Lennart Randau

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Research group members
Group Leader: Dr. Lennart Randau Postdoctoral associate: Dr. André Plagens
PhD students: Srivatsa Dwarakanath, Hagen Richter, Andreas Su, Judith Zöphel
Diploma/Master students: Sabine Mohr, Vanessa Tripp
BSc students: Patrick Pausch, Kristina Rau
Technical assistant: Jeanette Schermuly

Dr. Lennart Randau

Curriculum Vitae

Lennart Randau (born 1978)
Diplom (Biology), TU Braunschweig, Germany, 2002
Ph.D. (Dr. rer. nat.), TU Braunschweig, Germany, 2006
Post-doc, Yale University, USA, 2006 - 2010)
Head of the Max Planck Research Group "Prokaryotic Small RNA Biology" at the MPI for Terrestrial Microbiology, Marburg, since 12/2010

Research area: Prokaryotic Small RNA Biology

Our research is aimed at understanding the processing of small RNAs involved in the defense against integrative elements (e.g. viruses) in Bacteria and Archaea. First, we investigate the RNAs that play the central role in the prokaryotic CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) immune system. Second, we study the evolution of diverse disruptive elements within archaeal transfer RNA (tRNA) genes. These systems will be exploited for the modulation of prokaryotic immunity and the creation of gene knock-down technology. Our research uses an interdisciplinary approach combining computational, biochemical and microbiological techniques.
More about "Prokaryotic Small RNA Biology"
MPI homepage   Our own homepage

Recent publications

Su, A.A.H., Randau, L. (2011) A-to-I and C-to-U editing within transfer RNAs. Biochemistry (Moscow), 76, 932-937

Yuan, J., Gogakos, T., Babina, A.M., Söll D. and Randau, L. (2011) Change of tRNA identity leads to a divergent orthogonal histidyl-tRNA synthetase/tRNAHis pair. Nucleic Acids Res, 39, 2286-2293

Heinemann, I.U., Söll, D. and Randau, L. (2010) Transfer RNA processing in archaea: Unusual pathways and enzymes. FEBS Lett, 584, 303-309

Randau, L., Stanley, B.J., Kohlway, A., Mechta, S., Xiong, Y. and Söll, D. (2009) A cytidine deaminase edits C-to-U in transfer RNAs in archaea. Science, 324, 657-659

Randau, L., Schröder, I and Söll, D. (2008) Life without RNase P. Nature, 453, 120-123

Publications since 2004