Robust Population control in Synthetic Communities
Graduate Students Mini-Symposium
- Date: Mar 13, 2017
- Time: 01:50 PM (Local Time Germany)
- Speaker: Anne Löchner
- MPI / Systems and Synthetic Microbiology
- Location: MPI for Terrestrial Microbiology
- Room: Lecture hall
- Host: Prof. Dr. Victor Sourjik
- Contact: victor.sourjik@synmikro.mpi-marburg.mpg.de
Using microorganisms for bioremediation and metabolic engineering becomes popular in times of declining amounts of petroleum. Even though many organisms could be successfully engineered, a high metabolic burden and a lack of evolutionary stability remain. Therefore the usage of synthetic engineered microbial communities is under investigation as a potential solution. One challenge is the control of growth of each of the populations within the community. In order to balance the growth in a mixed synthetic E. coli community, we propose two growth-balancing systems: one is a quorum sensing system, the other one is a contact dependent inhibition system.