Characterization of RomX and RomY, two novel motility regulators in Myxococcus xanthus
Graduate Students Mini-Symposium
- Date: Apr 18, 2016
- Time: 04:25 PM (Local Time Germany)
- Speaker: Dobromir Szadkowski
- MPI / Dept. of Ecophysiology
- Location: MPI for Terrestrial Microbiology
- Room: Lecture hall
- Host: Prof. Dr. L. Søgaard-Andersen
- Contact: sogaard@mpi-marburg.mpg.de
The rod-shaped Myxococcus xanthus
cells move with defined leading and lagging cell poles on surfaces. Occasionally,
cells undergo reversals, which correspond to an inversion of the
leading-lagging polarity axis. Reversals depend on relocalization between the
poles of three polarly localized proteins that regulate polarity, i.e. the
Ras-like GTPase MglA, its cognate GAP MglB, and the response regulator RomR. To
understand how these three proteins localize dynamically to the cell poles, we
performed a phylogenomic analysis and identified two uncharacterized proteins,
RomX and RomY, that co-occur with RomR. Here, we report on the function of RomX
and RomY in motility.