Phone: +49 6421 178 500
Fax: +49 6421 178 509

Research Group Members

Pierre Grognet, Ph.D.
Pierre Grognet, Ph.D.
Postdoctoral Fellow
Phone: +49 6421 178 521
Dr. Liang Liang
Dr. Liang Liang
Postdoctoral Fellow
Phone: +49 6421 178 571
Fax: +49 6421 178 599
Libera Lo Presti, Ph.D.
Libera Lo Presti, Ph.D.
Postdoctoral Fellow
Phone: +49 6421 178 530
Marino Moretti, Ph.D.
Marino Moretti, Ph.D.
Scientific staff member
Phone: +49 6421 178 521
Fax: +49 6421 178 509
Dr. Stefanie Reißmann
Dr. Stefanie Reißmann
Scientific staff member
Phone: +49 6421 178 530
Fax: +49 6421 178 599
Dr. Gabriel Schweizer
Dr. Gabriel Schweizer
Scientific staff member
Phone: +49 6421 178 511
Fax: +49 6421 178 599
Shigeyuki Tanaka, Ph.D.
Shigeyuki Tanaka, Ph.D.
Scientific staff member
Phone: +49 6421 178 511
Fax: +49 6421 178 599
Marie Tollot, Ph.D.
Marie Tollot, Ph.D.
Postdoctoral Fellow
Phone: +49 6421 178 530
Fax: +49 6421 178 599
Lay-Sun Ma, Ph.D.
Lay-Sun Ma, Ph.D.
Postdoctoral Fellow
Phone: +49 6421 178 522
Philipp Erchinger
Philipp Erchinger
Ph.D. Student
Phone: +49 6421 178 571
Xiaowei Han
Xiaowei Han
Ph.D. Student
Phone: +49 6421 178 511
Fax: +49 6421 178 599
Joachim Jungmann
Joachim Jungmann
Ph.D. Student
Phone: +49 6421 178 520
Sina Krombach
Sina Krombach
Ph.D. Student
Phone: +49 6421 178 532
Nicole Ludwig
Nicole Ludwig
Ph.D. Student
Phone: +49 6421 178 531
Fax: +49 6421 178 599
Mariana Schuster
Mariana Schuster
Ph.D. Student
Phone: +49 6421 178 532
Alexander Carsten
Alexander Carsten
Master Student
Phone: +49 6421 178 521
Friederike Hartwig
Friederike Hartwig
scientific assistant
Simon Uszkoreit
Simon Uszkoreit
Master Student
Phone: +49 6421 178 571
Christine Trippel
Christine Trippel
Master Student
Phone: +49 6421 178 511
Lena Wagenknecht
Lena Wagenknecht
Master Student
Phone: +49 6421 178 532
Fax: +49 6421 178 599
Milena Viyacheva
Guest Scientist
Phone: +49 6421 178 531
Daniela Aßmann
Daniela Aßmann
Technical Assistant
Phone: +49 6421 178 533
Fax: +49 6421 178 509
Petra Happel
Petra Happel
Technical Assistant
Phone: +49 6421 178 522
Elmar Meyer
Elmar Meyer
Technical Assistant
Phone: +49 6421 178 571
Karin Münch
Karin Münch
Technical Assistant
Nicole Rössel
Nicole Rössel
Technical Assistant
Phone: +49 6421 178 510
Volker Vincon
Volker Vincon
Technical Assistant
Phone: +49 6421 178 572
Fax: +49 6421 178 509
Stefan Schmidt
Stefan Schmidt
Gardener
Phone: +49 6421 178 638
Anita Boos
Anita Boos
Kitchen Support Service
Phone: +49 6421 178 670
Ria Faber
Ria Faber
Kitchen Support Service
Phone: +49 6421 178 670

Prof. Dr. Regine Kahmann

Prof. Dr. Regine Kahmann

Curriculum Vitae

Regine Kahmann (born 1948)
Studies in Microbiology, Universität Göttingen, 1967
Diplom (Biology), Universität Göttingen, 1972
Dr. rer. nat (Biology), Freie Universität Berlin, 1974
Postdoc and Junior Staff Member, Cold Spring Harbor Laboratory, 1980
Research Associate, Max Planck Institute for Biochemistry, Martinsried, 1982
Leader of an independent Research Group, Otto-Warburg Laboratory at the Max Planck Institute for Molecular Genetics in Berlin, 1986
Leader of an independent Research Group at the Institute for Genebiological Research in Berlin, 1992
Professor of Genetics, Institute for Genetics and Microbiology at the Ludwigs-Maximilians-Universität München, since 1992
Director and Head of the Department of Organismic Interactions at the Max Planck Institute for Terrestrial Microbiology in Marburg, since 2000
Professor of Genetics, Philipps-Universität Marburg, since 4/2001

Research Area: Molecular Phytopathology

In our group we aim for an understanding of how fungi manage to infect plants. We focus on a group of fungi that are pathogens of grasses and cereal crop plants and cause so-called smut diseases. Our prime model is the biotrophic fungus Ustilago maydis that induces tumors in infected corn plants. To establish itself in the plant tissue that needs to stay alive to support the infection, U. maydis secretes a battery of mostly completely novel effector proteins. These effectors are used to suppress plant immune responses and to reprogram the metabolism of the host to benefit fungal needs. Our goal is to determine where these effectors go after being secreted into the plant-fungus interface, what their molecular function is, how they have evolved in the arms-race between pathogen and host and how their expression is regulated.

Smut fungi

Smut fungi comprise a large group of biotrophic pathogens which parasitize mostly on grasses including a number of cereal hosts like maize, barley and wheat. They are characterized by a narrow host range, infect plants systemically and usually cause symptoms in male and female inflorescences only. The fungus Ustilago maydis, causing smut disease in maize, is an exception in that symptoms, in this case large tumors, can develop on all above ground parts of the plant. This leads to stunted growth and significant reduction in crop yield. The particular feature of U. maydis to infect all above ground parts of a maize plant, allows to conduct virulence assays in less than two weeks in maize seedlings. Combined with its highly efficient homologous recombination system that can be used to generate deletion mutants and the many molecular tools developed, the U. maydis-maize system has become one of the most attractive models for biotrophic plant pathogenic fungi and for elucidating how such pathogens cause disease.
More about "Smut fungi"

Recent publications

Tollot, M., Assmann, D., Becker, C., Altmüller, J., Dutheil, J. Y., Wegener, C.-E. and Kahmann, R. (2016). The WOPR protein Ros1 is a master regulator of sporogenesis and late effector gene expression in the maize pathogen Ustilago maydis. PLoS Pathog 12(6): e1005697. doi:10.1371/journal.ppat.1005697

Dutheil, J.Y., Mannhaupt, G., Schweizer, G., Sieber, C.M.K., Münsterkötter, M., Güldener, U., Schirawski, J., and Kahmann, R. (2016). A tale of genome compartmentalization: the evolution of virulence clusters in smut fungi. Genome Biol. Evol. 8(3): 681-701. doi: 10.1093/gbe/evw026

Schuster, M., Schweizer, G., Reissmann, S., and Kahmann, R. (2015). Genome editing in Ustilago maydis using the CRISPR-Cas system. Fungal Genetics and Biology, S1087-1845(15)30025-6. doi: 10.1016/j.fgb.2015.09.001.

Lo Presti, L., Lopez Diaz, C., Turra, D., Di Pietro, A., Hampel, M., Heimel, K., and Kahmann, R. (2015). A conserved co-chaperone is required for virulence in fungal plant pathogens. New Phytologist Oct 21. doi: 10.1111/nph.13703.

Tanaka, S., Djamei, A., Lo Presti, L., Schipper, K., Amati, S., Becker, D., Büchner, H., Kumlehn, J., Reissmann, S., and Kahmann, R. (2015). Experimental approaches to investigate effector translocation into host cells in the Ustilago maydis/maize pathosystem. Eur J Cell Biol 94, 349-358.

Tanaka, S., Han, X. and Kahmann, R. (2015) Microbial effectors target multiple steps in the salicylic acid production and signaling pathway. Front. Plant Sci. 6:349. doi: 10.3389/fpls.2015.00349

Lo Presti, L., Lanver, D., Schweizer, G., Tanaka, S., Liang, L., Tollot, M., Zuccaro, A., Reissmann, S. & Kahmann, R. (2015) Fungal Effectors and Plant Susceptibility Ann. Rev. Plant Biol. Vol. 66: 513-545 (Volume publication date April 2015) DOI: 10.1146/annurev-arplant-043014-114623.

Tanaka, S., Brefort, T., Neidig, N., Djamei, A., Kahnt, J., Vermerris, W., Koenig, S., Feussner, K., Feussner, I. & Kahmann, R. (2014) A secreted Ustilago maydis effector promotes virulence by targeting anthocyanin biosynthesis in maize. eLife 2014;3:e01355; DOI: 10.7554/eLife.01355.001.

Brefort, T., Tanaka, S., Neidig, N., Doehlemann, G., Vincon, V. & Kahmann, R. (2014) Characterization of the largest effector gene cluster of Ustilago maydis. PLoS Pathog 10(7): e1003866. doi:10.1371/journal.ppat.1003866

Lanver, D., Berndt, P., Tollot, M., Naik, V., Vranes, M., Warmann, T., Münch, K., Rössel, N. & Kahmann, R. (2014) Plant surface cues prime Ustilago maydis for biotrophic development. PLoS Pathog 10(7): e1004272. doi:10.1371/journal.ppat.1004272

Sarkari, P., Reindl, M., Stock, J., Müller, O., Kahmann, R., Feldbrügge, M., Schipper, K. (2014) Improved expression of single-chain antibodies in Ustilago maydis. J. Biotechnol. http://dx.doi.org/10.1016/j.jbiotec.2014.06.028

Perez-Nadales, E., Almeida-Nogueira, M. F., Baldin, C., Díaz, S., El Ghalid, M., Grund, E., Lengeler, K., Marchegiani, E., Mehrotra, P. V., Moretti, M., Naik, V., Oses Ruiz, M., Oskarsson, T., Schäfer, K., Wasserstrom, L., Brakhage, A., Gow, N. A. R., Kahmann, R., Lebrun, M.-H., Perez-Martin, J., Di Pietro, A., Talbot, N. J., Toquin, V., Walther, A., Wendland, J. (2014) Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genet. Biol. http://dx.doi.org/10.1016/j.fgb.2014.06.011

 
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