Graduate Students Mini-Symposium

Adhesins in Candida glabrata

  • Date: Feb 27, 2017
  • Time: 13:15
  • Speaker: Bernard Lutterbach
  • UMR / Molekulare Genetik
  • Location: MPI for Terrestrial Microbiology
  • Room: Lecture hall
  • Host: Prof. Dr. Hans-Ulrich Mösch
  • Contact: hansulrich.moesch@biologie.uni-marburg.de

The yeast Candida glabrata is an opportunistic human-pathogenic fungus. Adhesion to mucosal surfaces is a critical step for colonization and invasion of the host. Therefore Candida glabrata utilizes a wide variety of sticky surface-exposed cell-wall proteins, known as adhesins. I am especially interested one subfamily of adhesins, the Pwp family. From structural data I showed that the Pwps have a PA14-domain with putative glycan binding capacity. My interests are especially ligand specificity, affinity and function of the Pwp family.

 
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