Microbiology Seminar Series

Cell-wall remodelling drives engulfment during sporulation in Bacillus subtilis

  • Date: Sep 25, 2017
  • Time: 13:15
  • Speaker: Dr. Robert Endres
  • Imperial College London, Faculty of Natural Sciences, Department of Life Sciences
  • Location: MPI for Terrestrial Microbiology
  • Room: Lecture hall
  • Host: Prof. Dr. Victor Sourjik
  • Contact: victor.sourjik@synmikro.mpi-marburg.mpg.de

To survive starvation, Bacillus subtilis forms durable spores. After asymmetric cell division, the septum grows around the forespore in a process called engulfment, but the mechanism of force generation is unknown. In this talk, I will report on our recent progress in understanding the engulfment process, using an integrative approach of time-lapse microscopy from the Pogliano lab at UC San Diego, image analysis, and molecular as well as physics-driven modelling from my group at Imperial College London. I will show that relatively simple principles of cell-wall remodelling can explain the observed dynamics of engulfment in wild-type and drug-treated cells.


 
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