Structural variation of type I-F CRISPR RNA guided DNA surveillance
Graduate Students Mini-Symposium
- Date: Oct 23, 2017
- Time: 01:15 PM (Local Time Germany)
- Speaker: Patrick Pausch
- LOEWE, Molecular Plasticity of Microbial Adaptation
- Location: MPI for Terrestrial Microbiology
- Room: Lecture hall
- Host: Dr. Gert Bange
- Contact: gert.bange@synmikro.uni-marburg.de
CRISPR-Cas systems are adaptive immune systems against invading nucleic acids. Interestingly, although the CRISPR-Cas machinery that extends the CRISPR array upon novel threads is highly conserved, the surveillance and effector modules diversified substantially during the course of evolution. The ongoing ‘bacteria-virus’ arms race is supposed to be the main driving force of the continuing co-evolution and structural diversification of bacterial defense and viral CRISPR evasion mechanisms. Our comparative structural analysis of the type I-F variant (I-Fv) CRISPR Cascade complex with the evolutionary closely related type I-F Cascade sheds light on the astonishingly high modularity of CRISPR-Cas systems that might have emerged in response to the ‘bacteria-virus’ arms race.